JPS54119460A - Imidazole derivative - Google Patents
Imidazole derivativeInfo
- Publication number
- JPS54119460A JPS54119460A JP2709878A JP2709878A JPS54119460A JP S54119460 A JPS54119460 A JP S54119460A JP 2709878 A JP2709878 A JP 2709878A JP 2709878 A JP2709878 A JP 2709878A JP S54119460 A JPS54119460 A JP S54119460A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- imidazole
- solvent
- ethyl urocanate
- vinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HPMLGOFBKNGJAM-ONEGZZNKSA-N ethyl (e)-3-(1h-imidazol-5-yl)prop-2-enoate Chemical compound CCOC(=O)\C=C\C1=CN=CN1 HPMLGOFBKNGJAM-ONEGZZNKSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- -1 1-(3-Aminopropyl)-4-(2-ethoxycarbonylethyl)imidazole Chemical compound 0.000 abstract 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- HPMLGOFBKNGJAM-ARJAWSKDSA-N ethyl (z)-3-(1h-imidazol-5-yl)prop-2-enoate Chemical class CCOC(=O)\C=C/C1=CN=CN1 HPMLGOFBKNGJAM-ARJAWSKDSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002184 metal Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 abstract 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Imidazole derivatives of the formula (R is H, alkyl, aryl, aralkyl, ammonium group or metal atom; m is 0 or 2; n is 1 or 2).
EXAMPLE: 1-(3-Aminopropyl)-4-(2-ethoxycarbonylethyl)imidazole.
USE: Medicines as blood sugar depressant or their intermediates.
PREPARATION: Ethyl urocanate is prepared from urocanic acid. Then the reaction of the ethyl urocanate with acrylonitrile in a solvent of acetic acid is effected to afford a mixture of 1-cyanoethyl-4, and 5-(2-ethoxycarbonyl-Z-vinyl)imidazoles. Both compounds are separated by extracting with an aprotonic solvent as chloroform and the cyano and vinyl groups are hydorogenated to prepare the objective compound of the formula.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2709878A JPS54119460A (en) | 1978-03-09 | 1978-03-09 | Imidazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2709878A JPS54119460A (en) | 1978-03-09 | 1978-03-09 | Imidazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54119460A true JPS54119460A (en) | 1979-09-17 |
Family
ID=12211600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2709878A Pending JPS54119460A (en) | 1978-03-09 | 1978-03-09 | Imidazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54119460A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010126464A (en) * | 2008-11-26 | 2010-06-10 | Asahi Kasei E-Materials Corp | Method for producing amino group-containing imidazoles |
-
1978
- 1978-03-09 JP JP2709878A patent/JPS54119460A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010126464A (en) * | 2008-11-26 | 2010-06-10 | Asahi Kasei E-Materials Corp | Method for producing amino group-containing imidazoles |
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