JPS55164695A - Novel aminoglycoside and its preparation - Google Patents

Novel aminoglycoside and its preparation

Info

Publication number
JPS55164695A
JPS55164695A JP7184279A JP7184279A JPS55164695A JP S55164695 A JPS55164695 A JP S55164695A JP 7184279 A JP7184279 A JP 7184279A JP 7184279 A JP7184279 A JP 7184279A JP S55164695 A JPS55164695 A JP S55164695A
Authority
JP
Japan
Prior art keywords
glycyl
formula
methyl
positions
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7184279A
Other languages
Japanese (ja)
Other versions
JPS6320838B2 (en
Inventor
Isamu Watanabe
Takashi Yamaguchi
Takeo Ideushi
Kazuhiro Kamiya
Toshito Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP7184279A priority Critical patent/JPS55164695A/en
Publication of JPS55164695A publication Critical patent/JPS55164695A/en
Publication of JPS6320838B2 publication Critical patent/JPS6320838B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A compound of formula I (one of R1 and R2 is H and the other is methyl; R3 is glycyl, alanyl, etc.; excluding the case that R1 is H, R2 is methyl, R3 is glycyl, and the substitution groups at 5- and 4-positions are trans-configuration) and its acid addition salt.
EXAMPLE: 4-N-Glycyl-KA-6606VI of formula II.
USE: Antibacterial agent.
PROCESS: The objective compound can be obtained by (1) acylating KA-6606VI of formula III which is a metabolic produce of, e.g. Saccharopolyspora hirsuta KC6606 strain, with benzyloxycarbonyl chloride, etc., in an aqueous solution in the presence of sodium carbonate under ice cooling, thereby protecting the amino groups at 1-, 2'- and 6'-positions, (2) separating the product and reacting with N-hydroxysuccinimidyl-N-benzyloxycarbonyl glycine, (3) subjecting the reaction product to the catalytic reduction at room temperature, and (4) eliminating the protecting groups.
COPYRIGHT: (C)1980,JPO&Japio
JP7184279A 1979-06-09 1979-06-09 Novel aminoglycoside and its preparation Granted JPS55164695A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7184279A JPS55164695A (en) 1979-06-09 1979-06-09 Novel aminoglycoside and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7184279A JPS55164695A (en) 1979-06-09 1979-06-09 Novel aminoglycoside and its preparation

Publications (2)

Publication Number Publication Date
JPS55164695A true JPS55164695A (en) 1980-12-22
JPS6320838B2 JPS6320838B2 (en) 1988-04-30

Family

ID=13472188

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7184279A Granted JPS55164695A (en) 1979-06-09 1979-06-09 Novel aminoglycoside and its preparation

Country Status (1)

Country Link
JP (1) JPS55164695A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5488245A (en) * 1977-12-21 1979-07-13 Abbott Lab 22deoxyy2**nnacyl and alkylfortimicin a and b
JPS5490150A (en) * 1977-12-21 1979-07-17 Abbott Lab 22deoxyfortimicin a*44nnalkyl and 44nnacyll22deoxyfortimicin b derivatives and their intermediates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5488245A (en) * 1977-12-21 1979-07-13 Abbott Lab 22deoxyy2**nnacyl and alkylfortimicin a and b
JPS5490150A (en) * 1977-12-21 1979-07-17 Abbott Lab 22deoxyfortimicin a*44nnalkyl and 44nnacyll22deoxyfortimicin b derivatives and their intermediates

Also Published As

Publication number Publication date
JPS6320838B2 (en) 1988-04-30

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