JPS5687598A - Manufacture of antitumoral antibiotic and intermediate therefor - Google Patents

Manufacture of antitumoral antibiotic and intermediate therefor

Info

Publication number
JPS5687598A
JPS5687598A JP16147580A JP16147580A JPS5687598A JP S5687598 A JPS5687598 A JP S5687598A JP 16147580 A JP16147580 A JP 16147580A JP 16147580 A JP16147580 A JP 16147580A JP S5687598 A JPS5687598 A JP S5687598A
Authority
JP
Japan
Prior art keywords
antitumoral
antibiotic
manufacture
intermediate therefor
therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16147580A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6328078B2 (US08088918-20120103-C00476.png
Inventor
Suarato Antoniino
Penko Serujio
Arukamone Fuederiko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlo Erba SpA filed Critical Carlo Erba SpA
Publication of JPS5687598A publication Critical patent/JPS5687598A/ja
Publication of JPS6328078B2 publication Critical patent/JPS6328078B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP16147580A 1979-11-22 1980-11-18 Manufacture of antitumoral antibiotic and intermediate therefor Granted JPS5687598A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7940457 1979-11-22

Publications (2)

Publication Number Publication Date
JPS5687598A true JPS5687598A (en) 1981-07-16
JPS6328078B2 JPS6328078B2 (US08088918-20120103-C00476.png) 1988-06-07

Family

ID=10509359

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16147580A Granted JPS5687598A (en) 1979-11-22 1980-11-18 Manufacture of antitumoral antibiotic and intermediate therefor

Country Status (12)

Country Link
US (1) US4345068A (US08088918-20120103-C00476.png)
EP (1) EP0030295B1 (US08088918-20120103-C00476.png)
JP (1) JPS5687598A (US08088918-20120103-C00476.png)
AT (1) AT369385B (US08088918-20120103-C00476.png)
CA (1) CA1169421A (US08088918-20120103-C00476.png)
DE (1) DE3063541D1 (US08088918-20120103-C00476.png)
DK (2) DK163517C (US08088918-20120103-C00476.png)
IL (1) IL61508A (US08088918-20120103-C00476.png)
IT (1) IT1163001B (US08088918-20120103-C00476.png)
SU (1) SU1181549A3 (US08088918-20120103-C00476.png)
UA (1) UA6016A1 (US08088918-20120103-C00476.png)
YU (1) YU296580A (US08088918-20120103-C00476.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016159092A1 (ja) * 2015-03-30 2016-10-06 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 エピルビシンの製造方法およびその新規な製造中間体

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3200809C2 (de) * 1981-01-21 1986-08-28 Farmitalia Carlo Erba S.p.A., Mailand/Milano 4'-Desoxy-3'-epi-daunorubicin und -doxorubicin, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
GB8414619D0 (en) * 1984-06-08 1984-07-11 Erba Farmitalia Anthracyclines
DE3500029A1 (de) * 1985-01-02 1986-09-04 Farmitalia Carlo Erba S.p.A., Mailand/Milano Anthracyclinester
IT1196503B (it) * 1986-07-16 1988-11-16 Erba Farmitalia Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
GB2196626B (en) * 1986-10-15 1990-09-19 Erba Farmitalia Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
CA2587470A1 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusale M Combination therapy associating preferably a ceramide with a cytotoxic drug
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2006111561A1 (en) * 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins
DE06848583T1 (de) * 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
PL2301943T3 (pl) 2009-09-08 2014-06-30 Heraeus Precious Metals Gmbh Krystalizacja epidaunorubicyny x HCI
KR101125460B1 (ko) * 2010-03-24 2012-03-28 동아제약주식회사 에피루비신 염산염의 신규한 결정형
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103204888B (zh) * 2012-01-15 2016-08-17 山东新时代药业有限公司 一种盐酸表柔比星中间体的制备方法
WO2015000132A1 (zh) 2013-07-02 2015-01-08 浙江海正药业股份有限公司 表阿霉素的制备方法及其中间体
CN103694291B (zh) * 2013-12-24 2015-06-17 深圳万乐药业有限公司 一种戊柔比星的合成方法
DE102014208194A1 (de) 2014-04-30 2015-11-05 Heraeus Deutschland GmbH & Co. KG Aufreinigung von Epidaunorubicin
CN104098627B (zh) * 2014-07-31 2017-04-12 大连大学 一类n‑三氟乙酰表柔红霉素的硒代衍生物，其制备方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1457632A (en) * 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1502121A (en) * 1975-08-02 1978-02-22 Farmaceutici Italia Anthracyclines

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016159092A1 (ja) * 2015-03-30 2016-10-06 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 エピルビシンの製造方法およびその新規な製造中間体
JPWO2016159092A1 (ja) * 2015-03-30 2018-01-25 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 エピルビシンの製造方法およびその新規な製造中間体
CN107683284A (zh) * 2015-03-30 2018-02-09 明治制果药业株式会社 表柔比星的制造方法及其新的制造中间体
US10301343B2 (en) 2015-03-30 2019-05-28 Meiji Seika Pharma Co., Ltd. Method of producing epirubicin and novel production intermediate thereof

Also Published As

Publication number Publication date
DK163517B (da) 1992-03-09
DK254490D0 (da) 1990-10-22
IL61508A0 (en) 1980-12-31
IT8026127A0 (it) 1980-11-20
DK163246B (da) 1992-02-10
CA1169421A (en) 1984-06-19
EP0030295A1 (de) 1981-06-17
IL61508A (en) 1983-12-30
DE3063541D1 (en) 1983-07-07
AT369385B (de) 1982-12-27
ATA564080A (de) 1982-05-15
EP0030295B1 (de) 1983-05-25
SU1181549A3 (ru) 1985-09-23
IT1163001B (it) 1987-04-08
DK163517C (da) 1992-08-31
YU296580A (en) 1983-02-28
JPS6328078B2 (US08088918-20120103-C00476.png) 1988-06-07
UA6016A1 (uk) 1994-12-29
DK254490A (da) 1990-10-22
DK163246C (da) 1992-06-29
DK498080A (da) 1981-05-23
US4345068A (en) 1982-08-17

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