JPS54135797A - Tetrahydro-beta-carboline derivative - Google Patents
Tetrahydro-beta-carboline derivativeInfo
- Publication number
- JPS54135797A JPS54135797A JP4332978A JP4332978A JPS54135797A JP S54135797 A JPS54135797 A JP S54135797A JP 4332978 A JP4332978 A JP 4332978A JP 4332978 A JP4332978 A JP 4332978A JP S54135797 A JPS54135797 A JP S54135797A
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydro
- methyl
- carboline
- ethyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CFTOTSJVQRFXOF-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Chemical class N1C2=CC=CC=C2C2=C1CNCC2 CFTOTSJVQRFXOF-UHFFFAOYSA-N 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- -1 methanol Chemical compound 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 230000000506 psychotropic effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Optically active or inactive tetrahydro-β-carboline derivative of formula I [R1 is monofunctional substitution group; m is 0, 1, 2; when m is 0, (R1)m- is H, and when m is 2, two R1s may together from a ring; R2 is H, methyl, ethyl; R3 is methyl, ethyl, propyl, butyl; C atom having × mark is asymmetric carbon).
EXAMPLE: d-3-Methoxycarbonylmethyl-9-methyl-1-oxo-1, 2, 3, 4-tetrahydro-β-carboline.
USE: Medicine having antiphlogistic, antithrombotic, analgesic, hypotensive, and psychotropic activities. Intermediate of medicines.
PROCESS: The compound I is prepared by heating an optically active or inactive ester of formula II in an alcohol such as methanol, at 50W110°C for 1W4 hours introducing HCl gas to the reaction mixture.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4332978A JPS54135797A (en) | 1978-04-14 | 1978-04-14 | Tetrahydro-beta-carboline derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4332978A JPS54135797A (en) | 1978-04-14 | 1978-04-14 | Tetrahydro-beta-carboline derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS54135797A true JPS54135797A (en) | 1979-10-22 |
Family
ID=12660780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4332978A Pending JPS54135797A (en) | 1978-04-14 | 1978-04-14 | Tetrahydro-beta-carboline derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54135797A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804377A (en) * | 2012-11-08 | 2014-05-21 | 复旦大学 | Corynantheine compound and preparation method thereof |
-
1978
- 1978-04-14 JP JP4332978A patent/JPS54135797A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804377A (en) * | 2012-11-08 | 2014-05-21 | 复旦大学 | Corynantheine compound and preparation method thereof |
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