JPS5476578A - Novel indomethacin glyceride derivative - Google Patents

Novel indomethacin glyceride derivative

Info

Publication number
JPS5476578A
JPS5476578A JP14313277A JP14313277A JPS5476578A JP S5476578 A JPS5476578 A JP S5476578A JP 14313277 A JP14313277 A JP 14313277A JP 14313277 A JP14313277 A JP 14313277A JP S5476578 A JPS5476578 A JP S5476578A
Authority
JP
Japan
Prior art keywords
indomethacin
formula
acid
alkanoyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14313277A
Other languages
Japanese (ja)
Inventor
Yoshiro Aso
Toshio Atami
Yoshihiro Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP14313277A priority Critical patent/JPS5476578A/en
Publication of JPS5476578A publication Critical patent/JPS5476578A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:Indomethacin glyceride derivatives of formula I (R1 is alkanoyl; R2 is H, alkanoyl).
EXAMPLE: 1-Indomethacoyl-3-palmitoylgycerol.
USE: Anti-flammatory agent with extremely reduced side effects such as intestinal disorder.
PREPARATION: For example, the reaction of an indomethacin monoglyceride of formula II with a reactive derivative of fatty acid given as formula: R1 OH, or between an indomethacin diglyceride of formula III and a reactive derivative of fatty acid of formula R2'OH (R'2 is alkanoyl) gives an indomethacin glyceride derivative of formula I. The reactive derivative of fatty acid is, e.g., an acid anhydride, halide, ester, for example an acid chloride as the acid halide, p-nitrophenyl ester as the ester and a carboxylic hemiester anhydride as the acid anhydride.
COPYRIGHT: (C)1979,JPO&Japio
JP14313277A 1977-11-28 1977-11-28 Novel indomethacin glyceride derivative Pending JPS5476578A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14313277A JPS5476578A (en) 1977-11-28 1977-11-28 Novel indomethacin glyceride derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14313277A JPS5476578A (en) 1977-11-28 1977-11-28 Novel indomethacin glyceride derivative

Publications (1)

Publication Number Publication Date
JPS5476578A true JPS5476578A (en) 1979-06-19

Family

ID=15331651

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14313277A Pending JPS5476578A (en) 1977-11-28 1977-11-28 Novel indomethacin glyceride derivative

Country Status (1)

Country Link
JP (1) JPS5476578A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134077A (en) * 1982-02-02 1983-08-10 Ss Pharmaceut Co Ltd Novel indoleacetic ester derivative and preparation thereof
JPS58177966A (en) * 1982-04-09 1983-10-18 Ss Pharmaceut Co Ltd Novel indoleacetic ester derivative and its preparation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134077A (en) * 1982-02-02 1983-08-10 Ss Pharmaceut Co Ltd Novel indoleacetic ester derivative and preparation thereof
JPS6237623B2 (en) * 1982-02-02 1987-08-13 Ss Pharmaceutical Co
JPS58177966A (en) * 1982-04-09 1983-10-18 Ss Pharmaceut Co Ltd Novel indoleacetic ester derivative and its preparation
JPS6234034B2 (en) * 1982-04-09 1987-07-24 Ss Pharmaceutical Co

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