JPS5599197A - Preparation of colistin heptapeptide - Google Patents

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Publication number

JPS5599197A

JPS5599197A JP669779A JP669779A JPS5599197A JP S5599197 A JPS5599197 A JP S5599197A JP 669779 A JP669779 A JP 669779A JP 669779 A JP669779 A JP 669779A JP S5599197 A JPS5599197 A JP S5599197A

Authority

JP

Japan

Prior art keywords

colistin

heptapeptide

proteinase

preparation

hydrolyzing

Prior art date

1979-01-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• HCSATRDQWBMHRF-UHFFFAOYSA-N 21-amino-6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptone Chemical compound CC(C)CC1NC(=O)C(CCN)NC(=O)C(N)CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC1=O HCSATRDQWBMHRF-UHFFFAOYSA-N 0.000 title abstract 3
• 108010028288 colistin heptapeptide Proteins 0.000 title abstract 3
• 108010078777 Colistin Proteins 0.000 abstract 5
• 229960003346 colistin Drugs 0.000 abstract 5
• JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 abstract 5
• XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 abstract 5
• KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 abstract 5
• 102000035195 Peptidases Human genes 0.000 abstract 3
• 108091005804 Peptidases Proteins 0.000 abstract 3
• 235000019833 protease Nutrition 0.000 abstract 3
• SXGMVGOVILIERA-UHFFFAOYSA-N 2,3-diaminobutanoic acid Chemical group CC(N)C(N)C(O)=O SXGMVGOVILIERA-UHFFFAOYSA-N 0.000 abstract 2
• 230000003301 hydrolyzing effect Effects 0.000 abstract 2
• 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
• 241000894006 Bacteria Species 0.000 abstract 1
• 102000004190 Enzymes Human genes 0.000 abstract 1
• 108090000790 Enzymes Proteins 0.000 abstract 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
• 239000004473 Threonine Substances 0.000 abstract 1
• 230000000844 anti-bacterial effect Effects 0.000 abstract 1
• 125000004122 cyclic group Chemical group 0.000 abstract 1
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
• 238000001228 spectrum Methods 0.000 abstract 1
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1

Cited By (3)