JPS5498800A - Preparation of vincadiformin - Google Patents

Preparation of vincadiformin

Info

Publication number
JPS5498800A
JPS5498800A JP16439678A JP16439678A JPS5498800A JP S5498800 A JPS5498800 A JP S5498800A JP 16439678 A JP16439678 A JP 16439678A JP 16439678 A JP16439678 A JP 16439678A JP S5498800 A JPS5498800 A JP S5498800A
Authority
JP
Japan
Prior art keywords
vincadiformin
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16439678A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6215555B2 (OSRAM
Inventor
Ii Kuene Maatein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Publication of JPS5498800A publication Critical patent/JPS5498800A/ja
Publication of JPS6215555B2 publication Critical patent/JPS6215555B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP16439678A 1977-12-29 1978-12-29 Preparation of vincadiformin Granted JPS5498800A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/865,657 US4154943A (en) 1977-12-29 1977-12-29 Preparation of vincadifformine

Publications (2)

Publication Number Publication Date
JPS5498800A true JPS5498800A (en) 1979-08-03
JPS6215555B2 JPS6215555B2 (OSRAM) 1987-04-08

Family

ID=25345973

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16439678A Granted JPS5498800A (en) 1977-12-29 1978-12-29 Preparation of vincadiformin

Country Status (9)

Country Link
US (1) US4154943A (OSRAM)
JP (1) JPS5498800A (OSRAM)
BE (1) BE873136A (OSRAM)
CA (1) CA1098903A (OSRAM)
ES (1) ES476504A1 (OSRAM)
FR (1) FR2413391A1 (OSRAM)
GB (1) GB2011899B (OSRAM)
HU (1) HU180905B (OSRAM)
IT (1) IT1109011B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283536A (en) * 1977-12-29 1981-08-11 University Of Vermont Preparation of vincadifformine and related derivatives
DE2934342A1 (de) * 1978-08-24 1980-03-13 Martin E Kuehne Verfahren zur herstellung von +vincadifformin und verwandter derivate sowie zwischenverbindungen
US4267330A (en) * 1978-08-24 1981-05-12 Omnium Chimique Societe Anonyme Process for the synthesis of vincadifformine and related derivatives
US4220774A (en) * 1978-10-26 1980-09-02 Omnium Chimique Vincadifformine synthesis process
US4362739A (en) * 1981-05-04 1982-12-07 S.A. Omnichem Pyrrolo(2,3-d)carbazole derivatives, compositions and use
US4428880A (en) 1981-05-04 1984-01-31 S.A. Omnichem Azepino[4,5-d]indole derivatives and preparation thereof
LU85894A1 (fr) * 1985-05-10 1986-12-05 Omnichem Sa Derives de 1,2,3,4,5,6-hexahydro-azepino (4,5-b) indole leur preparation,composes intermediaires,et leur application en therapeutique
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
PE20010635A1 (es) * 1999-10-08 2001-08-15 Smithkline Beecham Corp Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
DK1560584T3 (da) * 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitorer
AU2003298937A1 (en) * 2002-12-06 2004-06-30 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
CA2519429C (en) 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
CA2632476A1 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
NZ702695A (en) 2012-06-19 2015-10-30 Debiopharm Int Sa Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
ES2842443T3 (es) 2016-02-26 2021-07-14 Debiopharm Int Sa Medicamento para el tratamiento de infecciones del pie diabético
CN107216328A (zh) * 2017-07-06 2017-09-29 贵州医科大学 一种α‑卡波林类化合物的合成方法
IL285204B2 (en) 2019-02-14 2025-02-01 Debiopharm Int Sa Formulation of apavicin, method for its preparation
EP3982975A1 (en) 2019-06-14 2022-04-20 Debiopharm International SA Afabicin for use for treating bacterial infections involving biofilm
US12116372B1 (en) 2023-12-14 2024-10-15 William Allen Boulanger Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE811614A (en) 1974-02-27 1974-06-17 (-) Vincadifformine prodn. - by hemisynthesis starting from vindolinine which is obtd. from catharantus roseus

Also Published As

Publication number Publication date
FR2413391B1 (OSRAM) 1983-08-05
ES476504A1 (es) 1979-11-16
IT1109011B (it) 1985-12-16
BE873136A (fr) 1979-06-28
GB2011899B (en) 1982-05-26
GB2011899A (en) 1979-07-18
CA1098903A (en) 1981-04-07
JPS6215555B2 (OSRAM) 1987-04-08
FR2413391A1 (fr) 1979-07-27
US4154943A (en) 1979-05-15
HU180905B (en) 1983-05-30
IT7809692A0 (it) 1978-12-29

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