JPS53103478A - Method of producing erythro alphaa22piperidyl 2*88bis*trifluoromethyl**44quinolinemethanol - Google Patents
Method of producing erythro alphaa22piperidyl 2*88bis*trifluoromethyl**44quinolinemethanolInfo
- Publication number
- JPS53103478A JPS53103478A JP1601378A JP1601378A JPS53103478A JP S53103478 A JPS53103478 A JP S53103478A JP 1601378 A JP1601378 A JP 1601378A JP 1601378 A JP1601378 A JP 1601378A JP S53103478 A JPS53103478 A JP S53103478A
- Authority
- JP
- Japan
- Prior art keywords
- 88bis
- trifluoromethyl
- erythro
- producing
- producing erythro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76981677A | 1977-02-17 | 1977-02-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS53103478A true JPS53103478A (en) | 1978-09-08 |
| JPS6257631B2 JPS6257631B2 (nl) | 1987-12-02 |
Family
ID=25086585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1601378A Granted JPS53103478A (en) | 1977-02-17 | 1978-02-16 | Method of producing erythro alphaa22piperidyl 2*88bis*trifluoromethyl**44quinolinemethanol |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS53103478A (nl) |
| AT (1) | AT358044B (nl) |
| BE (1) | BE864002A (nl) |
| CH (2) | CH640530A5 (nl) |
| DE (1) | DE2806909A1 (nl) |
| FR (1) | FR2381044A1 (nl) |
| GB (1) | GB1594282A (nl) |
| IT (1) | IT1158450B (nl) |
| NL (1) | NL7801787A (nl) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58188878A (ja) * | 1982-04-14 | 1983-11-04 | エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト | メフロキンの精製方法 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2940443A1 (de) * | 1979-10-05 | 1981-04-16 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von erythro-(alpha)-2-piperidyl-2,8-bis-(trifluormethyl)-4-chinolin-methanol |
| FR2485014A1 (fr) * | 1980-06-20 | 1981-12-24 | Pharmindustrie | Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments |
| DK160499C (da) * | 1982-09-10 | 1991-08-26 | Hoffmann La Roche | Fremgangsmaade til fremstilling af mefloquin og mellemprodukt til anvendelse herved |
| JPH0234129U (nl) * | 1989-05-25 | 1990-03-05 | ||
| HUT54363A (en) * | 1989-07-25 | 1991-02-28 | Alkaloida Vegyeszeti Gyar | Process for producing pyridyl-methyl-quinolin derivatives |
| GB9819382D0 (en) * | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds I |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH590274A5 (nl) * | 1970-03-16 | 1977-07-29 | Hoffmann La Roche | |
| CH605916A5 (nl) * | 1973-12-07 | 1978-10-13 | Hoffmann La Roche |
-
1978
- 1978-02-15 FR FR7804271A patent/FR2381044A1/fr active Granted
- 1978-02-16 AT AT113378A patent/AT358044B/de not_active IP Right Cessation
- 1978-02-16 CH CH169578A patent/CH640530A5/de not_active IP Right Cessation
- 1978-02-16 IT IT20331/78A patent/IT1158450B/it active
- 1978-02-16 BE BE185206A patent/BE864002A/xx not_active IP Right Cessation
- 1978-02-16 NL NL7801787A patent/NL7801787A/nl not_active Application Discontinuation
- 1978-02-16 JP JP1601378A patent/JPS53103478A/ja active Granted
- 1978-02-16 GB GB6207/78A patent/GB1594282A/en not_active Expired
- 1978-02-17 DE DE19782806909 patent/DE2806909A1/de active Granted
-
1982
- 1982-05-14 CH CH301282A patent/CH640531A5/de not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58188878A (ja) * | 1982-04-14 | 1983-11-04 | エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト | メフロキンの精製方法 |
| JPH0127070B2 (nl) * | 1982-04-14 | 1989-05-26 | Efu Hofuman Ra Roshu Unto Co Ag |
Also Published As
| Publication number | Publication date |
|---|---|
| CH640530A5 (en) | 1984-01-13 |
| CH640531A5 (en) | 1984-01-13 |
| ATA113378A (de) | 1980-01-15 |
| JPS6257631B2 (nl) | 1987-12-02 |
| FR2381044A1 (fr) | 1978-09-15 |
| DE2806909C2 (nl) | 1988-04-07 |
| AT358044B (de) | 1980-08-11 |
| IT7820331A0 (it) | 1978-02-16 |
| DE2806909A1 (de) | 1978-08-24 |
| GB1594282A (en) | 1981-07-30 |
| BE864002A (fr) | 1978-08-16 |
| IT1158450B (it) | 1987-02-18 |
| FR2381044B1 (nl) | 1983-06-10 |
| NL7801787A (nl) | 1978-08-21 |
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