JPS5152176A - - Google Patents
Info
- Publication number
- JPS5152176A JPS5152176A JP49117503A JP11750374A JPS5152176A JP S5152176 A JPS5152176 A JP S5152176A JP 49117503 A JP49117503 A JP 49117503A JP 11750374 A JP11750374 A JP 11750374A JP S5152176 A JPS5152176 A JP S5152176A
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP49117503A JPS5152176A (de) | 1974-10-12 | 1974-10-12 | |
| BE160739A BE834247A (fr) | 1974-10-12 | 1975-10-06 | Nouveaux composes chimiques utiles en therapeutique humaine |
| NL7511857A NL7511857A (nl) | 1974-10-12 | 1975-10-09 | Werkwijze voor het bereiden van derivaten van ure- um of thioureum, werkwijze voor het bereiden van een geneesmiddel, die deze verbinding bevat en het volgens deze werkwijze verkregen geneesmiddel. |
| AU85643/75A AU8564375A (en) | 1974-10-12 | 1975-10-10 | Urea or thiourea derivatives |
| DE19752545501 DE2545501A1 (de) | 1974-10-12 | 1975-10-10 | 4-piperidylharnstoff- und thioharnstoff-derivate |
| SE7511408A SE7511408L (sv) | 1974-10-12 | 1975-10-10 | Forfarnde for framstellning av karbamid- eller tiokarbamidderivat |
| FR7531221A FR2287228A1 (fr) | 1974-10-12 | 1975-10-13 | Nouveaux composes chimiques utiles en therapeutique humaine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP49117503A JPS5152176A (de) | 1974-10-12 | 1974-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5152176A true JPS5152176A (de) | 1976-05-08 |
Family
ID=14713345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP49117503A Pending JPS5152176A (de) | 1974-10-12 | 1974-10-12 |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5152176A (de) |
| AU (1) | AU8564375A (de) |
| BE (1) | BE834247A (de) |
| DE (1) | DE2545501A1 (de) |
| FR (1) | FR2287228A1 (de) |
| NL (1) | NL7511857A (de) |
| SE (1) | SE7511408L (de) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01316356A (ja) * | 1987-11-27 | 1989-12-21 | Eisai Co Ltd | 環状アミン誘導体 |
| US7393861B2 (en) * | 1999-12-14 | 2008-07-01 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 4-aminopiperidine and their use as a medicament |
| US7601740B2 (en) | 2003-01-16 | 2009-10-13 | Acadia Pharmaceuticals, Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US7820695B2 (en) | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US7863296B2 (en) | 2004-05-21 | 2011-01-04 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US9050343B2 (en) | 2007-03-19 | 2015-06-09 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and risperidone for the treatment of psychosis |
| US10449185B2 (en) | 2017-08-30 | 2019-10-22 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
| US10517860B2 (en) | 2016-03-25 | 2019-12-31 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| US10981870B2 (en) | 2015-07-20 | 2021-04-20 | Acadia Pharmaceuticals Inc. | Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form |
| US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| US11464768B2 (en) | 2016-12-20 | 2022-10-11 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4203988A (en) | 1975-11-12 | 1980-05-20 | Merck & Co., Inc. | Pyridinyl ureas and pharmaceutical use |
| GB1561023A (en) * | 1977-04-22 | 1980-02-13 | Beecham Group Ltd | 2-methoxy - 5 - chloro aniline derivatives |
| US4806552A (en) * | 1980-03-01 | 1989-02-21 | John Wyeth & Brother, Limited | Pyridyl- and/or pyridoyl-(piperid-4-yl) ureas and analogues thereof |
| CA1173037A (en) | 1980-03-01 | 1984-08-21 | John L. Archibald | Piperidino ureas as antidepressants |
| US4722930A (en) * | 1980-03-01 | 1988-02-02 | John Wyeth And Brother Limited | 3-benzoyl-1-[(oxo or thioheteroaryl-ylalkyl)-piperid-4-yl]ureas and derivatives |
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| AUPP818099A0 (en) * | 1999-01-14 | 1999-02-11 | Fujisawa Pharmaceutical Co., Ltd. | New n-containing heterocyclic compounds |
| WO2001068604A2 (en) * | 2000-03-14 | 2001-09-20 | Sepracor, Inc. | 3-substituted piperidines comprising urea functionality, and methods of use thereof |
