JPS56128762A - Preparation of 5,6-dihalogeno-2-alkylquinoline - Google Patents

Preparation of 5,6-dihalogeno-2-alkylquinoline

Info

Publication number
JPS56128762A
JPS56128762A JP3293080A JP3293080A JPS56128762A JP S56128762 A JPS56128762 A JP S56128762A JP 3293080 A JP3293080 A JP 3293080A JP 3293080 A JP3293080 A JP 3293080A JP S56128762 A JPS56128762 A JP S56128762A
Authority
JP
Japan
Prior art keywords
compound
formula
agent
antimicrobial agent
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3293080A
Other languages
Japanese (ja)
Other versions
JPS645024B2 (en
Inventor
Hiroshi Ishikawa
Masanobu Kano
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP3293080A priority Critical patent/JPS56128762A/en
Publication of JPS56128762A publication Critical patent/JPS56128762A/en
Publication of JPS645024B2 publication Critical patent/JPS645024B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled substance useful as an antimicrobial agent, antimalarial agent or an intermediate for the antimicrobial agent in high purity and high yield, by reacting a 6-halogeno-2-alkylquinoline with a halogenating agent, e.g. chlorine or bromine.
CONSTITUTION: A compound expressed by formula I (R is lower alkyl; X1 is halogen) is reacted with a halogenating agent in a molar amount 1W2 times that of the compound of formula I to give a compound of formula II (X2 is halogen). The reaction is carried out in an inert solvent or under solventless conditions. In the case of an inert solvent, the compound is reacted with the halogenating agent in a solvent, e.g. sulfuric acid, nitric acid, dioxane or methylene chloride, in the presence of a metallic sulfate, e.g. silver sulfate, or a metallic salt of a Lewis acid, in the reaction system at 0W50°C. In the case of solventless conditions, a large excess of the Lewis acid is used to make the reaction proceed at 110W130°C.
USE: An intermediate for a compound of formula III useful as an antimicrobial agent.
COPYRIGHT: (C)1981,JPO&Japio
JP3293080A 1980-03-14 1980-03-14 Preparation of 5,6-dihalogeno-2-alkylquinoline Granted JPS56128762A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3293080A JPS56128762A (en) 1980-03-14 1980-03-14 Preparation of 5,6-dihalogeno-2-alkylquinoline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3293080A JPS56128762A (en) 1980-03-14 1980-03-14 Preparation of 5,6-dihalogeno-2-alkylquinoline

Publications (2)

Publication Number Publication Date
JPS56128762A true JPS56128762A (en) 1981-10-08
JPS645024B2 JPS645024B2 (en) 1989-01-27

Family

ID=12372631

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3293080A Granted JPS56128762A (en) 1980-03-14 1980-03-14 Preparation of 5,6-dihalogeno-2-alkylquinoline

Country Status (1)

Country Link
JP (1) JPS56128762A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568750A (en) * 1983-03-17 1986-02-04 Riker Laboratories, Inc. Precursors of 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4876898A (en) * 1971-12-30 1973-10-16
JPS5445338A (en) * 1977-09-19 1979-04-10 Nippon Chem Ind Co Ltd:The Production of quinophthalone pigment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4876898A (en) * 1971-12-30 1973-10-16
JPS5445338A (en) * 1977-09-19 1979-04-10 Nippon Chem Ind Co Ltd:The Production of quinophthalone pigment

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568750A (en) * 1983-03-17 1986-02-04 Riker Laboratories, Inc. Precursors of 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu

Also Published As

Publication number Publication date
JPS645024B2 (en) 1989-01-27

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