JPS5538304A - Cephalosporin derivative and its preparation - Google Patents

Cephalosporin derivative and its preparation

Info

Publication number
JPS5538304A
JPS5538304A JP11062778A JP11062778A JPS5538304A JP S5538304 A JPS5538304 A JP S5538304A JP 11062778 A JP11062778 A JP 11062778A JP 11062778 A JP11062778 A JP 11062778A JP S5538304 A JPS5538304 A JP S5538304A
Authority
JP
Japan
Prior art keywords
cephalosporin derivative
salt
preparation
lower alkoxy
conuerted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11062778A
Other languages
Japanese (ja)
Inventor
Nobuhiro Oi
Bunya Aoki
Teizo Shinozaki
Kanji Moro
Isao Matsunaga
Takao Nofuji
Toshiyuki Nehashi
Yusuke Aoki
Hisao Endo
Takao Kimura
Hiroshi Okazaki
Haruki Ogawa
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP11062778A priority Critical patent/JPS5538304A/en
Priority to DK225179A priority patent/DK225179A/en
Priority to AU47695/79A priority patent/AU524816B2/en
Priority to GB7919441A priority patent/GB2025944B/en
Priority to IL57480A priority patent/IL57480A/en
Priority to US06/047,781 priority patent/US4298605A/en
Priority to CA329,615A priority patent/CA1131617A/en
Priority to IT68273/79A priority patent/IT1192777B/en
Priority to NO792036A priority patent/NO792036L/en
Priority to CS794208A priority patent/CS212222B2/en
Priority to BE2/57893A priority patent/BE877139A/en
Priority to FI791991A priority patent/FI791991A/en
Priority to SE7905520A priority patent/SE7905520L/en
Priority to HU79CU164A priority patent/HU178461B/en
Priority to PT69794A priority patent/PT69794A/en
Priority to NL7904846A priority patent/NL7904846A/en
Priority to DD79213817A priority patent/DD144412A5/en
Priority to SU792781601A priority patent/SU1118289A3/en
Priority to YU01477/79A priority patent/YU147779A/en
Priority to FR7916089A priority patent/FR2429220A1/en
Priority to ES481837A priority patent/ES481837A1/en
Priority to AT0440879A priority patent/AT365196B/en
Priority to CH588179A priority patent/CH640859A5/en
Priority to DE2925302A priority patent/DE2925302C2/en
Priority to AR277005A priority patent/AR231449A1/en
Priority to IE1182/79A priority patent/IE48581B1/en
Priority to ES489647A priority patent/ES8104305A1/en
Priority to ES489645A priority patent/ES8103099A1/en
Priority to ES489646A priority patent/ES8104303A1/en
Priority to ES489648A priority patent/ES8103100A1/en
Publication of JPS5538304A publication Critical patent/JPS5538304A/en
Priority to US06/136,061 priority patent/US4341776A/en
Priority to US06/136,062 priority patent/US4301161A/en
Priority to US06/136,063 priority patent/US4328224A/en
Priority to CS802742A priority patent/CS212226B2/en
Priority to CS802740A priority patent/CS212224B2/en
Priority to CS802739A priority patent/CS212223B2/en
Priority to CS802741A priority patent/CS212225B2/en
Priority to SU803211175A priority patent/SU980626A3/en
Priority to SU803217954A priority patent/SU1138031A3/en
Priority to AT19281A priority patent/AT369007B/en
Priority to AT19181A priority patent/AT369006B/en
Priority to AT115281A priority patent/AT372685B/en
Priority to AT0115181A priority patent/AT371821B/en
Priority to AR28464081A priority patent/AR231295A1/en
Priority to AR28464281A priority patent/AR228592A1/en
Priority to AR284639A priority patent/AR231294A1/en
Priority to SU813301196A priority patent/SU1047392A3/en
Priority to SU823450441A priority patent/SU1119608A3/en
Priority to YU54483A priority patent/YU54483A/en
Priority to YU00543/83A priority patent/YU54383A/en
Priority to YU00545/83A priority patent/YU54583A/en
Priority to YU00546/83A priority patent/YU54683A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A cephalosporin derivative I (R1 is H, lower alkanoyl, etc.; R2 is H, lower alkoxy, etc.; R3 is H or lower alkyl; R4 is H or OH; R5 is H or lower alkoxy; R6 is H or acetoxy; n is 1W3; m is integer of 1Wn; ρm is position of substituent, etc.) or its salt.
EXAMPLE: 7-{D(-)-α-[ 3-( 3,4-dihydroxybenzoyl )-3-methyl-1-ureido]-α-phenylacetamido}-3-acetoxymethyl-3-cephem-4-carboxylic acid.
USE: Anti-bacterial agents. Particularly effective for Pseudomonas and Serratia.
PROCESS: A 7-aminocephalosporin II (Y is H or protective group), etc. is reacted with a substituted ureidophenylacetic acid III, etc., and if necessary, the COOY at e.g. 4-position is conuerted to COOH or its salt to give a compound I.
COPYRIGHT: (C)1980,JPO&Japio
JP11062778A 1978-06-22 1978-09-11 Cephalosporin derivative and its preparation Pending JPS5538304A (en)

