JPS56104866A - Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt - Google Patents
Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate saltInfo
- Publication number
- JPS56104866A JPS56104866A JP705880A JP705880A JPS56104866A JP S56104866 A JPS56104866 A JP S56104866A JP 705880 A JP705880 A JP 705880A JP 705880 A JP705880 A JP 705880A JP S56104866 A JPS56104866 A JP S56104866A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- acid
- tartaric acid
- piperidinecarboxylic acid
- released
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 title abstract 6
- 239000003146 anticoagulant agent Substances 0.000 abstract 2
- 229940127219 anticoagulant drug Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP705880A JPS56104866A (en) | 1980-01-24 | 1980-01-24 | Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP705880A JPS56104866A (en) | 1980-01-24 | 1980-01-24 | Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56104866A true JPS56104866A (en) | 1981-08-20 |
| JPS6234035B2 JPS6234035B2 (enExample) | 1987-07-24 |
Family
ID=11655459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP705880A Granted JPS56104866A (en) | 1980-01-24 | 1980-01-24 | Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56104866A (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02212473A (ja) * | 1989-02-13 | 1990-08-23 | Mitsubishi Kasei Corp | （２ｒ．４ｒ）−４−メチル−２−ピペリジンカルボン酸エチルエステルのｌ−酒石酸塩ならびに（２ｒ．４ｒ）−４−メチル−２−ピペリジンカルボン酸エチルエステルのｌ−酒石酸塩およびその脱塩体の製造法 |
| JP2008247922A (ja) * | 1995-06-30 | 2008-10-16 | Astrazeneca Ab | エナンチオマーとして純粋なアゼチジン−２−カルボン酸の製造方法 |
| JP2009120611A (ja) * | 1996-04-26 | 2009-06-04 | Astrazeneca Ab | エナンチオマーとして純粋なアゼチジン−２−カルボン酸の改良された製造方法 |
| US20140088310A1 (en) * | 2011-04-04 | 2014-03-27 | Lundbeck Pharmaceuticals Italy S.P.A. | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate |
-
1980
- 1980-01-24 JP JP705880A patent/JPS56104866A/ja active Granted
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02212473A (ja) * | 1989-02-13 | 1990-08-23 | Mitsubishi Kasei Corp | （２ｒ．４ｒ）−４−メチル−２−ピペリジンカルボン酸エチルエステルのｌ−酒石酸塩ならびに（２ｒ．４ｒ）−４−メチル−２−ピペリジンカルボン酸エチルエステルのｌ−酒石酸塩およびその脱塩体の製造法 |
| JP2008247922A (ja) * | 1995-06-30 | 2008-10-16 | Astrazeneca Ab | エナンチオマーとして純粋なアゼチジン−２−カルボン酸の製造方法 |
| JP2009120611A (ja) * | 1996-04-26 | 2009-06-04 | Astrazeneca Ab | エナンチオマーとして純粋なアゼチジン−２−カルボン酸の改良された製造方法 |
| US20140088310A1 (en) * | 2011-04-04 | 2014-03-27 | Lundbeck Pharmaceuticals Italy S.P.A. | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate |
| JP2014510117A (ja) * | 2011-04-04 | 2014-04-24 | ルンドベック ファーマシューティカルズ イタリー ソシエタ ペル アチオニ | アルガトロバン一水和物合成のためのプロセス中間体の製造方法 |
| JP2017186350A (ja) * | 2011-04-04 | 2017-10-12 | ルンドベック ファーマシューティカルズ イタリー ソシエタ ペル アチオニ | アルガトロバン一水和物合成のためのプロセス中間体の製造方法 |
| US9994526B2 (en) | 2011-04-04 | 2018-06-12 | Lundbeck Pharmaceuticals Italy S.P.A. | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate |
| US10385020B2 (en) | 2011-04-04 | 2019-08-20 | Lundbeck Pharmaceuticals Italy S.P.A. | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6234035B2 (enExample) | 1987-07-24 |
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