JPS5476578A - Novel indomethacin glyceride derivative - Google Patents
Novel indomethacin glyceride derivativeInfo
- Publication number
- JPS5476578A JPS5476578A JP14313277A JP14313277A JPS5476578A JP S5476578 A JPS5476578 A JP S5476578A JP 14313277 A JP14313277 A JP 14313277A JP 14313277 A JP14313277 A JP 14313277A JP S5476578 A JPS5476578 A JP S5476578A
- Authority
- JP
- Japan
- Prior art keywords
- indomethacin
- formula
- acid
- alkanoyl
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:Indomethacin glyceride derivatives of formula I (R1 is alkanoyl; R2 is H, alkanoyl).
EXAMPLE: 1-Indomethacoyl-3-palmitoylgycerol.
USE: Anti-flammatory agent with extremely reduced side effects such as intestinal disorder.
PREPARATION: For example, the reaction of an indomethacin monoglyceride of formula II with a reactive derivative of fatty acid given as formula: R1 OH, or between an indomethacin diglyceride of formula III and a reactive derivative of fatty acid of formula R2'OH (R'2 is alkanoyl) gives an indomethacin glyceride derivative of formula I. The reactive derivative of fatty acid is, e.g., an acid anhydride, halide, ester, for example an acid chloride as the acid halide, p-nitrophenyl ester as the ester and a carboxylic hemiester anhydride as the acid anhydride.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14313277A JPS5476578A (en) | 1977-11-28 | 1977-11-28 | Novel indomethacin glyceride derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14313277A JPS5476578A (en) | 1977-11-28 | 1977-11-28 | Novel indomethacin glyceride derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5476578A true JPS5476578A (en) | 1979-06-19 |
Family
ID=15331651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14313277A Pending JPS5476578A (en) | 1977-11-28 | 1977-11-28 | Novel indomethacin glyceride derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5476578A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58134077A (en) * | 1982-02-02 | 1983-08-10 | Ss Pharmaceut Co Ltd | Novel indoleacetic ester derivative and preparation thereof |
JPS58177966A (en) * | 1982-04-09 | 1983-10-18 | Ss Pharmaceut Co Ltd | Novel indoleacetic ester derivative and its preparation |
-
1977
- 1977-11-28 JP JP14313277A patent/JPS5476578A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58134077A (en) * | 1982-02-02 | 1983-08-10 | Ss Pharmaceut Co Ltd | Novel indoleacetic ester derivative and preparation thereof |
JPS6237623B2 (en) * | 1982-02-02 | 1987-08-13 | Ss Pharmaceutical Co | |
JPS58177966A (en) * | 1982-04-09 | 1983-10-18 | Ss Pharmaceut Co Ltd | Novel indoleacetic ester derivative and its preparation |
JPS6234034B2 (en) * | 1982-04-09 | 1987-07-24 | Ss Pharmaceutical Co |
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