JPS56104868A - Conversion between polymorphous crystals of cimetidine - Google Patents
Conversion between polymorphous crystals of cimetidineInfo
- Publication number
- JPS56104868A JPS56104868A JP755980A JP755980A JPS56104868A JP S56104868 A JPS56104868 A JP S56104868A JP 755980 A JP755980 A JP 755980A JP 755980 A JP755980 A JP 755980A JP S56104868 A JPS56104868 A JP S56104868A
- Authority
- JP
- Japan
- Prior art keywords
- cimetidine
- solution
- dissolved
- cooled
- polymorphous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 title abstract 8
- 229960001380 cimetidine Drugs 0.000 title abstract 8
- 239000013078 crystal Substances 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 title 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 6
- 239000000243 solution Substances 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- 239000003929 acidic solution Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP755980A JPS56104868A (en) | 1980-01-24 | 1980-01-24 | Conversion between polymorphous crystals of cimetidine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP755980A JPS56104868A (en) | 1980-01-24 | 1980-01-24 | Conversion between polymorphous crystals of cimetidine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56104868A true JPS56104868A (en) | 1981-08-20 |
JPH0149706B2 JPH0149706B2 (enrdf_load_stackoverflow) | 1989-10-25 |
Family
ID=11669156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP755980A Granted JPS56104868A (en) | 1980-01-24 | 1980-01-24 | Conversion between polymorphous crystals of cimetidine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56104868A (enrdf_load_stackoverflow) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5867676A (ja) * | 1981-09-25 | 1983-04-22 | リヒテル・ゲデオン・ベギエスゼテイ・ギヤル・ア−ル・テイ− | シメチジンの新しい結晶変異体およびその製造方法 |
US4786735A (en) * | 1986-08-01 | 1988-11-22 | Smithkline Beckman Corporation | Process for preparing cimetidine polymorph B |
JPH01121270A (ja) * | 1987-11-04 | 1989-05-12 | Mitsui Petrochem Ind Ltd | N−シアノ−n’−メチル−n’’−[2−{(5−メチル−1h−イミダゾール−4−イル)メチルチオ}エチル]グアニジンの精製法 |
US4996222A (en) * | 1986-08-01 | 1991-02-26 | Smith Kline & French Laboratories Limited | Pharmaceutical formulations |
US5808090A (en) * | 1996-02-22 | 1998-09-15 | Endo Pharmaceuticals Inc. | Process for preventing precipitation in cimetidine injection solutions |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5340771A (en) * | 1976-09-21 | 1978-04-13 | Smith Kline French Lab | Novel polymorph of heterocyclic compound |
-
1980
- 1980-01-24 JP JP755980A patent/JPS56104868A/ja active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5340771A (en) * | 1976-09-21 | 1978-04-13 | Smith Kline French Lab | Novel polymorph of heterocyclic compound |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5867676A (ja) * | 1981-09-25 | 1983-04-22 | リヒテル・ゲデオン・ベギエスゼテイ・ギヤル・ア−ル・テイ− | シメチジンの新しい結晶変異体およびその製造方法 |
US4786735A (en) * | 1986-08-01 | 1988-11-22 | Smithkline Beckman Corporation | Process for preparing cimetidine polymorph B |
US4996222A (en) * | 1986-08-01 | 1991-02-26 | Smith Kline & French Laboratories Limited | Pharmaceutical formulations |
JPH0643304B2 (ja) * | 1986-08-01 | 1994-06-08 | スミス・クライン・アンド・フレンチ・ラボラトリース・リミテッド | 製剤処方 |
JPH01121270A (ja) * | 1987-11-04 | 1989-05-12 | Mitsui Petrochem Ind Ltd | N−シアノ−n’−メチル−n’’−[2−{(5−メチル−1h−イミダゾール−4−イル)メチルチオ}エチル]グアニジンの精製法 |
US5808090A (en) * | 1996-02-22 | 1998-09-15 | Endo Pharmaceuticals Inc. | Process for preventing precipitation in cimetidine injection solutions |
Also Published As
Publication number | Publication date |
---|---|
JPH0149706B2 (enrdf_load_stackoverflow) | 1989-10-25 |
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