JPS54112896A - Preparation of maytansines - Google Patents
Preparation of maytansinesInfo
- Publication number
- JPS54112896A JPS54112896A JP1867578A JP1867578A JPS54112896A JP S54112896 A JPS54112896 A JP S54112896A JP 1867578 A JP1867578 A JP 1867578A JP 1867578 A JP1867578 A JP 1867578A JP S54112896 A JPS54112896 A JP S54112896A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- maytansinol
- maytansine
- prepared
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 abstract 2
- 229930126263 Maytansine Natural products 0.000 abstract 2
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- WKPWGQKGSOKKOO-RSFHAFMBSA-N maytansine Chemical compound CO[C@@H]([C@@]1(O)C[C@](OC(=O)N1)([C@H]([C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N1C)C)[H])\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 WKPWGQKGSOKKOO-RSFHAFMBSA-N 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- VPKDCDLSJZCGKE-UHFFFAOYSA-N methanediimine Chemical compound N=C=N VPKDCDLSJZCGKE-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1867578A JPS54112896A (en) | 1978-02-20 | 1978-02-20 | Preparation of maytansines |
| US05/886,815 US4137230A (en) | 1977-11-14 | 1978-03-15 | Method for the production of maytansinoids |
| US05/948,895 US4190580A (en) | 1977-11-14 | 1978-10-05 | Optically active maytansinoids and maytansinoid production method |
| CA316,118A CA1097627A (en) | 1977-11-14 | 1978-11-10 | Method for the production of maytansinoids |
| CH1160678A CH637398A5 (de) | 1977-11-14 | 1978-11-10 | Verfahren zur herstellung von maytansinoidverbindungen. |
| DE19782849090 DE2849090A1 (de) | 1977-11-14 | 1978-11-11 | Verfahren zur herstellung von maytansinoidverbindungen |
| SE7811689A SE441830B (sv) | 1977-11-14 | 1978-11-13 | Forfarande for framstellning av maytansinoider |
| FR7832040A FR2416895A1 (fr) | 1977-11-14 | 1978-11-13 | Procede de production de maytansinoides |
| DK503978A DK503978A (da) | 1977-11-14 | 1978-11-13 | Fremgangsmaade til fremstilling af maytansinoider |
| IT29728/78A IT1100898B (it) | 1977-11-14 | 1978-11-13 | Procedimento per produrre composti maitansinoidi |
| GB7844415A GB2009742B (en) | 1977-11-14 | 1978-11-14 | Process for the preparation of maytansinoids and d-maytansinoids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1867578A JPS54112896A (en) | 1978-02-20 | 1978-02-20 | Preparation of maytansines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54112896A true JPS54112896A (en) | 1979-09-04 |
| JPS6152835B2 JPS6152835B2 (enrdf_load_stackoverflow) | 1986-11-14 |
Family
ID=11978169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1867578A Granted JPS54112896A (en) | 1977-11-14 | 1978-02-20 | Preparation of maytansines |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54112896A (enrdf_load_stackoverflow) |
-
1978
- 1978-02-20 JP JP1867578A patent/JPS54112896A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6152835B2 (enrdf_load_stackoverflow) | 1986-11-14 |
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