JPS5564576A - Preparation of musimol derivative - Google Patents

Preparation of musimol derivative

Info

Publication number
JPS5564576A
JPS5564576A JP13694678A JP13694678A JPS5564576A JP S5564576 A JPS5564576 A JP S5564576A JP 13694678 A JP13694678 A JP 13694678A JP 13694678 A JP13694678 A JP 13694678A JP S5564576 A JPS5564576 A JP S5564576A
Authority
JP
Japan
Prior art keywords
compound
formula
musimol
derivative
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13694678A
Other languages
Japanese (ja)
Other versions
JPS6159307B2 (en
Inventor
Norio Nakamura
Kazu Tajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP13694678A priority Critical patent/JPS5564576A/en
Publication of JPS5564576A publication Critical patent/JPS5564576A/en
Publication of JPS6159307B2 publication Critical patent/JPS6159307B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PURPOSE: To obtain the title compound useful as a medicine having a psychotropic action in short steps, starting from a readily available 3-hydroxy-5-methylisoxazole.
CONSTITUTION: A compound of formula I: (R is H, aryl, or halogen) is reacted with a compound of the formula R'-X (R' is acyl or benzenesulfonyl group; X is halogen) to give a compound of formula II, Which is brominated with N-bromo- succinimide, etc., to form a compound of formula III. The resulting compound is aminated with conc. aqueous anmonia, and the protecting group R' is eliminated to give a musimol of formula IV and its derivative, which is an antiepileptic or cerebral physiological study reagent. The method requires a readily available raw material, produced in large amounts as a pesticide, short steps, and the amination step at normal temperature and pressure. The intermediate is not necessarily purified.
COPYRIGHT: (C)1980,JPO&Japio
JP13694678A 1978-11-07 1978-11-07 Preparation of musimol derivative Granted JPS5564576A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13694678A JPS5564576A (en) 1978-11-07 1978-11-07 Preparation of musimol derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13694678A JPS5564576A (en) 1978-11-07 1978-11-07 Preparation of musimol derivative

Publications (2)

Publication Number Publication Date
JPS5564576A true JPS5564576A (en) 1980-05-15
JPS6159307B2 JPS6159307B2 (en) 1986-12-16

Family

ID=15187210

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13694678A Granted JPS5564576A (en) 1978-11-07 1978-11-07 Preparation of musimol derivative

Country Status (1)

Country Link
JP (1) JPS5564576A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58194867A (en) * 1982-05-10 1983-11-12 Sankyo Co Ltd Preparation of isoxazole derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58194867A (en) * 1982-05-10 1983-11-12 Sankyo Co Ltd Preparation of isoxazole derivative
JPH0411543B2 (en) * 1982-05-10 1992-02-28

Also Published As

Publication number Publication date
JPS6159307B2 (en) 1986-12-16

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