JPS56122374A - Hypocholesterolemic hydrogenation product and its manufacture - Google Patents
Hypocholesterolemic hydrogenation product and its manufactureInfo
- Publication number
- JPS56122374A JPS56122374A JP1447881A JP1447881A JPS56122374A JP S56122374 A JPS56122374 A JP S56122374A JP 1447881 A JP1447881 A JP 1447881A JP 1447881 A JP1447881 A JP 1447881A JP S56122374 A JPS56122374 A JP S56122374A
- Authority
- JP
- Japan
- Prior art keywords
- hypocholesterolemic
- manufacture
- hydrogenation
- hydrogenation product
- results
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005984 hydrogenation reaction Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000000871 hypocholesterolemic effect Effects 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 2
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
- IFIFFBWHLKGTMO-SJIDJMGWSA-N [(1s,3s,4ar,7s,8s,8as)-8-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2s)-2-methylbutanoate Chemical compound C([C@H]1[C@@H](C)C=C[C@H]2C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 IFIFFBWHLKGTMO-SJIDJMGWSA-N 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11805080A | 1980-02-04 | 1980-02-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56122374A true JPS56122374A (en) | 1981-09-25 |
| JPH0136471B2 JPH0136471B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-07-31 |
Family
ID=22376236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1447881A Granted JPS56122374A (en) | 1980-02-04 | 1981-02-04 | Hypocholesterolemic hydrogenation product and its manufacture |
Country Status (9)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57185274A (en) * | 1981-05-07 | 1982-11-15 | Sankyo Co Ltd | Tetrahydro-mb-530b and its derivative |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2739768A (en) * | 1954-09-27 | 1956-03-27 | August C Purpura | Aircraft having feathering airfoils |
| AU548996B2 (en) | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Ｍｂ−５３０ａ誘導体 |
| JPS57185276A (en) * | 1981-05-11 | 1982-11-15 | Sankyo Co Ltd | Dihydro-dum-4 and dihydro-isodum-4 and their derivative |
| DE3480923D1 (de) * | 1983-10-11 | 1990-02-08 | Merck & Co Inc | Verfahren zur c-methylierung von 2-methylbutyraten. |
| DE3481190D1 (de) * | 1983-10-11 | 1990-03-08 | Merck & Co Inc | Verfahren zur herstellung von 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)-2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)-decahydronaphthyl-1(s))ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-on. |
| US4885314A (en) * | 1987-06-29 | 1989-12-05 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| EP0306210B1 (en) * | 1987-09-03 | 1993-09-29 | Merck & Co. Inc. | A novel hydrogenation process for the formation of di or tetrahydro hmg-coa reductase inhibitors |
| US5089523A (en) * | 1990-05-11 | 1992-02-18 | E. R. Squibb & Sons, Inc. | Fluorinated derivatives of mevinic acids |
| US5250435A (en) * | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| JP4340386B2 (ja) * | 1997-08-28 | 2009-10-07 | ノバルティス アクチエンゲゼルシャフト | リンパ球機能抗原−１アンタゴニスト |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS559024A (en) * | 1978-07-04 | 1980-01-22 | Sankyo Co Ltd | Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4049495A (en) * | 1974-06-07 | 1977-09-20 | Sankyo Company Limited | Physiologically active substances and fermentative process for producing the same |
| JPS5612114B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1974-06-07 | 1981-03-18 | ||
| JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンｋおよびその製造法 |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| IL60219A (en) * | 1979-06-15 | 1985-05-31 | Merck & Co Inc | Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them |
-
1981
- 1981-01-23 PT PT72394A patent/PT72394B/pt unknown
- 1981-01-29 IE IE168/81A patent/IE51477B1/en unknown
- 1981-02-02 EP EP81100728A patent/EP0033537B1/en not_active Expired
