JPS5490174A - Novel indomethacin derivatives and their preparation - Google Patents
Novel indomethacin derivatives and their preparationInfo
- Publication number
- JPS5490174A JPS5490174A JP15956677A JP15956677A JPS5490174A JP S5490174 A JPS5490174 A JP S5490174A JP 15956677 A JP15956677 A JP 15956677A JP 15956677 A JP15956677 A JP 15956677A JP S5490174 A JPS5490174 A JP S5490174A
- Authority
- JP
- Japan
- Prior art keywords
- indomethacin
- novel
- preparation
- formula
- antiphlogistic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15956677A JPS5490174A (en) | 1977-12-27 | 1977-12-27 | Novel indomethacin derivatives and their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15956677A JPS5490174A (en) | 1977-12-27 | 1977-12-27 | Novel indomethacin derivatives and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5490174A true JPS5490174A (en) | 1979-07-17 |
Family
ID=15696519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15956677A Pending JPS5490174A (en) | 1977-12-27 | 1977-12-27 | Novel indomethacin derivatives and their preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5490174A (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58134077A (ja) * | 1982-02-02 | 1983-08-10 | Ss Pharmaceut Co Ltd | 新規なインド−ル酢酸エステル誘導体及びその製造法 |
US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
US6110955A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Metabolically stabilized oxyalkylene esters and uses thereof |
US6207700B1 (en) | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
US6762182B1 (en) | 1999-01-07 | 2004-07-13 | Vanderbilt University | Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors |
US7736624B2 (en) | 2006-06-19 | 2010-06-15 | Univ Vanderbilt | Methods and compositions for diagnostic and therapeutic targeting of COX-2 |
US8168656B2 (en) | 2004-04-26 | 2012-05-01 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
-
1977
- 1977-12-27 JP JP15956677A patent/JPS5490174A/ja active Pending
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6237623B2 (ja) * | 1982-02-02 | 1987-08-13 | Ss Pharmaceutical Co | |
JPS58134077A (ja) * | 1982-02-02 | 1983-08-10 | Ss Pharmaceut Co Ltd | 新規なインド−ル酢酸エステル誘導体及びその製造法 |
US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
US6110955A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Metabolically stabilized oxyalkylene esters and uses thereof |
US6207700B1 (en) | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
US6399647B2 (en) | 1999-01-07 | 2002-06-04 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
US6762182B1 (en) | 1999-01-07 | 2004-07-13 | Vanderbilt University | Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors |
US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
US8168656B2 (en) | 2004-04-26 | 2012-05-01 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
US7736624B2 (en) | 2006-06-19 | 2010-06-15 | Univ Vanderbilt | Methods and compositions for diagnostic and therapeutic targeting of COX-2 |
US8143302B2 (en) | 2006-06-19 | 2012-03-27 | Vanderbilt University | Methods and compositions for diagnostic and therapeutic targeting of COX-2 |
US8865130B2 (en) | 2006-06-19 | 2014-10-21 | Vanderbilt University | Methods and compositions for diagnostic and therapeutic targeting of COX-2 |
US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
US9895351B2 (en) | 2011-10-17 | 2018-02-20 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
US10398678B2 (en) | 2011-10-17 | 2019-09-03 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
US11738004B2 (en) | 2011-10-17 | 2023-08-29 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
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