JPS5599197A

JPS5599197A - Preparation of colistin heptapeptide

Preparation of colistin heptapeptide

Info

Publication number: JPS5599197A
Authority: JP; Japan
Prior art keywords: colistin; heptapeptide; proteinase; preparation; hydrolyzing
Prior art date: 1979-01-23
Legal status : Granted

Application number

JP669779A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6216640B2 (enrdf_load_stackoverflow

Inventor

Mikiko Kagawa

Yasuo Koyama

Current Assignee

KAYAKU KK

Original Assignee

KAYAKU KK

Priority date

1979-01-23

Filing date

1979-01-23

Publication date

1980-07-28

1979-01-23 Application filed by KAYAKU KK filed Critical KAYAKU KK

1979-01-23 Priority to JP669779A priority Critical patent/JPS5599197A/ja

1980-07-28 Publication of JPS5599197A publication Critical patent/JPS5599197A/ja

1987-04-14 Publication of JPS6216640B2 publication Critical patent/JPS6216640B2/ja

Status Granted legal-status Critical Current

Links

HCSATRDQWBMHRF-UHFFFAOYSA-N 21-amino-6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptone Chemical compound CC(C)CC1NC(=O)C(CCN)NC(=O)C(N)CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC1=O HCSATRDQWBMHRF-UHFFFAOYSA-N 0.000 title abstract 3
108010028288 colistin heptapeptide Proteins 0.000 title abstract 3
108010078777 Colistin Proteins 0.000 abstract 5
229960003346 colistin Drugs 0.000 abstract 5
JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 abstract 5
XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 abstract 5
KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 abstract 5
102000035195 Peptidases Human genes 0.000 abstract 3
108091005804 Peptidases Proteins 0.000 abstract 3
235000019833 protease Nutrition 0.000 abstract 3
SXGMVGOVILIERA-UHFFFAOYSA-N 2,3-diaminobutanoic acid Chemical group CC(N)C(N)C(O)=O SXGMVGOVILIERA-UHFFFAOYSA-N 0.000 abstract 2
230000003301 hydrolyzing effect Effects 0.000 abstract 2
241000193830 Bacillus <bacterium> Species 0.000 abstract 1
241000894006 Bacteria Species 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
238000001228 spectrum Methods 0.000 abstract 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1