Priority Applications (52)

Application Number Priority Date Filing Date Title
JP11062778A JPS5538304A (en) 1978-09-11 1978-09-11 Cephalosporin derivative and its preparation
DK225179A DK225179A (en) 1978-06-22 1979-05-30 PROCEDURE FOR PREPARING CEPHALOSPORINE DERIVATIVES
AU47695/79A AU524816B2 (en) 1978-06-22 1979-06-01 Cephalosporin derivatives
GB7919441A GB2025944B (en) 1978-06-22 1979-06-04 Cephalosporins
IL57480A IL57480A (en) 1978-06-22 1979-06-05 Benzoylureido cephalosporin derivatives,their preparation and antibacterial preparations containing them
US06/047,781 US4298605A (en) 1978-06-22 1979-06-11 Cephalosporin derivatives
CA329,615A CA1131617A (en) 1978-06-22 1979-06-12 Cephalosporin derivatives
IT68273/79A IT1192777B (en) 1978-06-22 1979-06-14 Cephalosporin derivatives
NO792036A NO792036L (en) 1978-06-22 1979-06-19 PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINS
CS794208A CS212222B2 (en) 1978-06-22 1979-06-19 Method of preparation of the 7-(substituted benzoylureido)-phenyl acetamido derivatives of the cephalosporine
BE2/57893A BE877139A (en) 1978-06-22 1979-06-21 CEPHALOSPORIN DERIVATIVES
FI791991A FI791991A (en) 1978-06-22 1979-06-21 KEFALOSPORINDERIVAT
SE7905520A SE7905520L (en) 1978-06-22 1979-06-21 cephalosporin derivatives
HU79CU164A HU178461B (en) 1978-06-22 1979-06-21 Process for producing 7-square bracket-bracket-benzoyl-ureido-bracket closed-phenyl-acetamido-square bracket closed-3-methyl-3-c3pheme-4-carboxylic acids
PT69794A PT69794A (en) 1978-06-22 1979-06-21 Sephalosporin derivatives
NL7904846A NL7904846A (en) 1978-06-22 1979-06-21 CEPHALOSPORIN DERIVATIVE, ITS PREPARATION AND USE IN AN ANTIBACTERIAL PREPARATION.
DD79213817A DD144412A5 (en) 1978-06-22 1979-06-21 PROCESS FOR THE PREPARATION OF CEPHALOSPORIN DERIVATIVES
SU792781601A SU1118289A3 (en) 1978-06-22 1979-06-21 Method of obtaining cephalosporin derivatives
YU01477/79A YU147779A (en) 1978-06-22 1979-06-22 Process for preparing new cephalosporin derivatives
FR7916089A FR2429220A1 (en) 1978-06-22 1979-06-22 CEPHALOSPORIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
ES481837A ES481837A1 (en) 1978-06-22 1979-06-22 Cephalosporin derivatives
AT0440879A AT365196B (en) 1978-06-22 1979-06-22 METHOD FOR PRODUCING NEW CEPHALOSPORINE COMPOUNDS
CH588179A CH640859A5 (en) 1978-06-22 1979-06-22 CEPHALOSPORINE DERIVATIVES.
DE2925302A DE2925302C2 (en) 1978-06-22 1979-06-22 Acylureidocephalosporin derivatives and their use
AR277005A AR231449A1 (en) 1978-06-22 1979-07-22 PROCEDURE FOR THE PREPARATION OF A BENZOIL-UREIDO-ACETAMIDO-CEFEM-CARBOXILICO ACID DERIVATIVE
IE1182/79A IE48581B1 (en) 1978-06-22 1979-08-08 Benzolylureido-phenyl acetamido cephalosporins
ES489647A ES8104305A1 (en) 1978-06-22 1980-03-17 Cephalosporin derivatives
ES489645A ES8103099A1 (en) 1978-06-22 1980-03-17 Cephalosporin derivatives
ES489646A ES8104303A1 (en) 1978-06-22 1980-03-17 Cephalosporin derivatives
ES489648A ES8103100A1 (en) 1978-06-22 1980-03-17 Cephalosporin derivatives
US06/136,061 US4341776A (en) 1978-06-22 1980-03-28 Cephalosporin derivatives