| WO2024067304A1 (zh) * | 2022-09-28 | 2024-04-04 | 瀚远医药有限公司 | 一种具有Sigma2和5HT2A抑制活性的化合物及用途 |
-
1974
- 1974-10-12 JP JP49117503A patent/JPS5152176A/ja active Pending
-
1975
- 1975-10-06 BE BE160739A patent/BE834247A/xx unknown
- 1975-10-09 NL NL7511857A patent/NL7511857A/xx unknown
- 1975-10-10 SE SE7511408A patent/SE7511408L/xx unknown
- 1975-10-10 DE DE19752545501 patent/DE2545501A1/de active Pending
- 1975-10-10 AU AU85643/75A patent/AU8564375A/en not_active Expired
- 1975-10-13 FR FR7531221A patent/FR2287228A1/fr not_active Withdrawn
Cited By (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01316356A (ja) * | 1987-11-27 | 1989-12-21 | Eisai Co Ltd | 環状アミン誘導体 |
| US8110574B2 (en) | 1999-12-14 | 2012-02-07 | Ipsen Pharma S.A.S. | Derivatives of 4-aminopiperidine and their use as a medicament |
| US7393861B2 (en) * | 1999-12-14 | 2008-07-01 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 4-aminopiperidine and their use as a medicament |
| US9566271B2 (en) | 2003-01-16 | 2017-02-14 | Acadia Pharmaceuticals Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US8618130B2 (en) | 2003-01-16 | 2013-12-31 | Acadia Pharmaceuticals Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US10028944B2 (en) | 2003-01-16 | 2018-07-24 | Acadia Pharmaceuticals Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US7994193B2 (en) | 2003-01-16 | 2011-08-09 | Acadia Pharmaceuticals Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US8008323B2 (en) | 2003-01-16 | 2011-08-30 | Acadia Pharmaceuticals Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US7601740B2 (en) | 2003-01-16 | 2009-10-13 | Acadia Pharmaceuticals, Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US8377959B2 (en) | 2003-01-16 | 2013-02-19 | Acadia Pharmaceuticals, Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US10525046B2 (en) | 2003-01-16 | 2020-01-07 | Acadia Pharmaceuticals Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US8921393B2 (en) | 2003-01-16 | 2014-12-30 | Acadia Pharmaceuticals Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US9211289B2 (en) | 2003-01-16 | 2015-12-15 | Acadia Pharmaceuticals Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US7820695B2 (en) | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US7875632B2 (en) | 2004-05-21 | 2011-01-25 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US7863296B2 (en) | 2004-05-21 | 2011-01-04 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US9050343B2 (en) | 2007-03-19 | 2015-06-09 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and risperidone for the treatment of psychosis |
| US10981870B2 (en) | 2015-07-20 | 2021-04-20 | Acadia Pharmaceuticals Inc. | Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form |
| US10981871B2 (en) | 2015-07-20 | 2021-04-20 | Acadia Pharmaceuticals Inc. | Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form C |
| US11840515B2 (en) | 2015-07-20 | 2023-12-12 | Acadia Pharmaceuticals Inc. | Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c |
| US10517860B2 (en) | 2016-03-25 | 2019-12-31 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| US11191757B2 (en) | 2016-03-25 | 2021-12-07 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| US11464768B2 (en) | 2016-12-20 | 2022-10-11 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis |
| US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| US10646480B2 (en) | 2017-08-30 | 2020-05-12 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
| US10849891B2 (en) | 2017-08-30 | 2020-12-01 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
| US10449185B2 (en) | 2017-08-30 | 2019-10-22 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
| US11452721B2 (en) | 2017-08-30 | 2022-09-27 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
Also Published As
| Publication number | Publication date |
|---|---|
| AU8564375A (en) | 1977-04-21 |
| SE7511408L (sv) | 1976-04-13 |
| BE834247A (fr) | 1976-02-02 |
| FR2287228A1 (fr) | 1976-05-07 |
| NL7511857A (nl) | 1976-04-14 |
| DE2545501A1 (de) | 1976-04-22 |