JPS5564556A - Novel thyroliberine derivative - Google Patents

Novel thyroliberine derivative

Info

Publication number
JPS5564556A
JPS5564556A JP13653978A JP13653978A JPS5564556A JP S5564556 A JPS5564556 A JP S5564556A JP 13653978 A JP13653978 A JP 13653978A JP 13653978 A JP13653978 A JP 13653978A JP S5564556 A JPS5564556 A JP S5564556A
Authority
JP
Japan
Prior art keywords
thyroliberine
amino
protecting group
derivative
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13653978A
Other languages
Japanese (ja)
Other versions
JPS5931496B2 (en
Inventor
Masaru Shiraki
Tomokuni Kokubu
Shinji Sawano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Original Assignee
Agency of Industrial Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency of Industrial Science and Technology filed Critical Agency of Industrial Science and Technology
Priority to JP53136539A priority Critical patent/JPS5931496B2/en
Publication of JPS5564556A publication Critical patent/JPS5564556A/en
Publication of JPS5931496B2 publication Critical patent/JPS5931496B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A thyroliberine derivative and its salt of formula (PCA-His-Pro is pyroglutamyl-hystidylprolyl; X is OH or amino; m is 2W5; n is 1W2).
EXAMPLE: ε-Thyroliberylaminocaproic acid.
USE: An intermediate of a polymer having thyroliberine residue effective to accelerate the secretion of thyrotropic hormones.
PROCESS: ε-Aminocaproic acid benzyl p-toluenesulfonic acid salt is reacted with N- benzyloxycarbonylproline in the presence of a water-soluble carbodiimide, and the reaction product is amidated simultaneously with the elimination of carboxyl-protecting group. The amino-protecting group of the resulting compound is eliminated by hydrogenation. The product is condensed, and hydrogenated to eliminate the amino-protecting group, to obtain the objective compound of formula wherein X is amine.
COPYRIGHT: (C)1980,JPO&Japio
JP53136539A 1978-11-06 1978-11-06 Novel tyroliverine derivative Expired JPS5931496B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53136539A JPS5931496B2 (en) 1978-11-06 1978-11-06 Novel tyroliverine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53136539A JPS5931496B2 (en) 1978-11-06 1978-11-06 Novel tyroliverine derivative

Publications (2)

Publication Number Publication Date
JPS5564556A true JPS5564556A (en) 1980-05-15
JPS5931496B2 JPS5931496B2 (en) 1984-08-02

Family

ID=15177547

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53136539A Expired JPS5931496B2 (en) 1978-11-06 1978-11-06 Novel tyroliverine derivative

Country Status (1)

Country Link
JP (1) JPS5931496B2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60244279A (en) * 1984-05-21 1985-12-04 Mitsubishi Electric Corp Automatic inspection system for microorganism, or the like
JPH01121754A (en) * 1987-11-06 1989-05-15 Ebara Infilco Co Ltd Automatic observation device for microorganism in liquid

Also Published As

Publication number Publication date
JPS5931496B2 (en) 1984-08-02

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