JPS5535069A - Tetrapeptide derivative - Google Patents

Tetrapeptide derivative

Info

Publication number
JPS5535069A
JPS5535069A JP10944078A JP10944078A JPS5535069A JP S5535069 A JPS5535069 A JP S5535069A JP 10944078 A JP10944078 A JP 10944078A JP 10944078 A JP10944078 A JP 10944078A JP S5535069 A JPS5535069 A JP S5535069A
Authority
JP
Japan
Prior art keywords
formula
group
compound
tetrapeptide derivative
protecting groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10944078A
Other languages
Japanese (ja)
Inventor
Masahiko Fujino
Susumu Shinagawa
Kiyohisa Kawai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP10944078A priority Critical patent/JPS5535069A/en
Priority to HUTA001518 priority patent/HU182051B/en
Priority to DE7979101282T priority patent/DE2962325D1/en
Priority to EP19790101282 priority patent/EP0005248B1/en
Priority to CA000326646A priority patent/CA1144542A/en
Priority to DK178279A priority patent/DK149064C/en
Publication of JPS5535069A publication Critical patent/JPS5535069A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A tetrapeptide derivative of formula I: (R1 and R2 are H or methyl groups, at least one of them is methyl group; R3 is lower aliphatic acyl group which may be substituted by OH, lower alkoxy, halogen, or oxo group), and its acid addition salts.
EXAMPLE: H-Tyr-(D)-Ala-Gly-Mephe-NH-NH-CO-CH2-CH3.
USE: Analgesics, having sufficient actions even by intravenous and subcutaneous administration, and a remedy for gastrointestinal diseases, e.g. diarrhea, having gastrointestinal propulsion inhibitory actions.
PROCESS: The protecting groups of a compound of formula II: (R3' and R3 are the same, and may have protecting groups; Y1 is protecting group) are eliminated to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP10944078A 1978-05-02 1978-09-05 Tetrapeptide derivative Pending JPS5535069A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP10944078A JPS5535069A (en) 1978-09-05 1978-09-05 Tetrapeptide derivative
HUTA001518 HU182051B (en) 1978-05-02 1979-04-27 Process for preparing tetrapeptide-hydrazyde derivatives
DE7979101282T DE2962325D1 (en) 1978-05-02 1979-04-30 Tetrapeptidehydrazide derivatives and process for their preparation
EP19790101282 EP0005248B1 (en) 1978-05-02 1979-04-30 Tetrapeptidehydrazide derivatives and process for their preparation
CA000326646A CA1144542A (en) 1978-05-02 1979-04-30 Tetrapeptidehydrazide derivatives
DK178279A DK149064C (en) 1978-05-02 1979-05-01 METHOD OF ANALOGUE FOR THE PREPARATION OF ENKEFALIN ANALOGUE TETRAPEPTIDE HYDRAZIDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10944078A JPS5535069A (en) 1978-09-05 1978-09-05 Tetrapeptide derivative

Publications (1)

Publication Number Publication Date
JPS5535069A true JPS5535069A (en) 1980-03-11

Family

ID=14510290

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10944078A Pending JPS5535069A (en) 1978-05-02 1978-09-05 Tetrapeptide derivative

Country Status (1)

Country Link
JP (1) JPS5535069A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS627881A (en) * 1985-07-01 1987-01-14 オリン　コ−ポレ−シヨン Imparting of properties hardly generating cloudiness and oxidation to copper or copper alloy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS627881A (en) * 1985-07-01 1987-01-14 オリン　コ−ポレ−シヨン Imparting of properties hardly generating cloudiness and oxidation to copper or copper alloy

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