JPS56118069A - 8,9-dihydroxyphenanthridinium salt - Google Patents

8,9-dihydroxyphenanthridinium salt

Info

Publication number
JPS56118069A
JPS56118069A JP2251780A JP2251780A JPS56118069A JP S56118069 A JPS56118069 A JP S56118069A JP 2251780 A JP2251780 A JP 2251780A JP 2251780 A JP2251780 A JP 2251780A JP S56118069 A JPS56118069 A JP S56118069A
Authority
JP
Japan
Prior art keywords
formula
compound
dihydroxyphenanthridinium
salt
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2251780A
Other languages
Japanese (ja)
Inventor
Yuichi Kaneoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP2251780A priority Critical patent/JPS56118069A/en
Publication of JPS56118069A publication Critical patent/JPS56118069A/en
Pending legal-status Critical Current

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  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 8,9-dihydroxyphenanthridinium salt of formula I (R1 is lower alkyl; X- is anion).
EXAMPLE: 8,9-Dihydroxy-5-methylphenanthridinium chloride.
USE: Useful as a carcinostatic agent.
PROCESS: 2,4,5-Trimethoxybenzoic acid is made to react with thionyl chloride in ether, and the reaction product is reacted with aniline. The resulting compound is irradiated with light in a solvent, and reacted with an alkyl halide of formula R1- Y(Y is halogen) in the presence of a base to obtain a compound of formula II, which is converted to a compound of formula III by the reaction with boron tribromide followed by hydrolysis. The compound of formula III is reduced in an inert solvent with a reducing agent to obtain a compound of formula IV, which is oxidized with air in a solvent containing a halogen acid to afford the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP2251780A 1980-02-25 1980-02-25 8,9-dihydroxyphenanthridinium salt Pending JPS56118069A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2251780A JPS56118069A (en) 1980-02-25 1980-02-25 8,9-dihydroxyphenanthridinium salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2251780A JPS56118069A (en) 1980-02-25 1980-02-25 8,9-dihydroxyphenanthridinium salt

Publications (1)

Publication Number Publication Date
JPS56118069A true JPS56118069A (en) 1981-09-16

Family

ID=12084955

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2251780A Pending JPS56118069A (en) 1980-02-25 1980-02-25 8,9-dihydroxyphenanthridinium salt

Country Status (1)

Country Link
JP (1) JPS56118069A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07501499A (en) * 1991-11-27 1995-02-16 ミネソタ・マイニング・アンド・マニュファクチュアリング・カンパニー Method and article for microwave bonding polyethylene pipes
CN103145617A (en) * 2013-03-01 2013-06-12 中国科学院昆明植物研究所 Phenanthridine derivative as well as medicinal composition, preparation method and application thereof
US9682954B2 (en) 2013-03-01 2017-06-20 Kunming Institute Of Botany, The Chinese Academy Of Sciences Phenanthridine derivatives, preparation methods and uses thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07501499A (en) * 1991-11-27 1995-02-16 ミネソタ・マイニング・アンド・マニュファクチュアリング・カンパニー Method and article for microwave bonding polyethylene pipes
CN103145617A (en) * 2013-03-01 2013-06-12 中国科学院昆明植物研究所 Phenanthridine derivative as well as medicinal composition, preparation method and application thereof
US9682954B2 (en) 2013-03-01 2017-06-20 Kunming Institute Of Botany, The Chinese Academy Of Sciences Phenanthridine derivatives, preparation methods and uses thereof

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