JPS56140976A - Novel imidazole derivative - Google Patents
Novel imidazole derivativeInfo
- Publication number
- JPS56140976A JPS56140976A JP4504280A JP4504280A JPS56140976A JP S56140976 A JPS56140976 A JP S56140976A JP 4504280 A JP4504280 A JP 4504280A JP 4504280 A JP4504280 A JP 4504280A JP S56140976 A JPS56140976 A JP S56140976A
- Authority
- JP
- Japan
- Prior art keywords
- action
- formula
- carbamoyl
- halogen
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- -1 amino, carboxyl Chemical group 0.000 abstract 2
- 230000003327 cancerostatic effect Effects 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000006268 Sarcoma 180 Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229940049964 oleate Drugs 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An imidazole derivative expressed by formula I (A is undubstituted or substituted cycloalkyl having a substitutent of lower alkyl, lower alkenyl, halogen, halogen substituted lower alkenyl, phenyl, halogen substituted phenyl, formyl, OH, amino, carboxyl, aminomethyl, oxo, etc.) and an acid addition salt thereof.
EXAMPLE: 5-Carbamoyl-1H-imidazol-4-yl cyclopropane-1'-carboxylate.
USE: A carcinostatic agent having improved carcinostatic action, immunosuppressive action, antimicrobial action, antifungal action, antiviral action and antirheumatic action, and further powerful inhibitory action on the multiplication of tumor cells of Sarcoma-180, etc.
PROCESS: 4-Carbamoyl-imidazolium-5-oleate or a reactive derivative thereof is reacted with a carboxylic acid of formula II a reactive derivative thereof to give the compound of formula I and an acid addition salt thereof.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4504280A JPS56140976A (en) | 1980-04-04 | 1980-04-04 | Novel imidazole derivative |
| AU60947/80A AU530916B2 (en) | 1979-08-08 | 1980-07-31 | 4-carbamoyl imidazolium-5-olate derivatives |
| CA000357556A CA1151651A (en) | 1979-08-08 | 1980-08-01 | Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate derivatives, pharmaceutical composition and production thereof |
| US06/175,688 US4317825A (en) | 1979-08-08 | 1980-08-05 | Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate derivatives |
| DK340480A DK340480A (en) | 1979-08-08 | 1980-08-07 | 4-CARBAMOYLIMIDAZOLIUM-5-OLATE DERIVATIVES AND THEIR PREPARATION AND USE |
| DE8080302716T DE3063136D1 (en) | 1979-08-08 | 1980-08-07 | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives, pharmaceutical composition and production thereof |
| EP80302716A EP0024172B1 (en) | 1979-08-08 | 1980-08-07 | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives, pharmaceutical composition and production thereof |
| AT80302716T ATE3287T1 (en) | 1979-08-08 | 1980-08-07 | ANTITUMORIC AND IMMUNOSUPPRESSIVE 4CARBAMOYLIMIDAZOLIUM-5-OLATE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND THEIR PREPARATION. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4504280A JPS56140976A (en) | 1980-04-04 | 1980-04-04 | Novel imidazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56140976A true JPS56140976A (en) | 1981-11-04 |
Family
ID=12708303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4504280A Pending JPS56140976A (en) | 1979-08-08 | 1980-04-04 | Novel imidazole derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56140976A (en) |
-
1980
- 1980-04-04 JP JP4504280A patent/JPS56140976A/en active Pending
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