JPS5540612A - 3"-acetyl-4"-isovaleryltylosin - Google Patents
3"-acetyl-4"-isovaleryltylosinInfo
- Publication number
- JPS5540612A JPS5540612A JP11302378A JP11302378A JPS5540612A JP S5540612 A JPS5540612 A JP S5540612A JP 11302378 A JP11302378 A JP 11302378A JP 11302378 A JP11302378 A JP 11302378A JP S5540612 A JPS5540612 A JP S5540612A
- Authority
- JP
- Japan
- Prior art keywords
- acetyl
- formula
- tylosin
- methanol
- isovaleryltylosin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:3"-Acetyl-4"-isovaleryltylosin of formula I (Ac=acetyl; Iva= isovaleryl) or its pharmaceutically permissible salts.
USE: Antibiotics. Pharmaceuticals for veterinary use, additives of feed. Same antibacterial activity as the antibiotic, tylosin, and strong antibacterial property against A, B and C types of macrolide-resistant bacteria. Free from bitter taste, and preferable as syrup for infants.
PROCESS: Tylosin is made to react with acetic anhydride in the presence of an inorganic base to give a compound of formula II, which is then heated to be acylated with isovaleric anhydride in an inert organic solvent in the presence of a tertiary organic amine. The product obtained is treated with NH3 in methanol or thanol, and then subjected to thermal treatment in methanol which may contain water to remove the acetyl of 2' position, giving the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11302378A JPS5540612A (en) | 1978-09-14 | 1978-09-14 | 3"-acetyl-4"-isovaleryltylosin |
SE7907547A SE445739B (en) | 1978-09-14 | 1979-09-11 | 3 ", 4" DIACYLTYLOSINE DERIVATIVE |
FR7922759A FR2436150A1 (en) | 1978-09-14 | 1979-09-12 | 3 '', 4 '' DERIVATIVES - DIACYLTYLOSINE USEFUL AS MEDICINES |
IT25677/79A IT1123137B (en) | 1978-09-14 | 1979-09-12 | "3", 4 "-DIACYLTYLOSINE AND PROCEDURE FOR ITS PRODUCTION |
CA335,557A CA1133899A (en) | 1978-09-14 | 1979-09-13 | 3", 4"-diacyltylosin derivatives |
GB7931717A GB2031418B (en) | 1978-09-14 | 1979-09-13 | 3'',4''-diacyl derivatives of tylosin |
CH830879A CH642381A5 (en) | 1978-09-14 | 1979-09-13 | DIALKANOYLTYLOSIN DERIVATIVES. |
HU79TO1116A HU181976B (en) | 1978-09-14 | 1979-09-13 | Process for preparing 3",4"-diacyl-tylosin derivatives |
DK382979A DK153492C (en) | 1978-09-14 | 1979-09-13 | PROCEDURE FOR PREPARING 3AE, 4AE-DIACYLTYLOSIN DERIVATIVES |
NL7906894A NL7906894A (en) | 1978-09-14 | 1979-09-14 | 3 ", 4" DIACYLTYLOSINE DERIVATIVES. |
US06/075,661 US4268665A (en) | 1978-09-14 | 1979-09-14 | Derivatives of antibiotic tylosin |
DE19792937267 DE2937267A1 (en) | 1978-09-14 | 1979-09-14 | 3 '', 4 '' DIACYLTYLOSIN DERIVATIVES |
AT0607479A AT366699B (en) | 1978-09-14 | 1979-09-14 | METHOD FOR PRODUCING 3 '', 4 '' DIACYLTYLOSIN DERIVATIVES |
AT0518080A AT367432B (en) | 1978-09-14 | 1980-10-20 | METHOD FOR PRODUCING NEW 3 ", 4" DIACYLTYLOSIN DERIVATIVES |
DK446985A DK156071C (en) | 1978-09-14 | 1985-10-02 | PROCEDURE FOR PREPARING 3,3 '', 4 '' - TRIACYLTYLOSIN DERIVATIVES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11302378A JPS5540612A (en) | 1978-09-14 | 1978-09-14 | 3"-acetyl-4"-isovaleryltylosin |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5540612A true JPS5540612A (en) | 1980-03-22 |
JPS6155517B2 JPS6155517B2 (en) | 1986-11-28 |
Family
ID=14601497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11302378A Granted JPS5540612A (en) | 1978-09-14 | 1978-09-14 | 3"-acetyl-4"-isovaleryltylosin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5540612A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0375315U (en) * | 1989-11-28 | 1991-07-29 |
-
1978
- 1978-09-14 JP JP11302378A patent/JPS5540612A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6155517B2 (en) | 1986-11-28 |
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