JPS5564556A - Novel thyroliberine derivative - Google Patents
Novel thyroliberine derivativeInfo
- Publication number
- JPS5564556A JPS5564556A JP13653978A JP13653978A JPS5564556A JP S5564556 A JPS5564556 A JP S5564556A JP 13653978 A JP13653978 A JP 13653978A JP 13653978 A JP13653978 A JP 13653978A JP S5564556 A JPS5564556 A JP S5564556A
- Authority
- JP
- Japan
- Prior art keywords
- thyroliberine
- amino
- protecting group
- derivative
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:A thyroliberine derivative and its salt of formula (PCA-His-Pro is pyroglutamyl-hystidylprolyl; X is OH or amino; m is 2W5; n is 1W2).
EXAMPLE: ε-Thyroliberylaminocaproic acid.
USE: An intermediate of a polymer having thyroliberine residue effective to accelerate the secretion of thyrotropic hormones.
PROCESS: ε-Aminocaproic acid benzyl p-toluenesulfonic acid salt is reacted with N- benzyloxycarbonylproline in the presence of a water-soluble carbodiimide, and the reaction product is amidated simultaneously with the elimination of carboxyl-protecting group. The amino-protecting group of the resulting compound is eliminated by hydrogenation. The product is condensed, and hydrogenated to eliminate the amino-protecting group, to obtain the objective compound of formula wherein X is amine.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53136539A JPS5931496B2 (en) | 1978-11-06 | 1978-11-06 | Novel tyroliverine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53136539A JPS5931496B2 (en) | 1978-11-06 | 1978-11-06 | Novel tyroliverine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5564556A true JPS5564556A (en) | 1980-05-15 |
JPS5931496B2 JPS5931496B2 (en) | 1984-08-02 |
Family
ID=15177547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53136539A Expired JPS5931496B2 (en) | 1978-11-06 | 1978-11-06 | Novel tyroliverine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5931496B2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60244279A (en) * | 1984-05-21 | 1985-12-04 | Mitsubishi Electric Corp | Automatic inspection system for microorganism, or the like |
JPH01121754A (en) * | 1987-11-06 | 1989-05-15 | Ebara Infilco Co Ltd | Automatic observation device for microorganism in liquid |
-
1978
- 1978-11-06 JP JP53136539A patent/JPS5931496B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5931496B2 (en) | 1984-08-02 |
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