JPS5585578A - Prostaglandin i2 derivative - Google Patents
Prostaglandin i2 derivativeInfo
- Publication number
- JPS5585578A JPS5585578A JP15758978A JP15758978A JPS5585578A JP S5585578 A JPS5585578 A JP S5585578A JP 15758978 A JP15758978 A JP 15758978A JP 15758978 A JP15758978 A JP 15758978A JP S5585578 A JPS5585578 A JP S5585578A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pgi2
- prostaglandin
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Prostaglandin I2 derivatives of formula VI[R is -OCH2COOC2H5, -OCH(CH3)COOC2H5, -OCH2CH2OCH3, -(OCH2CH2)3OH, phthalidoxy, -OC H2CH2N(CH2CH2OH)2, 2-(2-pyridyl)ethocy, 2-(6-hydroxypyridyl)methoxy, N- cyclohexylamide, N,N'-dicyclohexylureide]. EXAMPLE:PGI2 methoxyethyl ester. USE:Hypotensor and antithrombosis; the products sustain the equal or superior pharmaceutical activities to those of PGI2 and remove the structural instability under neutral and acidic conditions, thus permitting oral administration. PREPARATION:The compound of formula III is esterified or amidated and the resulting compound is cyclized intramolecularly. The product of formula V is subjected to dehydroiodization to give the objective compound of formula VI.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15758978A JPS5585578A (en) | 1978-12-22 | 1978-12-22 | Prostaglandin i2 derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15758978A JPS5585578A (en) | 1978-12-22 | 1978-12-22 | Prostaglandin i2 derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5585578A true JPS5585578A (en) | 1980-06-27 |
JPS6215551B2 JPS6215551B2 (en) | 1987-04-08 |
Family
ID=15653000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15758978A Granted JPS5585578A (en) | 1978-12-22 | 1978-12-22 | Prostaglandin i2 derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5585578A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6013779A (en) * | 1983-07-05 | 1985-01-24 | Green Cross Corp:The | Prostaglandin i2 derivative |
JP2013231038A (en) * | 2013-06-04 | 2013-11-14 | Techfields Biochem Co Ltd | Positively charged water-soluble prodrug of prostaglandin and related compound having very high skin-penetration rate |
JP2015134801A (en) * | 2015-03-09 | 2015-07-27 | テックフィールズ バイオケム カンパニー リミテッド | Prostaglandin and positively charged water-soluble prodrug of related compound having very high skin penetration rate |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5446773A (en) * | 1977-09-22 | 1979-04-12 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog and its preparation |
-
1978
- 1978-12-22 JP JP15758978A patent/JPS5585578A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5446773A (en) * | 1977-09-22 | 1979-04-12 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog and its preparation |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6013779A (en) * | 1983-07-05 | 1985-01-24 | Green Cross Corp:The | Prostaglandin i2 derivative |
US4613614A (en) * | 1983-07-05 | 1986-09-23 | The Green Cross Corporation | Prostaglandin I2 ester and fat emulsion containing the same |
JPH042595B2 (en) * | 1983-07-05 | 1992-01-20 | ||
JP2013231038A (en) * | 2013-06-04 | 2013-11-14 | Techfields Biochem Co Ltd | Positively charged water-soluble prodrug of prostaglandin and related compound having very high skin-penetration rate |
JP2015134801A (en) * | 2015-03-09 | 2015-07-27 | テックフィールズ バイオケム カンパニー リミテッド | Prostaglandin and positively charged water-soluble prodrug of related compound having very high skin penetration rate |
Also Published As
Publication number | Publication date |
---|---|
JPS6215551B2 (en) | 1987-04-08 |
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