JPS5695173A - Preparation of 5-fluorocytosine - Google Patents
Preparation of 5-fluorocytosineInfo
- Publication number
- JPS5695173A JPS5695173A JP17159779A JP17159779A JPS5695173A JP S5695173 A JPS5695173 A JP S5695173A JP 17159779 A JP17159779 A JP 17159779A JP 17159779 A JP17159779 A JP 17159779A JP S5695173 A JPS5695173 A JP S5695173A
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen fluoride
- cytosine
- fluorine
- reaction
- amino group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 title 1
- 229960004413 flucytosine Drugs 0.000 title 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 6
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 4
- 229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229940104302 cytosine Drugs 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 241000222122 Candida albicans Species 0.000 abstract 1
- 206010007134 Candida infections Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 201000003984 candidiasis Diseases 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000009615 deamination Effects 0.000 abstract 1
- 238000006481 deamination reaction Methods 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17159779A JPS5695173A (en) | 1979-12-28 | 1979-12-28 | Preparation of 5-fluorocytosine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17159779A JPS5695173A (en) | 1979-12-28 | 1979-12-28 | Preparation of 5-fluorocytosine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5695173A true JPS5695173A (en) | 1981-08-01 |
| JPS6252749B2 JPS6252749B2 (enrdf_load_stackoverflow) | 1987-11-06 |
Family
ID=15926108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17159779A Granted JPS5695173A (en) | 1979-12-28 | 1979-12-28 | Preparation of 5-fluorocytosine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5695173A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106554115A (zh) * | 2016-12-08 | 2017-04-05 | 西安润格环保科技有限公司 | 一种煤化工废水逐级减压脱酸脱氨方法和系统 |
| CN110615767A (zh) * | 2019-10-26 | 2019-12-27 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| CN110746360A (zh) * | 2019-10-26 | 2020-02-04 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| US10995075B2 (en) | 2014-08-29 | 2021-05-04 | University Of Durham | Process for producing fluorocytosine and fluorocytosine derivatives |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01305259A (ja) * | 1988-06-03 | 1989-12-08 | Matsushita Electric Ind Co Ltd | 給湯機 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4976882A (enrdf_load_stackoverflow) * | 1972-11-28 | 1974-07-24 |
-
1979
- 1979-12-28 JP JP17159779A patent/JPS5695173A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4976882A (enrdf_load_stackoverflow) * | 1972-11-28 | 1974-07-24 |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10995075B2 (en) | 2014-08-29 | 2021-05-04 | University Of Durham | Process for producing fluorocytosine and fluorocytosine derivatives |
| CN106554115A (zh) * | 2016-12-08 | 2017-04-05 | 西安润格环保科技有限公司 | 一种煤化工废水逐级减压脱酸脱氨方法和系统 |
| CN110615767A (zh) * | 2019-10-26 | 2019-12-27 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| CN110746360A (zh) * | 2019-10-26 | 2020-02-04 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| CN110746360B (zh) * | 2019-10-26 | 2022-06-28 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| CN110615767B (zh) * | 2019-10-26 | 2022-06-28 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6252749B2 (enrdf_load_stackoverflow) | 1987-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |