JPS5540615A - Separation and purification of cephalosporins - Google Patents
Separation and purification of cephalosporinsInfo
- Publication number
- JPS5540615A JPS5540615A JP11309678A JP11309678A JPS5540615A JP S5540615 A JPS5540615 A JP S5540615A JP 11309678 A JP11309678 A JP 11309678A JP 11309678 A JP11309678 A JP 11309678A JP S5540615 A JPS5540615 A JP S5540615A
- Authority
- JP
- Japan
- Prior art keywords
- cpc
- cephalosporin
- organic solvent
- separation
- adsorbed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 abstract 6
- SUBPBOVIYZLZKW-SSDOTTSWSA-N (2r)-4-(3-carboxypropyl)piperazine-2-carboxylic acid Chemical compound OC(=O)CCCN1CCN[C@@H](C(O)=O)C1 SUBPBOVIYZLZKW-SSDOTTSWSA-N 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 2
- 229940124587 cephalosporin Drugs 0.000 abstract 2
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- XWCFYHBHOFBVIV-UHFFFAOYSA-N Deacetylcephalosporin C Natural products S1CC(CO)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C21 XWCFYHBHOFBVIV-UHFFFAOYSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- NNQIJOYQWYKBOW-JWKOBGCHSA-N deacetoxycephalosporin C Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 NNQIJOYQWYKBOW-JWKOBGCHSA-N 0.000 abstract 1
- XWCFYHBHOFBVIV-JWKOBGCHSA-N deacetylcephalosporin C Chemical compound S1CC(CO)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@H]21 XWCFYHBHOFBVIV-JWKOBGCHSA-N 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11309678A JPS5540615A (en) | 1978-09-14 | 1978-09-14 | Separation and purification of cephalosporins |
| DE7979301861T DE2964213D1 (en) | 1978-09-14 | 1979-09-11 | Method of separating cephalosporins |
| EP79301861A EP0009363B1 (en) | 1978-09-14 | 1979-09-11 | Method of separating cephalosporins |
| ES484144A ES484144A1 (es) | 1978-09-14 | 1979-09-13 | Un metodo para separar entre si desacetil-cefalosporina c, desacetoxi-cefalosporina c y cefalosporina c |
| US06/522,549 US4535155A (en) | 1978-09-14 | 1983-08-11 | Method for separating cephalosporins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11309678A JPS5540615A (en) | 1978-09-14 | 1978-09-14 | Separation and purification of cephalosporins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5540615A true JPS5540615A (en) | 1980-03-22 |
| JPS6149317B2 JPS6149317B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1986-10-29 |
Family
ID=14603368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11309678A Granted JPS5540615A (en) | 1978-09-14 | 1978-09-14 | Separation and purification of cephalosporins |
Country Status (5)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10870721B2 (en) | 2013-06-18 | 2020-12-22 | Panasonic Intellectual Property Management Co., Ltd. | Polyphenylene ether resin composition, prepreg, metal-clad laminate and printed wiring board |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2042383B1 (es) * | 1991-12-17 | 1994-07-01 | Univ Madrid Complutense | Procedimiento de purificacion de cefalosporina c por adsorcion con resinas funcionalizadas tipo divinilbenceno estireno. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3709880A (en) * | 1970-12-09 | 1973-01-09 | Merck & Co Inc | Antibiotic purification process |
| JPS5230594B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-03-02 | 1977-08-09 | ||
| SE425254B (sv) * | 1973-06-16 | 1982-09-13 | Takeda Chemical Industries Ltd | Sett att framstella deacetoxiefalosporin c genom odling av vissa organismer, i nagra fall pa medier med visst aminosyrainnehall |
| US3983108A (en) * | 1975-02-10 | 1976-09-28 | Merck & Co., Inc. | Antibiotic purification process |
-
1978
- 1978-09-14 JP JP11309678A patent/JPS5540615A/ja active Granted
-
1979
- 1979-09-11 DE DE7979301861T patent/DE2964213D1/de not_active Expired
- 1979-09-11 EP EP79301861A patent/EP0009363B1/en not_active Expired
- 1979-09-13 ES ES484144A patent/ES484144A1/es not_active Expired
-
1983
- 1983-08-11 US US06/522,549 patent/US4535155A/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10870721B2 (en) | 2013-06-18 | 2020-12-22 | Panasonic Intellectual Property Management Co., Ltd. | Polyphenylene ether resin composition, prepreg, metal-clad laminate and printed wiring board |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0009363A1 (en) | 1980-04-02 |
| JPS6149317B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1986-10-29 |
| DE2964213D1 (en) | 1983-01-13 |
| ES484144A1 (es) | 1980-04-16 |
| EP0009363B1 (en) | 1982-12-08 |
| US4535155A (en) | 1985-08-13 |
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