JPS5470257A - Preparation of optically active pantolactone - Google Patents

Preparation of optically active pantolactone

Info

Publication number
JPS5470257A
JPS5470257A JP13353677A JP13353677A JPS5470257A JP S5470257 A JPS5470257 A JP S5470257A JP 13353677 A JP13353677 A JP 13353677A JP 13353677 A JP13353677 A JP 13353677A JP S5470257 A JPS5470257 A JP S5470257A
Authority
JP
Japan
Prior art keywords
pantolactone
rhodium complex
optically active
butyrolactone
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13353677A
Other languages
Japanese (ja)
Inventor
Kazuo Achinami
Iwao Oshima
Tetsuo Kogure
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP13353677A priority Critical patent/JPS5470257A/en
Publication of JPS5470257A publication Critical patent/JPS5470257A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Abstract

PURPOSE: To obtain the title substance which is a raw material for calcium pantothenate, by catalytic asymmetric hydrogenation of 4,4-dimethyl-3-oxo-γ-butyrolactone, using a rhodium complex having an N-acylpyrrolidinophosphine as a ligand, as a catalyst.
CONSTITUTION: 4,4-Dimethyl-3-oxo-γ-butyrolactone is dissolved in a solvent, e.g. benzene, ether, etc. and hydrogenated in the presence of 0.01W0.5mol% of a rhodium complex at room temperature or at high temperature and pressure of 20W 60°C and several to scores of atmospheres to shorten the reaction time, thus forming the desired compound. The rhodium complex has an N-acylpyrrolidino phosphine of formula (the star is optically active site; R1, R2, R3, and R4 are alkyl or aromatic groups; R5, R6, and R7 are H, alkyl, or aromatic groups) as a ligand. The resulting pantolactone is recrystallized simply to form D-(-)-pantolactone of optical purity 100%.
COPYRIGHT: (C)1979,JPO&Japio
JP13353677A 1977-11-09 1977-11-09 Preparation of optically active pantolactone Pending JPS5470257A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13353677A JPS5470257A (en) 1977-11-09 1977-11-09 Preparation of optically active pantolactone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13353677A JPS5470257A (en) 1977-11-09 1977-11-09 Preparation of optically active pantolactone

Publications (1)

Publication Number Publication Date
JPS5470257A true JPS5470257A (en) 1979-06-05

Family

ID=15107094

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13353677A Pending JPS5470257A (en) 1977-11-09 1977-11-09 Preparation of optically active pantolactone

Country Status (1)

Country Link
JP (1) JPS5470257A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980059286A (en) * 1996-12-31 1998-10-07 박영구 Method for preparing D-(-)-pantolactone

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980059286A (en) * 1996-12-31 1998-10-07 박영구 Method for preparing D-(-)-pantolactone

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