JPS5543024A - Dl-threo-2,3-dihydroxy-4-phenylbutanoic acid derivative - Google Patents
Dl-threo-2,3-dihydroxy-4-phenylbutanoic acid derivativeInfo
- Publication number
- JPS5543024A JPS5543024A JP11598978A JP11598978A JPS5543024A JP S5543024 A JPS5543024 A JP S5543024A JP 11598978 A JP11598978 A JP 11598978A JP 11598978 A JP11598978 A JP 11598978A JP S5543024 A JPS5543024 A JP S5543024A
- Authority
- JP
- Japan
- Prior art keywords
- threo
- dihydroxy
- acid derivative
- formula
- mole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A DL-threo-2,3-dihydroxy-4-butanoic acid derivative of formula I: (R is ester residue).
EXAMPLE: Methyl DL-threo-2,3-dihydroxy-4-phenyl butanoate.
USE: An intermediate for the synthesis of Bestatin having a strong inhibitory action on aminopeptidase B, Leucine aminopeptidase and bleomycin hydrolase.
PROCESS: One mole of a trans-4-phenyl-2-butenoic acid derivative of formula II is converted into a cis-glycol, preferably in the presence of a solvent and about 0.01W 0.001 mole of osmium tetroxide and about 1.5W2.5 moles of an oxidizing agent, e.g. barium chlorate or hydrogen peroxide, to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11598978A JPS6033377B2 (en) | 1978-09-22 | 1978-09-22 | DL-threo-2,3-dihydroxy-4-phenylbutanoic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11598978A JPS6033377B2 (en) | 1978-09-22 | 1978-09-22 | DL-threo-2,3-dihydroxy-4-phenylbutanoic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5543024A true JPS5543024A (en) | 1980-03-26 |
JPS6033377B2 JPS6033377B2 (en) | 1985-08-02 |
Family
ID=14676103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11598978A Expired JPS6033377B2 (en) | 1978-09-22 | 1978-09-22 | DL-threo-2,3-dihydroxy-4-phenylbutanoic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6033377B2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0621072U (en) * | 1992-06-04 | 1994-03-18 | 株式会社呉竹精昇堂 | Hanging mount |
-
1978
- 1978-09-22 JP JP11598978A patent/JPS6033377B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6033377B2 (en) | 1985-08-02 |
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