JPS56140974A - Novel imidazole derivative - Google Patents
Novel imidazole derivativeInfo
- Publication number
- JPS56140974A JPS56140974A JP4416280A JP4416280A JPS56140974A JP S56140974 A JPS56140974 A JP S56140974A JP 4416280 A JP4416280 A JP 4416280A JP 4416280 A JP4416280 A JP 4416280A JP S56140974 A JPS56140974 A JP S56140974A
- Authority
- JP
- Japan
- Prior art keywords
- action
- formula
- carbamoyl
- addition salt
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- -1 cinnamoyl Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 230000003327 cancerostatic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000006268 Sarcoma 180 Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229940049964 oleate Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An imidazole derivative expressed by formula I (A is cinnamoyl unsubstituted or substituted by a substituent selected from alkyl, alkoxyl, aryl, nitro, methylenedioxy, formyl, halogenoalkyl, halogen, amino, OH, carboxyl and cyano on the benzene ring or/and at the 2-position) and an acid addition salt thereof.
EXAMPLE: 5-Carbamoyl-1H-imidazol-4-ylcinnamate.
USE: A carcinostatic agent having improved carcinostatic action, immunosuppressive action, antimicrobial action, antifungal action, antiviral action and antirheumatic action, and further a powerful inhibitory action on the multiplication of tumor cells of Sarcoma-180, etc.
PROCESS: 4-Carbamoyl-imidazolium-5-oleate or a reactive derivative thereof is reacted with a carboxylic acid of formula II or a reactive derivative thereof to give the compound of formula I and an acid addition salt thereof.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4416280A JPS56140974A (en) | 1980-04-03 | 1980-04-03 | Novel imidazole derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4416280A JPS56140974A (en) | 1980-04-03 | 1980-04-03 | Novel imidazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56140974A true JPS56140974A (en) | 1981-11-04 |
Family
ID=12683898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4416280A Pending JPS56140974A (en) | 1980-04-03 | 1980-04-03 | Novel imidazole derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56140974A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6577471B1 (en) | 1998-07-17 | 2003-06-10 | Fuji Photo Film Co., Ltd. | Magnetic tape cartridge |
| WO2008062466A2 (en) * | 2006-10-13 | 2008-05-29 | Reliance Life Sciences Pvt. Ltd. | Cinnamic acid, vanillic acid and benzofuran derivatives for use in the treatment of inflammation and cancer |
-
1980
- 1980-04-03 JP JP4416280A patent/JPS56140974A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6577471B1 (en) | 1998-07-17 | 2003-06-10 | Fuji Photo Film Co., Ltd. | Magnetic tape cartridge |
| WO2008062466A2 (en) * | 2006-10-13 | 2008-05-29 | Reliance Life Sciences Pvt. Ltd. | Cinnamic acid, vanillic acid and benzofuran derivatives for use in the treatment of inflammation and cancer |
| WO2008062466A3 (en) * | 2006-10-13 | 2008-09-25 | Reliance Life Sciences Pvt Ltd | Cinnamic acid, vanillic acid and benzofuran derivatives for use in the treatment of inflammation and cancer |
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