JPS55136234A

JPS55136234A - Hb glycopeptide vaccine

Hb glycopeptide vaccine

Info

Publication number: JPS55136234A
Authority: JP; Japan
Prior art keywords: hbsag; hepatitis; antigenicity; virus; amino acids
Prior art date: 1979-04-11
Legal status : Granted

Application number

JP4405979A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6212239B2 (enrdf_load_stackoverflow

Inventor

Hiroyuki Shiraishi

Riyouichi Shirochi

Nakao Ishida

Satoru Funakoshi

Current Assignee

Mitsubishi Tanabe Pharma Corp

GC Biopharma Corp

Original Assignee

Green Cross Corp Japan

Green Cross Corp Korea

Priority date

1979-04-11

Filing date

1979-04-11

Publication date

1980-10-23

1979-04-11 Application filed by Green Cross Corp Japan, Green Cross Corp Korea filed Critical Green Cross Corp Japan

1979-04-11 Priority to JP4405979A priority Critical patent/JPS55136234A/ja

1980-10-23 Publication of JPS55136234A publication Critical patent/JPS55136234A/ja

1987-03-17 Publication of JPS6212239B2 publication Critical patent/JPS6212239B2/ja

Status Granted legal-status Critical Current

Links

229960005486 vaccine Drugs 0.000 title abstract 3
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title abstract 2
102000002068 Glycopeptides Human genes 0.000 title abstract 2
108010015899 Glycopeptides Proteins 0.000 title abstract 2
241000700721 Hepatitis B virus Species 0.000 abstract 2
235000001014 amino acid Nutrition 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
239000000427 antigen Substances 0.000 abstract 2
102000036639 antigens Human genes 0.000 abstract 2
108091007433 antigens Proteins 0.000 abstract 2
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
235000003704 aspartic acid Nutrition 0.000 abstract 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
230000008033 biological extinction Effects 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
229930182830 galactose Natural products 0.000 abstract 1
208000006454 hepatitis Diseases 0.000 abstract 1
231100000283 hepatitis Toxicity 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
210000002381 plasma Anatomy 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1