JPS5651452A

JPS5651452A - Derivative of acylated indole, its preparation and blood platelet coagulation suppressing agent containing said compound as effective component

Derivative of acylated indole, its preparation and blood platelet coagulation suppressing agent containing said compound as effective component

Info

Publication number: JPS5651452A
Authority: JP; Japan
Prior art keywords: compound; formula; derivative; preparation; indole
Prior art date: 1979-10-03
Legal status : Granted

Application number

JP12672579A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6241499B2 (enrdf_load_stackoverflow

Inventor

Takeo Oba

Toshio Tanaka

Noriaki Okamura

Kenzo Watanabe

Kiyoshi Sakauchi

Akira Otsu

Tatsuyuki Naritomo

Seiji Kurozumi

Takeshi Yu

Current Assignee

Teijin Ltd

Original Assignee

Teijin Ltd

Priority date

1979-10-03

Filing date

1979-10-03

Publication date

1981-05-09

1979-10-03 Application filed by Teijin Ltd filed Critical Teijin Ltd

1979-10-03 Priority to JP12672579A priority Critical patent/JPS5651452A/ja

1980-06-27 Priority to EP19800302180 priority patent/EP0022634B1/en

1980-06-27 Priority to DE8080302180T priority patent/DE3062613D1/de

1981-05-09 Publication of JPS5651452A publication Critical patent/JPS5651452A/ja

1987-09-03 Publication of JPS6241499B2 publication Critical patent/JPS6241499B2/ja

Status Granted legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title abstract 3
210000001772 blood platelet Anatomy 0.000 title abstract 2
230000015271 coagulation Effects 0.000 title abstract 2
238000005345 coagulation Methods 0.000 title abstract 2
150000002475 indoles Chemical class 0.000 title abstract 2
-1 (substituted) phenyl Chemical group 0.000 abstract 3
239000003795 chemical substances by application Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
230000003449 preventive effect Effects 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
XYLYYSLTPSMHJR-UHFFFAOYSA-N 3-(3-benzoyl-2-methylindol-1-yl)butan-2-one Chemical compound C12=CC=CC=C2N(C(C(C)=O)C)C(C)=C1C(=O)C1=CC=CC=C1 XYLYYSLTPSMHJR-UHFFFAOYSA-N 0.000 abstract 1
206010061216 Infarction Diseases 0.000 abstract 1
125000002723 alicyclic group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000007514 bases Chemical class 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003527 fibrinolytic agent Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000007574 infarction Effects 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000002980 postoperative effect Effects 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical class FC(F)(F)* 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1