JPS55149245A - Preparation of 3-n-substituted carbamoylthiopropionic acid derivative - Google Patents

Preparation of 3-n-substituted carbamoylthiopropionic acid derivative

Info

Publication number
JPS55149245A
JPS55149245A JP5722679A JP5722679A JPS55149245A JP S55149245 A JPS55149245 A JP S55149245A JP 5722679 A JP5722679 A JP 5722679A JP 5722679 A JP5722679 A JP 5722679A JP S55149245 A JPS55149245 A JP S55149245A
Authority
JP
Japan
Prior art keywords
acid derivative
carbamoylthiopropionic
substituted
compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5722679A
Other languages
Japanese (ja)
Inventor
Tomohiko Munakata
Masaki Shiraki
Yukio Abe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP5722679A priority Critical patent/JPS55149245A/en
Publication of JPS55149245A publication Critical patent/JPS55149245A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: To prepare 3-N-substituted carbamoylthiopropionic acid derivative having analgesic, antiphlogistic and immuno-regulating activities, in one step and in high yield, from a low-cost, non-toxic thiocarbamic acid derivative and a propionic acid derivative.
CONSTITUTION: The titled compound IV is prepared by reacting a thiocarbamic acid derivative I (R1, R2 are H, lower alkyl, aralkyl, aryl, or form together with adjacent N atom a heterocyclic ring) with a propionic acid derivative II (R3, R4 are H, lower alkyl, aralkyl or aryl) or III (Y is halogen). The reaction is pref. carried out in an inert solvent, at room temp., or if necessary with heating or cooling, in the presence of a basic catalyst.
USE: The compound IV is also useful as an intermediate of the compound V which is an effective hypotensor.
COPYRIGHT: (C)1980,JPO&Japio
JP5722679A 1979-05-09 1979-05-09 Preparation of 3-n-substituted carbamoylthiopropionic acid derivative Pending JPS55149245A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5722679A JPS55149245A (en) 1979-05-09 1979-05-09 Preparation of 3-n-substituted carbamoylthiopropionic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5722679A JPS55149245A (en) 1979-05-09 1979-05-09 Preparation of 3-n-substituted carbamoylthiopropionic acid derivative

Publications (1)

Publication Number Publication Date
JPS55149245A true JPS55149245A (en) 1980-11-20

Family

ID=13049606

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5722679A Pending JPS55149245A (en) 1979-05-09 1979-05-09 Preparation of 3-n-substituted carbamoylthiopropionic acid derivative

Country Status (1)

Country Link
JP (1) JPS55149245A (en)

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