JPS5681581A - Preparation of antispasmodic agent - Google Patents
Preparation of antispasmodic agentInfo
- Publication number
- JPS5681581A JPS5681581A JP15813279A JP15813279A JPS5681581A JP S5681581 A JPS5681581 A JP S5681581A JP 15813279 A JP15813279 A JP 15813279A JP 15813279 A JP15813279 A JP 15813279A JP S5681581 A JPS5681581 A JP S5681581A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reacted
- piperidine
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled substance having an antiacetylcholinergic action readily, by reacting a 2-cychlohexyl-γ-2-phenyl-t-4-halogenomethyl-1,3-dioxolane as an intermediate with piperidine.
CONSTITUTION: A compound of formula I (X is halogen) is reacted with piperidine to give a compound of formula II, which is then reacted with a methyl halide to form a quaternary ammonium salt or the compound of formula I is reacted with N- methylpiperidine to afford the compound of formula III. The compound of formula I is obtained by reacting a compound of formula IV with an inorganic halide in high yield, and the isomer cannot be easily separated by the conventional method. The compound of formula III which is a pure trans isomer can be obtained from the compound of formula I and is useful for preparing the trans isomer of the compound of formula V useful as a ganglion blocking agent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15813279A JPS5681581A (en) | 1979-12-07 | 1979-12-07 | Preparation of antispasmodic agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15813279A JPS5681581A (en) | 1979-12-07 | 1979-12-07 | Preparation of antispasmodic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5681581A true JPS5681581A (en) | 1981-07-03 |
| JPS638945B2 JPS638945B2 (en) | 1988-02-25 |
Family
ID=15664971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15813279A Granted JPS5681581A (en) | 1979-12-07 | 1979-12-07 | Preparation of antispasmodic agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5681581A (en) |
-
1979
- 1979-12-07 JP JP15813279A patent/JPS5681581A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS638945B2 (en) | 1988-02-25 |
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