JPS574971A - Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent - Google Patents

Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent

Info

Publication number
JPS574971A
JPS574971A JP7830580A JP7830580A JPS574971A JP S574971 A JPS574971 A JP S574971A JP 7830580 A JP7830580 A JP 7830580A JP 7830580 A JP7830580 A JP 7830580A JP S574971 A JPS574971 A JP S574971A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
phenyl
compound
indole derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7830580A
Other languages
Japanese (ja)
Inventor
Takeo Oba
Takeshi Yu
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Seiji Kurozumi
Akira Otsu
Tatsuyuki Naritomo
Yoshiki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP7830580A priority Critical patent/JPS574971A/en
Publication of JPS574971A publication Critical patent/JPS574971A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:An acylated indole derivative expressed by formula I (R1 is H or lower alkyl: R2 is lower alkyl; R3 is H, OH, halogen, etc.; Z is phenyl or phenyl substituted by R3; Y is S, SO or SO2; A is H, lower alkyl, phenyl, phenylalkyl or 5- or 6-membered heterocyclic ring containing O, S or N, etc,; n is an integer 1W 10; however, A is not H when Y is SO or SO2). an optically active substance or a salt thereof.
EXAMPLE: 3-Benzoyl-1-(1-ethylthio-2-propyl)-2-methylindole.
USE: A preventing agent for cardiovascular infarction and postoperative thrombosis or a preventing agent or remedy for arteriosclerosis exhibiting improved ability to inhibit the blood platelet aggregation with low ulcerating ability in the stomach and intestines.
PROCESS: A compound of formula II is condensed with a compound of the formula A1-S-S-A1 (A1 is lower alkyl, phenyl, etc.) to give the compound of formula I in which A is A1.
COPYRIGHT: (C)1982,JPO&Japio
JP7830580A 1980-06-12 1980-06-12 Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent Pending JPS574971A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7830580A JPS574971A (en) 1980-06-12 1980-06-12 Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7830580A JPS574971A (en) 1980-06-12 1980-06-12 Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent

Publications (1)

Publication Number Publication Date
JPS574971A true JPS574971A (en) 1982-01-11

Family

ID=13658209

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7830580A Pending JPS574971A (en) 1980-06-12 1980-06-12 Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent

Country Status (1)

Country Link
JP (1) JPS574971A (en)

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