JPS5455581A - Synthetic method of 5-fluorouracil derivative - Google Patents
Synthetic method of 5-fluorouracil derivativeInfo
- Publication number
- JPS5455581A JPS5455581A JP11855977A JP11855977A JPS5455581A JP S5455581 A JPS5455581 A JP S5455581A JP 11855977 A JP11855977 A JP 11855977A JP 11855977 A JP11855977 A JP 11855977A JP S5455581 A JPS5455581 A JP S5455581A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- dihydrofuran
- tetrahydrofuryl
- conducted
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE: The reaction between 5-fluorouracil and 2, 3-dihydrofuran is conducted in the presence of a tertiary amine and a nonmetal halide to prepare under mild conditions title compound used as a carcinostatic agent or synthetic intermediate.
CONSTITUTION: The reaction between 5-fluorouracil and 2, 3-dihydrofuran is conducted in the presence of a tertiary amine, most preferably pyridine, and a nonmetal halide such as silicon tetrachloride or phosphorus trichloride at 50-100°C under normal pressure to form 5-fluorouracil derivative of the formula (A is H, 2-tetrahydrofuryl), which is further treated with an acid such as hydrochloric or acetic aicd to give N1-(2-tetrahydrofuryl)-5-fluorouracil. This compound is used as low-txicity and orally administered carcinostatic agent
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11855977A JPS5455581A (en) | 1977-10-04 | 1977-10-04 | Synthetic method of 5-fluorouracil derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11855977A JPS5455581A (en) | 1977-10-04 | 1977-10-04 | Synthetic method of 5-fluorouracil derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5455581A true JPS5455581A (en) | 1979-05-02 |
Family
ID=14739579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11855977A Pending JPS5455581A (en) | 1977-10-04 | 1977-10-04 | Synthetic method of 5-fluorouracil derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5455581A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102285972A (en) * | 2011-08-08 | 2011-12-21 | 江苏大学 | Process for preparing tegafur |
-
1977
- 1977-10-04 JP JP11855977A patent/JPS5455581A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102285972A (en) * | 2011-08-08 | 2011-12-21 | 江苏大学 | Process for preparing tegafur |
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