JPS574971A - Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent - Google Patents
Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituentInfo
- Publication number
- JPS574971A JPS574971A JP7830580A JP7830580A JPS574971A JP S574971 A JPS574971 A JP S574971A JP 7830580 A JP7830580 A JP 7830580A JP 7830580 A JP7830580 A JP 7830580A JP S574971 A JPS574971 A JP S574971A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lower alkyl
- phenyl
- compound
- indole derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:An acylated indole derivative expressed by formula I (R1 is H or lower alkyl: R2 is lower alkyl; R3 is H, OH, halogen, etc.; Z is phenyl or phenyl substituted by R3; Y is S, SO or SO2; A is H, lower alkyl, phenyl, phenylalkyl or 5- or 6-membered heterocyclic ring containing O, S or N, etc,; n is an integer 1W 10; however, A is not H when Y is SO or SO2). an optically active substance or a salt thereof.
EXAMPLE: 3-Benzoyl-1-(1-ethylthio-2-propyl)-2-methylindole.
USE: A preventing agent for cardiovascular infarction and postoperative thrombosis or a preventing agent or remedy for arteriosclerosis exhibiting improved ability to inhibit the blood platelet aggregation with low ulcerating ability in the stomach and intestines.
PROCESS: A compound of formula II is condensed with a compound of the formula A1-S-S-A1 (A1 is lower alkyl, phenyl, etc.) to give the compound of formula I in which A is A1.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7830580A JPS574971A (en) | 1980-06-12 | 1980-06-12 | Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7830580A JPS574971A (en) | 1980-06-12 | 1980-06-12 | Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS574971A true JPS574971A (en) | 1982-01-11 |
Family
ID=13658209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7830580A Pending JPS574971A (en) | 1980-06-12 | 1980-06-12 | Acylated indole derivative, its preparation and pharmaceutical composition containing the same as active constituent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS574971A (en) |
-
1980
- 1980-06-12 JP JP7830580A patent/JPS574971A/en active Pending
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