JPS56154419A - Heat treatment of alpha-fetoprotein-containing aqueous solution - Google Patents
Heat treatment of alpha-fetoprotein-containing aqueous solutionInfo
- Publication number
- JPS56154419A JPS56154419A JP5831880A JP5831880A JPS56154419A JP S56154419 A JPS56154419 A JP S56154419A JP 5831880 A JP5831880 A JP 5831880A JP 5831880 A JP5831880 A JP 5831880A JP S56154419 A JPS56154419 A JP S56154419A
- Authority
- JP
- Japan
- Prior art keywords
- fetoprotein
- aqueous solution
- afp
- deactivate
- solution containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
PURPOSE: An aqueous solution containing α-fetoprotein is heat treated in the presence of a specific stabilizer to deactivate hepatitis virus with no deactivation of the α-fetoprotein.
CONSTITUTION: An aqueous solution containing α-fetoprotein (abbreviated to AFP hereinafter) is heat treated at 50W80°C to deactivate the hapatitis virus included therein wherein at least one selected from 2W5C aliphatic aminoacids, monosaccharides and saccharide alcohols such as glycine, glucose, mannitol is added by 10W30%W/V or at least one selected from 6W15C aminoacids, 3W10C organic carboxylic acids and their esters such as acetyltriptophane or sodium caprylate is added as a stabilizer and the treatment is effected for 3W15hr. AFP occurs in the ascites and serum of primary hepatoma patients in high concentration and is used as a raw material for preparing antiAFP antibody that is used for treating and preventing AFP-producing cancers and as a hepatoma diagnosticum.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5831880A JPS56154419A (en) | 1980-04-30 | 1980-04-30 | Heat treatment of alpha-fetoprotein-containing aqueous solution |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5831880A JPS56154419A (en) | 1980-04-30 | 1980-04-30 | Heat treatment of alpha-fetoprotein-containing aqueous solution |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56154419A true JPS56154419A (en) | 1981-11-30 |
JPH0348168B2 JPH0348168B2 (en) | 1991-07-23 |
Family
ID=13080914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5831880A Granted JPS56154419A (en) | 1980-04-30 | 1980-04-30 | Heat treatment of alpha-fetoprotein-containing aqueous solution |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56154419A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6094917A (en) * | 1983-10-28 | 1985-05-28 | Green Cross Corp:The | Production of vaccine for preventing infection to hepatitis b |
JPH05306236A (en) * | 1982-07-30 | 1993-11-19 | Behringwerke Ag | Preparation of medicine containing c1 inactivator |
WO2001064241A1 (en) * | 2000-02-29 | 2001-09-07 | Chugai Seiyaku Kabushiki Kaisha | Preparations stabilized over long time |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51118819A (en) * | 1975-04-08 | 1976-10-19 | Green Cross Corp:The | A process for preparing heat stable antitrypsin |
JPS51118820A (en) * | 1975-04-08 | 1976-10-19 | Green Cross Corp:The | A process for preparing heat stable macroglobulin |
JPS5359018A (en) * | 1976-11-10 | 1978-05-27 | Green Cross Corp:The | Concentrated xiii-th blood coagulating factor derived from human placentaand its preparation |
JPS5377527A (en) * | 1977-10-31 | 1978-07-10 | Konishiroku Photo Ind Co Ltd | Color photographic material containing dye image antidiscolorant |
-
1980
- 1980-04-30 JP JP5831880A patent/JPS56154419A/en active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51118819A (en) * | 1975-04-08 | 1976-10-19 | Green Cross Corp:The | A process for preparing heat stable antitrypsin |
JPS51118820A (en) * | 1975-04-08 | 1976-10-19 | Green Cross Corp:The | A process for preparing heat stable macroglobulin |
JPS5359018A (en) * | 1976-11-10 | 1978-05-27 | Green Cross Corp:The | Concentrated xiii-th blood coagulating factor derived from human placentaand its preparation |
JPS5377527A (en) * | 1977-10-31 | 1978-07-10 | Konishiroku Photo Ind Co Ltd | Color photographic material containing dye image antidiscolorant |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05306236A (en) * | 1982-07-30 | 1993-11-19 | Behringwerke Ag | Preparation of medicine containing c1 inactivator |
JPS6094917A (en) * | 1983-10-28 | 1985-05-28 | Green Cross Corp:The | Production of vaccine for preventing infection to hepatitis b |
WO2001064241A1 (en) * | 2000-02-29 | 2001-09-07 | Chugai Seiyaku Kabushiki Kaisha | Preparations stabilized over long time |
US7163671B2 (en) | 2000-02-29 | 2007-01-16 | Chugai Seiyaku Kabushiki Kaisha | Long-term stabilized formulations |
JP4683810B2 (en) * | 2000-02-29 | 2011-05-18 | 中外製薬株式会社 | Long-term stabilized preparation |
Also Published As
Publication number | Publication date |
---|---|
JPH0348168B2 (en) | 1991-07-23 |
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