- 1981-02-02 DE DE8181100728T patent/DE3170666D1/de not_active Expired
- 1981-02-02 GR GR64029A patent/GR73077B/el unknown
- 1981-02-02 AT AT81100728T patent/ATE13534T1/de not_active IP Right Cessation
- 1981-02-03 DK DK45981A patent/DK45981A/da not_active Application Discontinuation
- 1981-02-03 ES ES499078A patent/ES499078A0/es active Granted
- 1981-02-04 JP JP1447881A patent/JPS56122374A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS559024A (en) * | 1978-07-04 | 1980-01-22 | Sankyo Co Ltd | Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57185274A (en) * | 1981-05-07 | 1982-11-15 | Sankyo Co Ltd | Tetrahydro-mb-530b and its derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| ES8202550A1 (es) | 1982-02-01 |
| EP0033537A2 (en) | 1981-08-12 |
| IE810168L (en) | 1981-08-04 |
| ATE13534T1 (de) | 1985-06-15 |
| DK45981A (da) | 1981-08-05 |
| JPH0136471B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-07-31 |
| EP0033537A3 (en) | 1982-02-24 |
| GR73077B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-01-31 |
| IE51477B1 (en) | 1987-01-07 |
| ES499078A0 (es) | 1982-02-01 |
| PT72394A (en) | 1981-02-01 |
| EP0033537B1 (en) | 1985-05-29 |
| DE3170666D1 (en) | 1985-07-04 |
| PT72394B (en) | 1982-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS56122374A (en) | Hypocholesterolemic hydrogenation product and its manufacture | |
| AU577249B2 (en) | Chewable mineral supplement | |
| DE3474098D1 (en) | A dietary fibre food product and a process for the production of the same | |
| AU2894089A (en) | Process for the production of alkenyl-substituted benzene derivatives | |
| AU2294688A (en) | Process for the production and extraction of polysaccharides from a porphyridium cruentum culture and apparatus for performing the process | |
| DE3067380D1 (en) | Enzyme inhibitor produced by cultivation of a streptomyces microorganism, a process for producing it and a culture of the microorganism | |
| JPS6460602A (en) | Novel starch, product therefrom and production thereof | |
| CY1565A (en) | Novel pleuromutilin derivatives,process for their production and their use | |
| AU3469789A (en) | Tomatoes | |
| MY8600644A (en) | A enzyme for decomposition of a high molecular carbohydrate, the isolated high molecular carbohydrate, a method for selection of a microorganism producing such enzyme and a method for the production of such enzyme | |
| EP0370958A3 (en) | Heparinase-producing microorganism belonging to the genus bacillus, new heparinase and process for producing same | |
| AU3644489A (en) | Novel pigments, process for their production and their use | |
| MY8200143A (en) | Cereal based product and process for its production | |
| HU900498D0 (en) | Process for the production of fermented food products | |
| AU6559986A (en) | Process for producing fibrous food product | |
| AU6280686A (en) | Process for the production of a protein-vitamin food supplement from autotrophic micro-organism, in particular for alga spirulina | |
| GB2225922B (en) | A method for the manufacture of a fermented cereal product | |
| AU624690B2 (en) | A mutant of microbacterium, a strain 851r, and a process for producing 851 nutrient solution by application of the strain | |
| AU631663B2 (en) | A mutant of pseudomonas, a strain yzh, and a process for producing 851 yzh nutrient solution by application of the strain | |
| ES8102092A1 (es) | Procedimiento de preparacion de monohidrato de 1,25-dihidro-xi-colecalciferol | |
| ATE103899T1 (de) | Zwischenprodukte und verfahren zu ihrer herstellung. | |
| UA5567A1 (uk) | Спосіб отримання d-l-амінокислот | |
| EP0343388A3 (en) | Expression of interferon-gamma in methylotrophic yeasts | |
| EP0405511A3 (en) | Method for the suspension culture of haploid maize male gametophytes | |
| AU6763490A (en) | Pyridine-N-oxide derivative and process for its production |