JPS56169672A - Preparation of 2-chloro-3-cyanopyridine and 2- chloronicotinic acid - Google Patents
Preparation of 2-chloro-3-cyanopyridine and 2- chloronicotinic acidInfo
- Publication number
- JPS56169672A JPS56169672A JP7471880A JP7471880A JPS56169672A JP S56169672 A JPS56169672 A JP S56169672A JP 7471880 A JP7471880 A JP 7471880A JP 7471880 A JP7471880 A JP 7471880A JP S56169672 A JPS56169672 A JP S56169672A
- Authority
- JP
- Japan
- Prior art keywords
- cyanopyridine
- raw material
- resultant
- chloro
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JAUPUQRPBNDMDT-UHFFFAOYSA-N 2-chloropyridine-3-carbonitrile Chemical compound ClC1=NC=CC=C1C#N JAUPUQRPBNDMDT-UHFFFAOYSA-N 0.000 title abstract 2
- IBRSSZOHCGUTHI-UHFFFAOYSA-N 2-chloropyridine-3-carboxylic acid Chemical compound OC(=O)C1=CC=CN=C1Cl IBRSSZOHCGUTHI-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000002994 raw material Substances 0.000 abstract 3
- WOOVSQCALYYUDO-UHFFFAOYSA-N 1-oxidopyridin-1-ium-3-carbonitrile Chemical compound [O-][N+]1=CC=CC(C#N)=C1 WOOVSQCALYYUDO-UHFFFAOYSA-N 0.000 abstract 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 150000003222 pyridines Chemical class 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 1
- RCJVRSBWZCNNQT-UHFFFAOYSA-N dichloridooxygen Chemical compound ClOCl RCJVRSBWZCNNQT-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960003512 nicotinic acid Drugs 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
- 235000011121 sodium hydroxide Nutrition 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7471880A JPS56169672A (en) | 1980-06-02 | 1980-06-02 | Preparation of 2-chloro-3-cyanopyridine and 2- chloronicotinic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7471880A JPS56169672A (en) | 1980-06-02 | 1980-06-02 | Preparation of 2-chloro-3-cyanopyridine and 2- chloronicotinic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56169672A true JPS56169672A (en) | 1981-12-26 |
| JPS632262B2 JPS632262B2 (enrdf_load_stackoverflow) | 1988-01-18 |
Family
ID=13555273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7471880A Granted JPS56169672A (en) | 1980-06-02 | 1980-06-02 | Preparation of 2-chloro-3-cyanopyridine and 2- chloronicotinic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56169672A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59144759A (ja) * | 1983-02-07 | 1984-08-18 | Yuki Gosei Yakuhin Kogyo Kk | ２−クロロニコチン酸の製造方法 |
| US4504665A (en) * | 1982-04-12 | 1985-03-12 | Ishihara Sangyo Kaisha Ltd. | Process for producing chloronicotinic acid compounds |
| CN101117332B (zh) | 2006-08-04 | 2012-03-28 | 浙江医药股份有限公司新昌制药厂 | 2-氯烟酸的制备方法 |
| CN104072409A (zh) * | 2014-06-27 | 2014-10-01 | 温州大学 | 一种吡啶酰胺类化合物的合成方法 |
| CN109836376A (zh) * | 2019-04-10 | 2019-06-04 | 江苏汉阔生物有限公司 | 一种以2，3-吡啶二羧酸为原料制备2-氯代烟酸的方法 |
-
1980
- 1980-06-02 JP JP7471880A patent/JPS56169672A/ja active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4504665A (en) * | 1982-04-12 | 1985-03-12 | Ishihara Sangyo Kaisha Ltd. | Process for producing chloronicotinic acid compounds |
| JPS59144759A (ja) * | 1983-02-07 | 1984-08-18 | Yuki Gosei Yakuhin Kogyo Kk | ２−クロロニコチン酸の製造方法 |
| CN101117332B (zh) | 2006-08-04 | 2012-03-28 | 浙江医药股份有限公司新昌制药厂 | 2-氯烟酸的制备方法 |
| CN104072409A (zh) * | 2014-06-27 | 2014-10-01 | 温州大学 | 一种吡啶酰胺类化合物的合成方法 |
| CN109836376A (zh) * | 2019-04-10 | 2019-06-04 | 江苏汉阔生物有限公司 | 一种以2，3-吡啶二羧酸为原料制备2-氯代烟酸的方法 |
| CN109836376B (zh) * | 2019-04-10 | 2022-03-22 | 江苏汉阔生物有限公司 | 一种以2，3-吡啶二羧酸为原料制备2-氯代烟酸的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS632262B2 (enrdf_load_stackoverflow) | 1988-01-18 |
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