JPS54106472A - Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione - Google Patents

Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione

Info

Publication number
JPS54106472A
JPS54106472A JP1147278A JP1147278A JPS54106472A JP S54106472 A JPS54106472 A JP S54106472A JP 1147278 A JP1147278 A JP 1147278A JP 1147278 A JP1147278 A JP 1147278A JP S54106472 A JPS54106472 A JP S54106472A
Authority
JP
Japan
Prior art keywords
formula
acidic substance
compound
thiourea
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1147278A
Other languages
Japanese (ja)
Inventor
Tetsuro Shibahara
Masaaki Furuya
Shinzo Imamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP1147278A priority Critical patent/JPS54106472A/en
Publication of JPS54106472A publication Critical patent/JPS54106472A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound which is an intermediate for medicines in simple procedures in high yield, by treating a specific compound, readily prepared through addition reaction between 2-amino-cyclohexanone oxime and a thioisocyanate, with an acidic substance.
CONSTITUTION: A N-(2-hydroxyimino-cyclohexyl)-thiourea of formula I: (R is alkyl, allyl, or aralkyl group) is brought into contact with an acidic substance, e.g. hydrogen chloride, hydrogen bromide, sulfuric or benzenesulfonic acid, at 0W 150°C, preferably 10W100°C to give the objective compound of formula II. The thiourea of formula I is obtained by addition reaction of 2-amino-cyclohexanone oxime with a thiocyanate of formula IV according to the well-known method. Preferably, the amount of the acidic substance is 0.01 mole or more per mole of the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP1147278A 1978-02-06 1978-02-06 Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione Pending JPS54106472A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1147278A JPS54106472A (en) 1978-02-06 1978-02-06 Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1147278A JPS54106472A (en) 1978-02-06 1978-02-06 Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione

Publications (1)

Publication Number Publication Date
JPS54106472A true JPS54106472A (en) 1979-08-21

Family

ID=11779005

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1147278A Pending JPS54106472A (en) 1978-02-06 1978-02-06 Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione

Country Status (1)

Country Link
JP (1) JPS54106472A (en)

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