JPS54106472A - Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione - Google Patents
Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thioneInfo
- Publication number
- JPS54106472A JPS54106472A JP1147278A JP1147278A JPS54106472A JP S54106472 A JPS54106472 A JP S54106472A JP 1147278 A JP1147278 A JP 1147278A JP 1147278 A JP1147278 A JP 1147278A JP S54106472 A JPS54106472 A JP S54106472A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- acidic substance
- compound
- thiourea
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound which is an intermediate for medicines in simple procedures in high yield, by treating a specific compound, readily prepared through addition reaction between 2-amino-cyclohexanone oxime and a thioisocyanate, with an acidic substance.
CONSTITUTION: A N-(2-hydroxyimino-cyclohexyl)-thiourea of formula I: (R is alkyl, allyl, or aralkyl group) is brought into contact with an acidic substance, e.g. hydrogen chloride, hydrogen bromide, sulfuric or benzenesulfonic acid, at 0W 150°C, preferably 10W100°C to give the objective compound of formula II. The thiourea of formula I is obtained by addition reaction of 2-amino-cyclohexanone oxime with a thiocyanate of formula IV according to the well-known method. Preferably, the amount of the acidic substance is 0.01 mole or more per mole of the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1147278A JPS54106472A (en) | 1978-02-06 | 1978-02-06 | Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1147278A JPS54106472A (en) | 1978-02-06 | 1978-02-06 | Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54106472A true JPS54106472A (en) | 1979-08-21 |
Family
ID=11779005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1147278A Pending JPS54106472A (en) | 1978-02-06 | 1978-02-06 | Preparation of 4, 5, 6, 7-tetrahydro-benzimidazoline-2-thione |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54106472A (en) |
-
1978
- 1978-02-06 JP JP1147278A patent/JPS54106472A/en active Pending
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