JPS56154419A - Heat treatment of alpha-fetoprotein-containing aqueous solution - Google Patents

Heat treatment of alpha-fetoprotein-containing aqueous solution

Info

Publication number
JPS56154419A
JPS56154419A JP5831880A JP5831880A JPS56154419A JP S56154419 A JPS56154419 A JP S56154419A JP 5831880 A JP5831880 A JP 5831880A JP 5831880 A JP5831880 A JP 5831880A JP S56154419 A JPS56154419 A JP S56154419A
Authority
JP
Japan
Prior art keywords
fetoprotein
aqueous solution
afp
deactivate
solution containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5831880A
Other languages
Japanese (ja)
Other versions
JPH0348168B2 (en
Inventor
Tsunekazu Fukushima
Mitsugi Fujii
Satoru Funakoshi
Tadakazu Suyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP5831880A priority Critical patent/JPS56154419A/en
Publication of JPS56154419A publication Critical patent/JPS56154419A/en
Publication of JPH0348168B2 publication Critical patent/JPH0348168B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: An aqueous solution containing α-fetoprotein is heat treated in the presence of a specific stabilizer to deactivate hepatitis virus with no deactivation of the α-fetoprotein.
CONSTITUTION: An aqueous solution containing α-fetoprotein (abbreviated to AFP hereinafter) is heat treated at 50W80°C to deactivate the hapatitis virus included therein wherein at least one selected from 2W5C aliphatic aminoacids, monosaccharides and saccharide alcohols such as glycine, glucose, mannitol is added by 10W30%W/V or at least one selected from 6W15C aminoacids, 3W10C organic carboxylic acids and their esters such as acetyltriptophane or sodium caprylate is added as a stabilizer and the treatment is effected for 3W15hr. AFP occurs in the ascites and serum of primary hepatoma patients in high concentration and is used as a raw material for preparing antiAFP antibody that is used for treating and preventing AFP-producing cancers and as a hepatoma diagnosticum.
COPYRIGHT: (C)1981,JPO&Japio
JP5831880A 1980-04-30 1980-04-30 Heat treatment of alpha-fetoprotein-containing aqueous solution Granted JPS56154419A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5831880A JPS56154419A (en) 1980-04-30 1980-04-30 Heat treatment of alpha-fetoprotein-containing aqueous solution

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5831880A JPS56154419A (en) 1980-04-30 1980-04-30 Heat treatment of alpha-fetoprotein-containing aqueous solution

Publications (2)

Publication Number Publication Date
JPS56154419A true JPS56154419A (en) 1981-11-30
JPH0348168B2 JPH0348168B2 (en) 1991-07-23

Family

ID=13080914

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5831880A Granted JPS56154419A (en) 1980-04-30 1980-04-30 Heat treatment of alpha-fetoprotein-containing aqueous solution

Country Status (1)

Country Link
JP (1) JPS56154419A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6094917A (en) * 1983-10-28 1985-05-28 Green Cross Corp:The Production of vaccine for preventing infection to hepatitis b
JPH05306236A (en) * 1982-07-30 1993-11-19 Behringwerke Ag Preparation of medicine containing c1 inactivator
WO2001064241A1 (en) * 2000-02-29 2001-09-07 Chugai Seiyaku Kabushiki Kaisha Preparations stabilized over long time

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118819A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable antitrypsin
JPS51118820A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable macroglobulin
JPS5359018A (en) * 1976-11-10 1978-05-27 Green Cross Corp:The Concentrated xiii-th blood coagulating factor derived from human placentaand its preparation
JPS5377527A (en) * 1977-10-31 1978-07-10 Konishiroku Photo Ind Co Ltd Color photographic material containing dye image antidiscolorant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51118819A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable antitrypsin
JPS51118820A (en) * 1975-04-08 1976-10-19 Green Cross Corp:The A process for preparing heat stable macroglobulin
JPS5359018A (en) * 1976-11-10 1978-05-27 Green Cross Corp:The Concentrated xiii-th blood coagulating factor derived from human placentaand its preparation
JPS5377527A (en) * 1977-10-31 1978-07-10 Konishiroku Photo Ind Co Ltd Color photographic material containing dye image antidiscolorant

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05306236A (en) * 1982-07-30 1993-11-19 Behringwerke Ag Preparation of medicine containing c1 inactivator
JPS6094917A (en) * 1983-10-28 1985-05-28 Green Cross Corp:The Production of vaccine for preventing infection to hepatitis b
WO2001064241A1 (en) * 2000-02-29 2001-09-07 Chugai Seiyaku Kabushiki Kaisha Preparations stabilized over long time
US7163671B2 (en) 2000-02-29 2007-01-16 Chugai Seiyaku Kabushiki Kaisha Long-term stabilized formulations
JP4683810B2 (en) * 2000-02-29 2011-05-18 中外製薬株式会社 Long-term stabilized preparation

Also Published As

Publication number Publication date
JPH0348168B2 (en) 1991-07-23

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