JPS5686130A - Alpha-halo m-benzoylphenyl acetic acid derivative - Google Patents
Alpha-halo m-benzoylphenyl acetic acid derivativeInfo
- Publication number
- JPS5686130A JPS5686130A JP16352779A JP16352779A JPS5686130A JP S5686130 A JPS5686130 A JP S5686130A JP 16352779 A JP16352779 A JP 16352779A JP 16352779 A JP16352779 A JP 16352779A JP S5686130 A JPS5686130 A JP S5686130A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- benzoylphenyl
- acetic acid
- compound
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:α-Halo(m-benzoylphenyl)acetic acid derivatives of formula I (X is Cl, Br, I; R is H, lower alkyl).
EXAMPLE: α-Bromo(m-benzoylphenyl)acetic acid derivative.
USE: An intermediate that can advantageously led to α-(m-benzoylphenyl)propionic acid (Ketoprofen), which is used as an anti-inflammatory and analgesic.
PREPARATION: The radical halogenation of a compound of formula V is effected using a halogenating agent such as N-bromosuccimide in the presence of a radical initiator such as benzoyl peroxide to produce the compound of formula I in high yield. Further, the product is thionated, when necessary, esterified to give a compound of formula II. The product is methylated, the resultant compound of formula III is desulfurized by reduction and, when necessary, hydrolyzed to give ketoprofen of formula IV readily in high yield.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16352779A JPS5686130A (en) | 1979-12-18 | 1979-12-18 | Alpha-halo m-benzoylphenyl acetic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16352779A JPS5686130A (en) | 1979-12-18 | 1979-12-18 | Alpha-halo m-benzoylphenyl acetic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5686130A true JPS5686130A (en) | 1981-07-13 |
Family
ID=15775558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16352779A Pending JPS5686130A (en) | 1979-12-18 | 1979-12-18 | Alpha-halo m-benzoylphenyl acetic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5686130A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06263635A (en) * | 1990-09-28 | 1994-09-20 | Iflo Sas Di Giorgio & Aldo Laguzzi | Contraceptive and menstrual cycle regulatory medicine having antineoplastic properties, its use, and its preparation |
-
1979
- 1979-12-18 JP JP16352779A patent/JPS5686130A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06263635A (en) * | 1990-09-28 | 1994-09-20 | Iflo Sas Di Giorgio & Aldo Laguzzi | Contraceptive and menstrual cycle regulatory medicine having antineoplastic properties, its use, and its preparation |
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