JPS56128762A - Preparation of 5,6-dihalogeno-2-alkylquinoline - Google Patents
Preparation of 5,6-dihalogeno-2-alkylquinolineInfo
- Publication number
- JPS56128762A JPS56128762A JP3293080A JP3293080A JPS56128762A JP S56128762 A JPS56128762 A JP S56128762A JP 3293080 A JP3293080 A JP 3293080A JP 3293080 A JP3293080 A JP 3293080A JP S56128762 A JPS56128762 A JP S56128762A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- agent
- antimicrobial agent
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled substance useful as an antimicrobial agent, antimalarial agent or an intermediate for the antimicrobial agent in high purity and high yield, by reacting a 6-halogeno-2-alkylquinoline with a halogenating agent, e.g. chlorine or bromine.
CONSTITUTION: A compound expressed by formula I (R is lower alkyl; X1 is halogen) is reacted with a halogenating agent in a molar amount 1W2 times that of the compound of formula I to give a compound of formula II (X2 is halogen). The reaction is carried out in an inert solvent or under solventless conditions. In the case of an inert solvent, the compound is reacted with the halogenating agent in a solvent, e.g. sulfuric acid, nitric acid, dioxane or methylene chloride, in the presence of a metallic sulfate, e.g. silver sulfate, or a metallic salt of a Lewis acid, in the reaction system at 0W50°C. In the case of solventless conditions, a large excess of the Lewis acid is used to make the reaction proceed at 110W130°C.
USE: An intermediate for a compound of formula III useful as an antimicrobial agent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3293080A JPS56128762A (en) | 1980-03-14 | 1980-03-14 | Preparation of 5,6-dihalogeno-2-alkylquinoline |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3293080A JPS56128762A (en) | 1980-03-14 | 1980-03-14 | Preparation of 5,6-dihalogeno-2-alkylquinoline |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56128762A true JPS56128762A (en) | 1981-10-08 |
JPS645024B2 JPS645024B2 (en) | 1989-01-27 |
Family
ID=12372631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3293080A Granted JPS56128762A (en) | 1980-03-14 | 1980-03-14 | Preparation of 5,6-dihalogeno-2-alkylquinoline |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56128762A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4568750A (en) * | 1983-03-17 | 1986-02-04 | Riker Laboratories, Inc. | Precursors of 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4876898A (en) * | 1971-12-30 | 1973-10-16 | ||
JPS5445338A (en) * | 1977-09-19 | 1979-04-10 | Nippon Chem Ind Co Ltd:The | Production of quinophthalone pigment |
-
1980
- 1980-03-14 JP JP3293080A patent/JPS56128762A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4876898A (en) * | 1971-12-30 | 1973-10-16 | ||
JPS5445338A (en) * | 1977-09-19 | 1979-04-10 | Nippon Chem Ind Co Ltd:The | Production of quinophthalone pigment |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4568750A (en) * | 1983-03-17 | 1986-02-04 | Riker Laboratories, Inc. | Precursors of 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu |
Also Published As
Publication number | Publication date |
---|---|
JPS645024B2 (en) | 1989-01-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2442227A1 (en) | PROCESS FOR THE PRODUCTION OF THREO-3-AMINO-2-HYDROXYBUTANOYLAMINOACETIC ACIDS | |
GB1604164A (en) | Diamino-thiocyanotobenzene derivatives and their preparation | |
JPS55120549A (en) | Preparation of 2-chloro-6-nitrobenzonitrile | |
FI904393A0 (en) | FOERBAETTRAT FOERFARANDE FOER FRAMSTAELLNING AV AMIDOXIMDERIVAT. | |
JPS56128762A (en) | Preparation of 5,6-dihalogeno-2-alkylquinoline | |
JPS55162763A (en) | Perfluoroalkyl compound and its preparation | |
ES8203315A1 (en) | Process for the preparation of vinyl-stilbene compounds. | |
JPS57118535A (en) | Preparation of fluoroalkyl alpha-chloroacrylate | |
JPS5679662A (en) | Preparation of o-nitrobenzonitrile derivative | |
JPS56154483A (en) | Preparation or pyrrole derivative | |
IE43311B1 (en) | 1-methyl-2-(pyridyloxmyethyl)-5-nitroimidazoles and process for preparing them | |
JPS56123972A (en) | Preparation of 1,3-dialkyl-4-benzoyl-5-hydroxypyrazole compound | |
JPS56169674A (en) | Preparation of 1-substituted-4-benzoyl-5-hydroxy-3- methylpyrazole derivative | |
JPS5716892A (en) | Synthesis of n-trialkylsilylmethylurea | |
JPS5740497A (en) | Preparation of 5-halogeno-2'-deoxyuridine | |
JPS6431761A (en) | Polyhalogenoindoline derivative | |
JPS56167685A (en) | 1- 2-tetrahydrothiophene-1,1-dioxide -5-fluorouracil and its preparation | |
JPS572275A (en) | Preparation of 4-benzoylpyrazole-type compound | |
JPS56156259A (en) | Preparation of high-purity tolyltioureas | |
JPS5639090A (en) | 5-substituted uracil derivative and its preparation | |
JPS5511503A (en) | Condensed heterocyclic compound | |
JPS56158744A (en) | Preparation of ortho- 2,6-dichloroanilino -phenylacetic acid or its salt | |
JPS6419003A (en) | Highly selective herbicide and one process manufacture of two active component composition | |
JPS5629526A (en) | Preparation of acylcyanide | |
JPS5714598A (en) | 5-substituted-1-beta-d-arabinofuranosyluracil derivative and its preparation |