JPS56110700A - Estradiol-17alphaderivative and ist antitumor agent - Google Patents
Estradiol-17alphaderivative and ist antitumor agentInfo
- Publication number
- JPS56110700A JPS56110700A JP1463080A JP1463080A JPS56110700A JP S56110700 A JPS56110700 A JP S56110700A JP 1463080 A JP1463080 A JP 1463080A JP 1463080 A JP1463080 A JP 1463080A JP S56110700 A JPS56110700 A JP S56110700A
- Authority
- JP
- Japan
- Prior art keywords
- estradiol
- reacted
- antitumor agent
- ist
- thf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- VOXZDWNPVJITMN-SFFUCWETSA-N 17α-estradiol Chemical group OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-SFFUCWETSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 abstract 1
- 229960004630 chlorambucil Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 e.g. Substances 0.000 abstract 1
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 abstract 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 210000001672 ovary Anatomy 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004673 propylcarbonyl group Chemical group 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1463080A JPS56110700A (en) | 1980-02-08 | 1980-02-08 | Estradiol-17alphaderivative and ist antitumor agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1463080A JPS56110700A (en) | 1980-02-08 | 1980-02-08 | Estradiol-17alphaderivative and ist antitumor agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56110700A true JPS56110700A (en) | 1981-09-01 |
| JPS617439B2 JPS617439B2 (enrdf_load_stackoverflow) | 1986-03-06 |
Family
ID=11866512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1463080A Granted JPS56110700A (en) | 1980-02-08 | 1980-02-08 | Estradiol-17alphaderivative and ist antitumor agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56110700A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6426595A (en) * | 1987-07-22 | 1989-01-27 | Kureha Chemical Ind Co Ltd | Injection containing estradiol derivative |
| EP0573977A3 (en) * | 1992-06-11 | 1996-01-31 | Kureha Chemical Ind Co Ltd | Novel estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62203739U (enrdf_load_stackoverflow) * | 1986-06-18 | 1987-12-25 |
-
1980
- 1980-02-08 JP JP1463080A patent/JPS56110700A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6426595A (en) * | 1987-07-22 | 1989-01-27 | Kureha Chemical Ind Co Ltd | Injection containing estradiol derivative |
| EP0573977A3 (en) * | 1992-06-11 | 1996-01-31 | Kureha Chemical Ind Co Ltd | Novel estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS617439B2 (enrdf_load_stackoverflow) | 1986-03-06 |
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