JPS54112863A - N-(omega-carboxyalkyl)imidazole - Google Patents
N-(omega-carboxyalkyl)imidazoleInfo
- Publication number
- JPS54112863A JPS54112863A JP1834078A JP1834078A JPS54112863A JP S54112863 A JPS54112863 A JP S54112863A JP 1834078 A JP1834078 A JP 1834078A JP 1834078 A JP1834078 A JP 1834078A JP S54112863 A JPS54112863 A JP S54112863A
- Authority
- JP
- Japan
- Prior art keywords
- imidazole
- compound
- thromboxane
- base
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 10
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- HAEKKZYPJPHQOP-UHFFFAOYSA-N 5-imidazol-1-ylpentanoic acid;hydrochloride Chemical compound Cl.OC(=O)CCCCN1C=CN=C1 HAEKKZYPJPHQOP-UHFFFAOYSA-N 0.000 abstract 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 206010020852 Hypertonia Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052987 metal hydride Inorganic materials 0.000 abstract 1
- 150000004681 metal hydrides Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- -1 phlegmasia Chemical compound 0.000 abstract 1
- 125000000542 sulfonic acid group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53018340A JPS601313B2 (ja) | 1978-02-20 | 1978-02-20 | Ｎ↓−（ω↓−カルボキシアルキル）イミダゾール |
| GB7904557A GB2016452B (en) | 1978-02-18 | 1979-02-08 | Imidazole compounds |
| CA321,246A CA1123841A (en) | 1978-02-18 | 1979-02-12 | Process for the production of novel imidazole compounds |
| DE19792905811 DE2905811A1 (de) | 1978-02-18 | 1979-02-15 | Imidazol-verbindungen |
| FR7904020A FR2417504A1 (fr) | 1978-02-18 | 1979-02-16 | Composes d'imidazole |
| IT48031/79A IT1162269B (it) | 1978-02-18 | 1979-02-16 | Composti di imidazolo e procedimento per applicarli |
| US06/014,001 US4320134A (en) | 1978-02-18 | 1979-02-21 | Inhibiton of thromboxane synthetase with 1-substituted imidazole compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53018340A JPS601313B2 (ja) | 1978-02-20 | 1978-02-20 | Ｎ↓−（ω↓−カルボキシアルキル）イミダゾール |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54112863A true JPS54112863A (en) | 1979-09-04 |
| JPS601313B2 JPS601313B2 (ja) | 1985-01-14 |
Family
ID=11968912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53018340A Expired JPS601313B2 (ja) | 1978-02-18 | 1978-02-20 | Ｎ↓−（ω↓−カルボキシアルキル）イミダゾール |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS601313B2 (ja) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5756464A (en) * | 1980-09-22 | 1982-04-05 | Ono Pharmaceut Co Ltd | Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 |
-
1978
- 1978-02-20 JP JP53018340A patent/JPS601313B2/ja not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5756464A (en) * | 1980-09-22 | 1982-04-05 | Ono Pharmaceut Co Ltd | Imidazole derivative ahd inhibitor for biosyntesis of thromboxane a2 |
| JPS622586B2 (ja) * | 1980-09-22 | 1987-01-20 | Ono Yakuhin Kogyo Kk |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS601313B2 (ja) | 1985-01-14 |
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