JPS5527127A - Preparation of 2-oxohibaol - Google Patents
Preparation of 2-oxohibaolInfo
- Publication number
- JPS5527127A JPS5527127A JP9900178A JP9900178A JPS5527127A JP S5527127 A JPS5527127 A JP S5527127A JP 9900178 A JP9900178 A JP 9900178A JP 9900178 A JP9900178 A JP 9900178A JP S5527127 A JPS5527127 A JP S5527127A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- product
- lithium
- debrominating
- methylating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:2-Oxohibaol of formula I.
USE: An intermediate of a natural tetracyclic compound, hibaol (diterpene). A compound having pharmacological activity.
PROCESS: The objective compound I is pepared in high yield and in a relatively short process, by (1) reducing a compound II with metallic Li in liquid ammonia, (2) oxidizing the product with hydrogen peroxide to the compound III, (3) reacting the compound III with p-toluenesulfonylhydrazine, (4) reacting the produced 4- oxodecaline derivative with methyl lithium to afford the compound VI, (5) closing the ring of the compound VI with a mixture of trifluoroacetic acid anhydride and trifluoroacetic acid, (6) brominating the product by conventional method, (7) debrominating the product to afford the compound V, (8) methylating the compound V with lithium dimethl copper, (9) debrominating the product, and (10) again methylating the product with lithium dimethyl copper.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9900178A JPS5527127A (en) | 1978-08-16 | 1978-08-16 | Preparation of 2-oxohibaol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9900178A JPS5527127A (en) | 1978-08-16 | 1978-08-16 | Preparation of 2-oxohibaol |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5527127A true JPS5527127A (en) | 1980-02-27 |
Family
ID=14234737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9900178A Pending JPS5527127A (en) | 1978-08-16 | 1978-08-16 | Preparation of 2-oxohibaol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5527127A (en) |
-
1978
- 1978-08-16 JP JP9900178A patent/JPS5527127A/en active Pending
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