JPS5686130A - Alpha-halo m-benzoylphenyl acetic acid derivative - Google Patents

Alpha-halo m-benzoylphenyl acetic acid derivative

Info

Publication number
JPS5686130A
JPS5686130A JP16352779A JP16352779A JPS5686130A JP S5686130 A JPS5686130 A JP S5686130A JP 16352779 A JP16352779 A JP 16352779A JP 16352779 A JP16352779 A JP 16352779A JP S5686130 A JPS5686130 A JP S5686130A
Authority
JP
Japan
Prior art keywords
formula
benzoylphenyl
acetic acid
compound
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16352779A
Other languages
Japanese (ja)
Inventor
Kazutaka Arai
Yasuo Takakuwa
Isao Hashiba
Tadashi Nishikimi
Genichi Dobashi
Katsuyuki Ogura
Shuichi Mitamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP16352779A priority Critical patent/JPS5686130A/en
Publication of JPS5686130A publication Critical patent/JPS5686130A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:α-Halo(m-benzoylphenyl)acetic acid derivatives of formula I (X is Cl, Br, I; R is H, lower alkyl).
EXAMPLE: α-Bromo(m-benzoylphenyl)acetic acid derivative.
USE: An intermediate that can advantageously led to α-(m-benzoylphenyl)propionic acid (Ketoprofen), which is used as an anti-inflammatory and analgesic.
PREPARATION: The radical halogenation of a compound of formula V is effected using a halogenating agent such as N-bromosuccimide in the presence of a radical initiator such as benzoyl peroxide to produce the compound of formula I in high yield. Further, the product is thionated, when necessary, esterified to give a compound of formula II. The product is methylated, the resultant compound of formula III is desulfurized by reduction and, when necessary, hydrolyzed to give ketoprofen of formula IV readily in high yield.
COPYRIGHT: (C)1981,JPO&Japio
JP16352779A 1979-12-18 1979-12-18 Alpha-halo m-benzoylphenyl acetic acid derivative Pending JPS5686130A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16352779A JPS5686130A (en) 1979-12-18 1979-12-18 Alpha-halo m-benzoylphenyl acetic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16352779A JPS5686130A (en) 1979-12-18 1979-12-18 Alpha-halo m-benzoylphenyl acetic acid derivative

Publications (1)

Publication Number Publication Date
JPS5686130A true JPS5686130A (en) 1981-07-13

Family

ID=15775558

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16352779A Pending JPS5686130A (en) 1979-12-18 1979-12-18 Alpha-halo m-benzoylphenyl acetic acid derivative

Country Status (1)

Country Link
JP (1) JPS5686130A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06263635A (en) * 1990-09-28 1994-09-20 Iflo Sas Di Giorgio & Aldo Laguzzi Contraceptive and menstrual cycle regulatory medicine having antineoplastic properties, its use, and its preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06263635A (en) * 1990-09-28 1994-09-20 Iflo Sas Di Giorgio & Aldo Laguzzi Contraceptive and menstrual cycle regulatory medicine having antineoplastic properties, its use, and its preparation

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