US06/136,062 US4301161A (en) 1978-06-22 1980-03-28 Cephalosporin derivatives
US06/136,063 US4328224A (en) 1978-06-22 1980-03-28 Cephalosporin derivatives
CS802742A CS212226B2 (en) 1978-09-11 1980-04-18 Method of preparation of 7-(substituted benzoylureido)- phenyl-acetoamido derivatives of the cephalosporine
CS802740A CS212224B2 (en) 1978-09-11 1980-04-18 Method of preparation of 7-(substituted benzoylureido) phenylacetamido derivatives of the cephalosporine
CS802739A CS212223B2 (en) 1978-09-11 1980-04-18 Method of preparation of 7-( substituted benzolureido) phenyl-acetamido derivatives of the cephalosporine
CS802741A CS212225B2 (en) 1978-06-22 1980-04-18 Method of preparation of the 7-(substituted benzoylureido)-phenyl-acetamido derivatives of the cephalosporine
SU803211175A SU980626A3 (en) 1978-09-11 1980-12-04 Process for producing derivatives of cephalosporin or their alkali salts
SU803217954A SU1138031A3 (en) 1978-09-11 1980-12-12 Method of obtaining derivatives of cephalosporin
AT19281A AT369007B (en) 1978-09-11 1981-01-19 METHOD FOR PRODUCING NEW CEPHALOSPORINE DERIVATIVES
AT19181A AT369006B (en) 1978-09-11 1981-01-19 METHOD FOR PRODUCING NEW CEPHALOSPORINE DERIVATIVES
AT115281A AT372685B (en) 1978-09-11 1981-03-12 METHOD FOR PRODUCING NEW CEPHALOSPORINE DERIVATIVES
AT0115181A AT371821B (en) 1978-06-22 1981-03-12 METHOD FOR PRODUCING NEW CEPHALOSPORINE DERIVATIVES
AR28464081A AR231295A1 (en) 1978-09-11 1981-03-17 PROCEDURE FOR THE PREPARATION OF A BENZOILUREIDO-ACETAMIDO-CEFEM-CARBOXILICO ACID DERIVATIVE
AR28464281A AR228592A1 (en) 1978-09-11 1981-03-17 PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF AN ACID-BENZOILUREIDO-ACETAMIDO-CEFEM-CARBOXILICO
AR284639A AR231294A1 (en) 1978-06-22 1981-03-17 PROCEDURE FOR THE PREPARATION OF A BENZOIL-UREIDO-ACETAMIDO-CEFEM-CARBOXILICO ACID DERIVATIVE
SU813301196A SU1047392A3 (en) 1978-09-11 1981-06-24 Process for preparing cephalosporin derivatives
SU823450441A SU1119608A3 (en) 1978-09-11 1982-06-15 Method of obtaining cephalosporin derivatives
YU54483A YU54483A (en) 1978-09-11 1983-03-07 Process for obtaining new cephalosporin derivatives
YU00543/83A YU54383A (en) 1978-06-22 1983-03-07 Process for obtaining new cephalosporin derivatives
YU00545/83A YU54583A (en) 1978-06-22 1983-03-07 Process for obtaining new cephalosporin derivatives
YU00546/83A YU54683A (en) 1978-06-22 1983-03-07 Process for obtining new cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11062778A JPS5538304A (en) 1978-09-11 1978-09-11 Cephalosporin derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5538304A true JPS5538304A (en) 1980-03-17

Family

ID=14540557

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11062778A Pending JPS5538304A (en) 1978-06-22 1978-09-11 Cephalosporin derivative and its preparation

Country Status (2)

Country Link
JP (1) JPS5538304A (en)
SU (3) SU1138031A3 (en)

Also Published As

Publication number Publication date
SU1119608A3 (en) 1984-10-15
SU1138031A3 (en) 1985-01-30
SU1047392A3 (en) 1983-10-07

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