JPS5649341A - Anthracyclinone and its preparation - Google Patents

Anthracyclinone and its preparation

Info

Publication number
JPS5649341A
JPS5649341A JP11552079A JP11552079A JPS5649341A JP S5649341 A JPS5649341 A JP S5649341A JP 11552079 A JP11552079 A JP 11552079A JP 11552079 A JP11552079 A JP 11552079A JP S5649341 A JPS5649341 A JP S5649341A
Authority
JP
Japan
Prior art keywords
compound
formula
anthracyclinone
actinomyces
ferm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11552079A
Other languages
Japanese (ja)
Other versions
JPS627905B2 (en
Inventor
Shunichi Oki
Akihiro Yoshimoto
Kageaki Kono
Taiji Inui
Tomio Takeuchi
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Inc
Sanraku Ocean Co Ltd
Original Assignee
Sanraku Inc
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanraku Inc, Sanraku Ocean Co Ltd filed Critical Sanraku Inc
Priority to JP11552079A priority Critical patent/JPS5649341A/en
Priority to DE8080105306T priority patent/DE3071391D1/en
Priority to EP80105306A priority patent/EP0030255B1/en
Priority to CA000359645A priority patent/CA1156577A/en
Priority to US06/184,518 priority patent/US4386198A/en
Publication of JPS5649341A publication Critical patent/JPS5649341A/en
Publication of JPS627905B2 publication Critical patent/JPS627905B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: A specific actinomyces is cultured to produce directly an acravinone which is used as an intermediate of adriamycin, a chemotherapeutic agent against cancers.
CONSTITUTION: A mutant (FERM-5081 or 5082) originated from Streptomyces galilaeus MA144-M1 (FERM-2455) is aeorbically cultured in a usual medium for actinomyces at 20W40°C to produce an anthracyclinone of the formula (R is H, hydroxyl). The compound is novel, when R is hydroxyl. The compound of the formula corresponds to the agricon of adriamycin or daunomycin, which are widely used as a chemotherapeutic agent against cancers, and the side effects caused by these chemothrapeutic agent are reduced and the carcinostatic activity is increased by binding the compound of the formula.
COPYRIGHT: (C)1981,JPO&Japio
JP11552079A 1979-09-07 1979-09-07 Anthracyclinone and its preparation Granted JPS5649341A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP11552079A JPS5649341A (en) 1979-09-07 1979-09-07 Anthracyclinone and its preparation
DE8080105306T DE3071391D1 (en) 1979-09-07 1980-09-04 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same
EP80105306A EP0030255B1 (en) 1979-09-07 1980-09-04 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same
CA000359645A CA1156577A (en) 1979-09-07 1980-09-05 Process for preparing 2-hydroxyaklavinone and 2-hydroxyaclacinomycin-a
US06/184,518 US4386198A (en) 1979-09-07 1980-09-05 2-Hydroxyaclacinomycin A and 2-hydroxyaklavinone and process for preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11552079A JPS5649341A (en) 1979-09-07 1979-09-07 Anthracyclinone and its preparation

Publications (2)

Publication Number Publication Date
JPS5649341A true JPS5649341A (en) 1981-05-02
JPS627905B2 JPS627905B2 (en) 1987-02-19

Family

ID=14664550

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11552079A Granted JPS5649341A (en) 1979-09-07 1979-09-07 Anthracyclinone and its preparation

Country Status (1)

Country Link
JP (1) JPS5649341A (en)

Also Published As

Publication number Publication date
JPS627905B2 (en) 1987-02-19

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