JPS5646812A - Central nervous system depressant - Google Patents
Central nervous system depressantInfo
- Publication number
- JPS5646812A JPS5646812A JP12487879A JP12487879A JPS5646812A JP S5646812 A JPS5646812 A JP S5646812A JP 12487879 A JP12487879 A JP 12487879A JP 12487879 A JP12487879 A JP 12487879A JP S5646812 A JPS5646812 A JP S5646812A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- nervous system
- central nervous
- depressant
- carbostyrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003874 central nervous system depressant Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 2
- QBLRMOJWUWFFOU-UHFFFAOYSA-N 6-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]-3,4-dihydro-1h-quinolin-2-one Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCC(O)CN(CC1)CCN1C1=CC=CC=C1 QBLRMOJWUWFFOU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 230000000049 anti-anxiety effect Effects 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Landscapes
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12487879A JPS5646812A (en) | 1979-09-27 | 1979-09-27 | Central nervous system depressant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12487879A JPS5646812A (en) | 1979-09-27 | 1979-09-27 | Central nervous system depressant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5646812A true JPS5646812A (en) | 1981-04-28 |
| JPH0212204B2 JPH0212204B2 (enrdf_load_stackoverflow) | 1990-03-19 |
Family
ID=14896321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12487879A Granted JPS5646812A (en) | 1979-09-27 | 1979-09-27 | Central nervous system depressant |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5646812A (enrdf_load_stackoverflow) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02191256A (ja) * | 1988-10-31 | 1990-07-27 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
| JPH04352723A (ja) * | 1991-05-31 | 1992-12-07 | Otsuka Pharmaceut Co Ltd | アカシジア治療剤 |
| JPH05279256A (ja) * | 1991-04-03 | 1993-10-26 | Otsuka Pharmaceut Co Ltd | 血小板凝集抑制剤 |
| WO1995011239A1 (fr) * | 1993-10-22 | 1995-04-27 | Santen Pharmaceutical Co., Ltd. | Nouveau derive de phenoxyalkylpiperazine |
| JPH07165720A (ja) * | 1988-10-31 | 1995-06-27 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
| JPH07304741A (ja) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
| JPH07304740A (ja) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JPH1045717A (ja) * | 1988-10-31 | 1998-02-17 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JP2007297405A (ja) * | 2001-01-29 | 2007-11-15 | Otsuka Pharmaceut Co Ltd | ５−ｈｔ１ａ受容体サブタイプ作動薬 |
| JP2011520815A (ja) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | 精神神経障害治療のためのｎｍｄａ受容体拮抗薬 |
| US8017615B2 (en) | 2001-09-25 | 2011-09-13 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US8030312B2 (en) | 2001-01-29 | 2011-10-04 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
| US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| USRE48059E1 (en) | 2005-04-14 | 2020-06-23 | Otsuka Pharmaceutical Co., Ltd. | Piperazine-substituted benzothiophenes for treatment of mental disorders |
-
1979
- 1979-09-27 JP JP12487879A patent/JPS5646812A/ja active Granted
Cited By (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02191256A (ja) * | 1988-10-31 | 1990-07-27 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
| JPH07165720A (ja) * | 1988-10-31 | 1995-06-27 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
| JPH1045717A (ja) * | 1988-10-31 | 1998-02-17 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JPH05279256A (ja) * | 1991-04-03 | 1993-10-26 | Otsuka Pharmaceut Co Ltd | 血小板凝集抑制剤 |
| JPH04352723A (ja) * | 1991-05-31 | 1992-12-07 | Otsuka Pharmaceut Co Ltd | アカシジア治療剤 |
| WO1995011239A1 (fr) * | 1993-10-22 | 1995-04-27 | Santen Pharmaceutical Co., Ltd. | Nouveau derive de phenoxyalkylpiperazine |
| JPH07304741A (ja) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
| JPH07304740A (ja) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| US8623874B2 (en) | 2001-01-29 | 2014-01-07 | Otsuka Pharmaceutical Co., Ltd. | Method of treating neurodegenerative diseases |
| US8680105B2 (en) | 2001-01-29 | 2014-03-25 | Otsuka Pharmaceutical Co., Ltd. | Method of treating down's syndrome |
| US9387207B2 (en) | 2001-01-29 | 2016-07-12 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
| US8030312B2 (en) | 2001-01-29 | 2011-10-04 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
| US9089567B2 (en) | 2001-01-29 | 2015-07-28 | Otsuka Pharmaceutical Co., Ltd. | Method of treating cognitive impairments and schizophrenias |
| US8426423B2 (en) | 2001-01-29 | 2013-04-23 | Otsuka Pharmaceutical Co., Ltd. | Method of treating Attention Deficit Hyper-Activity Disorder |
| US9006248B2 (en) | 2001-01-29 | 2015-04-14 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
| US8604041B2 (en) | 2001-01-29 | 2013-12-10 | Otsuka Pharmaceutical Co., Ltd. | Method of treating panic disorder |
| JP2007297405A (ja) * | 2001-01-29 | 2007-11-15 | Otsuka Pharmaceut Co Ltd | ５−ｈｔ１ａ受容体サブタイプ作動薬 |
| US8642600B2 (en) | 2001-01-29 | 2014-02-04 | Otsuka Pharmaceutical Co., Ltd. | Method of treating autism |
| US8722680B2 (en) | 2001-01-29 | 2014-05-13 | Otsuka Pharmaceutical Co., Ltd. | Method of treating neurodegenerative diseases |
| US8580796B2 (en) | 2001-09-25 | 2013-11-12 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US8703773B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US8642760B2 (en) | 2001-09-25 | 2014-02-04 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US8901303B2 (en) | 2001-09-25 | 2014-12-02 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US8901130B2 (en) | 2001-09-25 | 2014-12-02 | Ostuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation |
| US8993761B2 (en) | 2001-09-25 | 2015-03-31 | Otsuka Pharamceutical Co. Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US8399469B2 (en) | 2001-09-25 | 2013-03-19 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US9359302B2 (en) | 2001-09-25 | 2016-06-07 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US8017615B2 (en) | 2001-09-25 | 2011-09-13 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| US10150735B2 (en) | 2001-09-25 | 2018-12-11 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
| USRE48059E1 (en) | 2005-04-14 | 2020-06-23 | Otsuka Pharmaceutical Co., Ltd. | Piperazine-substituted benzothiophenes for treatment of mental disorders |
| JP2011520815A (ja) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | 精神神経障害治療のためのｎｍｄａ受容体拮抗薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0212204B2 (enrdf_load_stackoverflow) | 1990-03-19 |
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