JPS5668644A - Preparation of gamma-chloro-beta-hydroxybutyric acid alkyl ester - Google Patents

Preparation of gamma-chloro-beta-hydroxybutyric acid alkyl ester

Info

Publication number
JPS5668644A
JPS5668644A JP14410479A JP14410479A JPS5668644A JP S5668644 A JPS5668644 A JP S5668644A JP 14410479 A JP14410479 A JP 14410479A JP 14410479 A JP14410479 A JP 14410479A JP S5668644 A JPS5668644 A JP S5668644A
Authority
JP
Japan
Prior art keywords
preparation
reaction
epichlorohydrin
chloro
gamma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14410479A
Other languages
Japanese (ja)
Other versions
JPS6017776B2 (en
Inventor
Iwao Kobayashi
Tsunehiko Shimizui
Yoshio Osai
Kyoji Aoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denka Co Ltd
Original Assignee
Denki Kagaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denki Kagaku Kogyo KK filed Critical Denki Kagaku Kogyo KK
Priority to JP54144104A priority Critical patent/JPS6017776B2/en
Publication of JPS5668644A publication Critical patent/JPS5668644A/en
Publication of JPS6017776B2 publication Critical patent/JPS6017776B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as a raw material for the preparation of an antiepileptic agent, in high yield, by reacting epichlorohydrin with Co and an aliphatic alcohol in the presence of cobalt carbonyl catalyst and a specific base.
CONSTITUTION: In the preparation of the titled compound by the reaction of epichlorohydrin with CO and an aliphatic alcohol in the presence of a cobalt carbonyl catalyst (e.g. di-cobalt octacarbonyl), the reaction is carried out in the presence of an alkali metal compound or an alkaline earth metal compound. The amount of base is 0.01W1, pref. 0.03W0.1mol/mol of epichlorohydrin. The catalytic activity is maintained at a high level, and the reaction is carried out in high selectivity by keeping the pH of the reaction system above 7.
COPYRIGHT: (C)1981,JPO&Japio
JP54144104A 1979-11-07 1979-11-07 Production method of γ-chloro-β-hydroxybutyric acid alkyl ester Expired JPS6017776B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP54144104A JPS6017776B2 (en) 1979-11-07 1979-11-07 Production method of γ-chloro-β-hydroxybutyric acid alkyl ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54144104A JPS6017776B2 (en) 1979-11-07 1979-11-07 Production method of γ-chloro-β-hydroxybutyric acid alkyl ester

Publications (2)

Publication Number Publication Date
JPS5668644A true JPS5668644A (en) 1981-06-09
JPS6017776B2 JPS6017776B2 (en) 1985-05-07

Family

ID=15354269

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54144104A Expired JPS6017776B2 (en) 1979-11-07 1979-11-07 Production method of γ-chloro-β-hydroxybutyric acid alkyl ester

Country Status (1)

Country Link
JP (1) JPS6017776B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57202042U (en) * 1981-06-19 1982-12-22
JPS59118093A (en) * 1982-12-06 1984-07-07 シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア Production of l-carnitine and chemical intermediate used therein
EP0223328A1 (en) 1985-07-26 1987-05-27 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing oxiracetam
JPH04124157A (en) * 1990-09-12 1992-04-24 Daiso Co Ltd Production of optically active 4-chloro-3-hydroxybutanoic acid and its ester
JPH0767674A (en) * 1982-12-06 1995-03-14 Sigma Tau Ind Farmaceut Riunite Spa Optically active gamma - substituted beta - hydroxybutyric acid derivative
JP2010095256A (en) * 2008-10-14 2010-04-30 Yasuhiro Yamato Squeeze-out container with base lid

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0517095Y2 (en) * 1987-04-03 1993-05-07

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57202042U (en) * 1981-06-19 1982-12-22
JPS6124748Y2 (en) * 1981-06-19 1986-07-25
JPS59118093A (en) * 1982-12-06 1984-07-07 シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア Production of l-carnitine and chemical intermediate used therein
JPH0767674A (en) * 1982-12-06 1995-03-14 Sigma Tau Ind Farmaceut Riunite Spa Optically active gamma - substituted beta - hydroxybutyric acid derivative
EP0223328A1 (en) 1985-07-26 1987-05-27 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing oxiracetam
US4686296A (en) * 1985-07-26 1987-08-11 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing oxiracetam
JPH04124157A (en) * 1990-09-12 1992-04-24 Daiso Co Ltd Production of optically active 4-chloro-3-hydroxybutanoic acid and its ester
JP2010095256A (en) * 2008-10-14 2010-04-30 Yasuhiro Yamato Squeeze-out container with base lid

Also Published As

Publication number Publication date
JPS6017776B2 (en) 1985-05-07

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