JPS5649341A - Anthracyclinone and its preparation - Google Patents
Anthracyclinone and its preparationInfo
- Publication number
- JPS5649341A JPS5649341A JP11552079A JP11552079A JPS5649341A JP S5649341 A JPS5649341 A JP S5649341A JP 11552079 A JP11552079 A JP 11552079A JP 11552079 A JP11552079 A JP 11552079A JP S5649341 A JPS5649341 A JP S5649341A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- anthracyclinone
- actinomyces
- ferm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: A specific actinomyces is cultured to produce directly an acravinone which is used as an intermediate of adriamycin, a chemotherapeutic agent against cancers.
CONSTITUTION: A mutant (FERM-5081 or 5082) originated from Streptomyces galilaeus MA144-M1 (FERM-2455) is aeorbically cultured in a usual medium for actinomyces at 20W40°C to produce an anthracyclinone of the formula (R is H, hydroxyl). The compound is novel, when R is hydroxyl. The compound of the formula corresponds to the agricon of adriamycin or daunomycin, which are widely used as a chemotherapeutic agent against cancers, and the side effects caused by these chemothrapeutic agent are reduced and the carcinostatic activity is increased by binding the compound of the formula.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11552079A JPS5649341A (en) | 1979-09-07 | 1979-09-07 | Anthracyclinone and its preparation |
DE8080105306T DE3071391D1 (en) | 1979-09-07 | 1980-09-04 | 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same |
EP80105306A EP0030255B1 (en) | 1979-09-07 | 1980-09-04 | 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same |
CA000359645A CA1156577A (en) | 1979-09-07 | 1980-09-05 | Process for preparing 2-hydroxyaklavinone and 2-hydroxyaclacinomycin-a |
US06/184,518 US4386198A (en) | 1979-09-07 | 1980-09-05 | 2-Hydroxyaclacinomycin A and 2-hydroxyaklavinone and process for preparing same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11552079A JPS5649341A (en) | 1979-09-07 | 1979-09-07 | Anthracyclinone and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5649341A true JPS5649341A (en) | 1981-05-02 |
JPS627905B2 JPS627905B2 (en) | 1987-02-19 |
Family
ID=14664550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11552079A Granted JPS5649341A (en) | 1979-09-07 | 1979-09-07 | Anthracyclinone and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5649341A (en) |
-
1979
- 1979-09-07 JP JP11552079A patent/JPS5649341A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS627905B2 (en) | 1987-02-19 |
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