JPS56140970A - Preparation of indole derivative - Google Patents

Preparation of indole derivative

Info

Publication number
JPS56140970A
JPS56140970A JP4363380A JP4363380A JPS56140970A JP S56140970 A JPS56140970 A JP S56140970A JP 4363380 A JP4363380 A JP 4363380A JP 4363380 A JP4363380 A JP 4363380A JP S56140970 A JPS56140970 A JP S56140970A
Authority
JP
Japan
Prior art keywords
hydroxy
formula
trimethylsilyloxyindole
isopropylaminopropyl
halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4363380A
Other languages
Japanese (ja)
Inventor
Nobuo Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RONZA CHEM KK
RONZA CHEMICAL KK
Original Assignee
RONZA CHEM KK
RONZA CHEMICAL KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RONZA CHEM KK, RONZA CHEMICAL KK filed Critical RONZA CHEM KK
Priority to JP4363380A priority Critical patent/JPS56140970A/en
Publication of JPS56140970A publication Critical patent/JPS56140970A/en
Pending legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound which is a hypotensive agent, etc. directly, by reacting a stable silylhydroxyindole derivative with a 2-hydroxy-3-isopropylaminopropyl halide in the presence of a quaternary ammonium fluoride.
CONSTITUTION: 4-Trimethylsilyloxyindole is selectively activated with a quaternary ammonium fluoride of the formula (R)4NF (R is alkyl or allyl) at the 4-oxo position thereof, and then reacted with a 2-hydroxy-3-isopropylaminopropyl halide of formula I (X is Cl, Br or I) under neutral conditions without protecting the benzyl group to give 4-[2-hydroxy-3-(isopropylamino)-propoxy]indole of formula II. The raw material 4-trimethylsilyloxyindole is obtained by treating 4-hydroxyindole with a silylating agent.
USE: A remedy for extrasystolic abnormality.
COPYRIGHT: (C)1981,JPO&Japio
JP4363380A 1980-04-04 1980-04-04 Preparation of indole derivative Pending JPS56140970A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4363380A JPS56140970A (en) 1980-04-04 1980-04-04 Preparation of indole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4363380A JPS56140970A (en) 1980-04-04 1980-04-04 Preparation of indole derivative

Publications (1)

Publication Number Publication Date
JPS56140970A true JPS56140970A (en) 1981-11-04

Family

ID=12669257

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4363380A Pending JPS56140970A (en) 1980-04-04 1980-04-04 Preparation of indole derivative

Country Status (1)

Country Link
JP (1) JPS56140970A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5175095A (en) * 1974-12-24 1976-06-29 Nippon Soda Co 22 merukaputo 66 hidorokishipurinno seizoho
JPS5195064A (en) * 1975-02-11 1976-08-20 **** *tsu*****na*tsu************* ****************ne*******i*****hi***e
JPS52125163A (en) * 1976-04-14 1977-10-20 Otsuka Pharmaceut Co Ltd Novel benzcyclamide derivatives
JPS54160389A (en) * 1978-06-06 1979-12-19 Hoechst Ag Novel substituted phenylpiperazine derivative and its manufacture

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5175095A (en) * 1974-12-24 1976-06-29 Nippon Soda Co 22 merukaputo 66 hidorokishipurinno seizoho
JPS5195064A (en) * 1975-02-11 1976-08-20 **** *tsu*****na*tsu************* ****************ne*******i*****hi***e
JPS52125163A (en) * 1976-04-14 1977-10-20 Otsuka Pharmaceut Co Ltd Novel benzcyclamide derivatives
JPS54160389A (en) * 1978-06-06 1979-12-19 Hoechst Ag Novel substituted phenylpiperazine derivative and its manufacture

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