JPS5492697A - Enzyme inhibiting substance m-96 - Google Patents
Enzyme inhibiting substance m-96Info
- Publication number
- JPS5492697A JPS5492697A JP16055877A JP16055877A JPS5492697A JP S5492697 A JPS5492697 A JP S5492697A JP 16055877 A JP16055877 A JP 16055877A JP 16055877 A JP16055877 A JP 16055877A JP S5492697 A JPS5492697 A JP S5492697A
- Authority
- JP
- Japan
- Prior art keywords
- methanol
- chaetomium
- inhibiting substance
- enzyme inhibiting
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000126 substance Substances 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 9
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241001327431 Arcopilus aureus Species 0.000 abstract 1
- 241000221955 Chaetomium Species 0.000 abstract 1
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 abstract 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 abstract 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000921 elemental analysis Methods 0.000 abstract 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
NEW MATERIAL:A novel enzyme inhibiting substance M-69: dark red powder; acidic substance having pKa of 4.85 in 75% methanol; molecular weight measured by equilibrium vapor pressure method, about 574; elemental analysis, C 66.95%, H 6.50%, N 2.44%, O 23.81%; color reaction, ferric chloride reaction, positive; optical rotation, -0.960 (1% concentration, methanol solution, cell length 10 cm), soluble to methanol, ethanol, acetone, chloroform, ethyl acetate; slightly soluble to benzene, ethyl ether; insoluble to hexane.
USE: The compound inhibits the activity of prolinehydroxylase and suppresses the growth of collagen.
PROCESS: M-96-producing microbials belonging to Chaetomium genus, e.g. Chaetomium aureum IFO 6544, are aerobically clutured, and produced M-96 is separated from the medium.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16055877A JPS5492697A (en) | 1977-12-28 | 1977-12-28 | Enzyme inhibiting substance m-96 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16055877A JPS5492697A (en) | 1977-12-28 | 1977-12-28 | Enzyme inhibiting substance m-96 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5492697A true JPS5492697A (en) | 1979-07-23 |
Family
ID=15717577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16055877A Pending JPS5492697A (en) | 1977-12-28 | 1977-12-28 | Enzyme inhibiting substance m-96 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5492697A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102409001A (en) * | 2011-11-01 | 2012-04-11 | 浙江省农业科学院 | Fungus used for performing biological prevention and control on plant soil-borne diseases |
-
1977
- 1977-12-28 JP JP16055877A patent/JPS5492697A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102409001A (en) * | 2011-11-01 | 2012-04-11 | 浙江省农业科学院 | Fungus used for performing biological prevention and control on plant soil-borne diseases |
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