JPS5576857A - 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation - Google Patents
24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparationInfo
- Publication number
- JPS5576857A JPS5576857A JP14902978A JP14902978A JPS5576857A JP S5576857 A JPS5576857 A JP S5576857A JP 14902978 A JP14902978 A JP 14902978A JP 14902978 A JP14902978 A JP 14902978A JP S5576857 A JPS5576857 A JP S5576857A
- Authority
- JP
- Japan
- Prior art keywords
- difluoro
- pref
- protected derivative
- hydroxyvitamin
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LRNVEDCUBISUTC-OWRPZGOZSA-N 24,24-difluoro-25-hydroxyvitamin D3 Chemical compound C1(/[C@@H]2CCC([C@]2(CCC1)C)[C@@H](CCC(F)(F)C(C)(C)O)C)=C\C=C1\C[C@H](O)CCC1=C LRNVEDCUBISUTC-OWRPZGOZSA-N 0.000 title 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 238000010521 absorption reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ULFGCRUVFLNQSM-UGJHKWMDSA-N (6r)-6-[(9s,10r,13r,14r,17r)-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-3,3-difluoro-2-methylheptan-2-ol Chemical compound C1CCC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H](CCC(F)(F)C(C)(C)O)C)CC[C@H]33)C)C3=CC=C21 ULFGCRUVFLNQSM-UGJHKWMDSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 230000001678 irradiating effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14902978A JPS5576857A (en) | 1978-12-04 | 1978-12-04 | 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14902978A JPS5576857A (en) | 1978-12-04 | 1978-12-04 | 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5576857A true JPS5576857A (en) | 1980-06-10 |
| JPS6148498B2 JPS6148498B2 (en, 2012) | 1986-10-24 |
Family
ID=15466105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14902978A Granted JPS5576857A (en) | 1978-12-04 | 1978-12-04 | 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5576857A (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868165A (en) * | 1985-05-30 | 1989-09-19 | Taisho Pharmaceutical Co., Ltd. | 24,24-difluoro-26,27-dimethylvitamin D3 derivatives |
-
1978
- 1978-12-04 JP JP14902978A patent/JPS5576857A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868165A (en) * | 1985-05-30 | 1989-09-19 | Taisho Pharmaceutical Co., Ltd. | 24,24-difluoro-26,27-dimethylvitamin D3 derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6148498B2 (en, 2012) | 1986-10-24 |
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