JPS5511505A

JPS5511505A - Novel 9,3"-acylleucomycin and its preparation

Novel 9,3"-acylleucomycin and its preparation

Info

Publication number: JPS5511505A
Authority: JP; Japan
Prior art keywords: compound; alkanoyl; formula; antibiotic; iii
Prior art date: 1978-06-07
Legal status : Granted

Application number

JP6913678A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6313999B2 (enExample

Inventor

Hideo Sakakibara

Osamu Okegawa

Toshiyuki Watanabe

Tatsuro Fujiwara

Susumu Watanabe

Satoshi Omura

Tetsuo Matsuda

Current Assignee

Toyo Jozo KK

Original Assignee

Toyo Jozo KK

Priority date

1978-06-07

Filing date

1978-06-07

Publication date

1980-01-26

1978-06-07 Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK

1978-06-07 Priority to JP6913678A priority Critical patent/JPS5511505A/ja

1980-01-26 Publication of JPS5511505A publication Critical patent/JPS5511505A/ja

1988-03-29 Publication of JPS6313999B2 publication Critical patent/JPS6313999B2/ja

Status Granted legal-status Critical Current

Links

OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
125000001589 carboacyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
230000003115 biocidal effect Effects 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
208000035473 Communicable disease Diseases 0.000 abstract 1
101100476962 Drosophila melanogaster Sirup gene Proteins 0.000 abstract 1
IEMDOFXTVAPVLX-YWQHLDGFSA-N Leucomycin A1 Chemical compound CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]2O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@](C)(O)C2)[C@@H](C)O1 IEMDOFXTVAPVLX-YWQHLDGFSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
235000019658 bitter taste Nutrition 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
235000020357 syrup Nutrition 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1