JPS55149245A - Preparation of 3-n-substituted carbamoylthiopropionic acid derivative - Google Patents
Preparation of 3-n-substituted carbamoylthiopropionic acid derivativeInfo
- Publication number
- JPS55149245A JPS55149245A JP5722679A JP5722679A JPS55149245A JP S55149245 A JPS55149245 A JP S55149245A JP 5722679 A JP5722679 A JP 5722679A JP 5722679 A JP5722679 A JP 5722679A JP S55149245 A JPS55149245 A JP S55149245A
- Authority
- JP
- Japan
- Prior art keywords
- acid derivative
- carbamoylthiopropionic
- substituted
- compound
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: To prepare 3-N-substituted carbamoylthiopropionic acid derivative having analgesic, antiphlogistic and immuno-regulating activities, in one step and in high yield, from a low-cost, non-toxic thiocarbamic acid derivative and a propionic acid derivative.
CONSTITUTION: The titled compound IV is prepared by reacting a thiocarbamic acid derivative I (R1, R2 are H, lower alkyl, aralkyl, aryl, or form together with adjacent N atom a heterocyclic ring) with a propionic acid derivative II (R3, R4 are H, lower alkyl, aralkyl or aryl) or III (Y is halogen). The reaction is pref. carried out in an inert solvent, at room temp., or if necessary with heating or cooling, in the presence of a basic catalyst.
USE: The compound IV is also useful as an intermediate of the compound V which is an effective hypotensor.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5722679A JPS55149245A (en) | 1979-05-09 | 1979-05-09 | Preparation of 3-n-substituted carbamoylthiopropionic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5722679A JPS55149245A (en) | 1979-05-09 | 1979-05-09 | Preparation of 3-n-substituted carbamoylthiopropionic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55149245A true JPS55149245A (en) | 1980-11-20 |
Family
ID=13049606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5722679A Pending JPS55149245A (en) | 1979-05-09 | 1979-05-09 | Preparation of 3-n-substituted carbamoylthiopropionic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55149245A (en) |
-
1979
- 1979-05-09 JP JP5722679A patent/JPS55149245A/en active Pending
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