JPS51144719A - Preparation of crystalline frunisolide and ittcontaining composition - Google Patents

Preparation of crystalline frunisolide and ittcontaining composition

Info

Publication number
JPS51144719A
JPS51144719A JP51061032A JP6103276A JPS51144719A JP S51144719 A JPS51144719 A JP S51144719A JP 51061032 A JP51061032 A JP 51061032A JP 6103276 A JP6103276 A JP 6103276A JP S51144719 A JPS51144719 A JP S51144719A
Authority
JP
Japan
Prior art keywords
ittcontaining
frunisolide
crystalline
preparation
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP51061032A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6247880B2 (enrdf_load_stackoverflow
Inventor
Eichi Furiido Jiyon
Ii Jiyoonzu Richiyaado
Tei Haringaa Gisera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of JPS51144719A publication Critical patent/JPS51144719A/ja
Publication of JPS6247880B2 publication Critical patent/JPS6247880B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
JP51061032A 1975-05-27 1976-05-26 Preparation of crystalline frunisolide and ittcontaining composition Granted JPS51144719A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130075A 1975-05-27 1975-05-27
US58130175A 1975-05-27 1975-05-27

Publications (2)

Publication Number Publication Date
JPS51144719A true JPS51144719A (en) 1976-12-13
JPS6247880B2 JPS6247880B2 (enrdf_load_stackoverflow) 1987-10-09

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51061032A Granted JPS51144719A (en) 1975-05-27 1976-05-26 Preparation of crystalline frunisolide and ittcontaining composition

Country Status (15)

Country Link
JP (1) JPS51144719A (enrdf_load_stackoverflow)
AT (1) AT357702B (enrdf_load_stackoverflow)
AU (1) AU506080B2 (enrdf_load_stackoverflow)
CA (1) CA1075228A (enrdf_load_stackoverflow)
DE (2) DE2661037C2 (enrdf_load_stackoverflow)
ES (1) ES448220A1 (enrdf_load_stackoverflow)
FR (1) FR2361900A1 (enrdf_load_stackoverflow)
GB (1) GB1525181A (enrdf_load_stackoverflow)
HK (1) HK8580A (enrdf_load_stackoverflow)
IL (1) IL49652A (enrdf_load_stackoverflow)
MX (1) MX3864E (enrdf_load_stackoverflow)
MY (1) MY8000275A (enrdf_load_stackoverflow)
NL (1) NL191234C (enrdf_load_stackoverflow)
NZ (1) NZ180946A (enrdf_load_stackoverflow)
SE (1) SE421426B (enrdf_load_stackoverflow)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004339213A (ja) * 2003-04-25 2004-12-02 Rohto Pharmaceut Co Ltd 点鼻剤
JP2010280722A (ja) * 2003-04-25 2010-12-16 Rohto Pharmaceut Co Ltd 点鼻剤
JP2016515525A (ja) * 2013-03-15 2016-05-30 メディシス ファーマシューティカル コーポレイション フルニソリドの局所用組成物および治療方法

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE883381A (fr) * 1979-05-21 1980-11-20 Syntex Corp Procede de preparation d'une modification cristalline de flunisolide
EP0039369B1 (en) * 1980-05-02 1983-06-15 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
KR0132576B1 (ko) * 1988-10-05 1998-04-17 로렌스 티. 웰츠 항-용매 내로의 침전을 통한 미분 고형물 결정 분말의 제조 방법
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
EE03509B2 (et) * 1995-06-27 2015-02-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Stabiilsed ravimikompositsioonid kandegaasita aerosoolide saamiseks
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
ATE487506T1 (de) * 1999-03-03 2010-11-15 Optinose As Nasales verabreichungsgerät
IT1313553B1 (it) * 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
JP5392880B2 (ja) 2000-05-22 2014-01-22 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 加圧式定量吸入器のための安定な製薬学的溶液製剤
DE60103527T2 (de) 2001-07-02 2005-06-16 Chiesi Farmaceutici S.P.A. Optimierte Tobramycin-Formulierung zur Aerosolbildung
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) 1964-03-24 Chioacyl
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
DE2015300A1 (de) * 1969-04-01 1970-10-29 Syntex Corp., Panania;PM örtliche, entzündungshemmende Präparate und Verfahren zu ihrer Verwendung
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (de) * 1973-06-23 1986-07-31 Schering AG, 1000 Berlin und 4709 Bergkamen Verwendung von Kortikoid-Wirkstoffen zur Inhalationstherapie
US3934013A (en) 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004339213A (ja) * 2003-04-25 2004-12-02 Rohto Pharmaceut Co Ltd 点鼻剤
JP2010280722A (ja) * 2003-04-25 2010-12-16 Rohto Pharmaceut Co Ltd 点鼻剤
JP2016515525A (ja) * 2013-03-15 2016-05-30 メディシス ファーマシューティカル コーポレイション フルニソリドの局所用組成物および治療方法

Also Published As

Publication number Publication date
DE2624924C2 (de) 1986-11-27
AU1430176A (en) 1977-12-01
IL49652A (en) 1979-05-31
MX3864E (es) 1981-08-26
DE2624924A1 (de) 1977-12-15
MY8000275A (en) 1980-12-31
ATA388376A (de) 1979-12-15
SE421426B (sv) 1981-12-21
GB1525181A (en) 1978-09-20
JPS6247880B2 (enrdf_load_stackoverflow) 1987-10-09
ES448220A1 (es) 1977-11-01
FR2361900B1 (enrdf_load_stackoverflow) 1979-04-13
SE7605927L (sv) 1976-11-28
IL49652A0 (en) 1976-07-30
FR2361900A1 (fr) 1978-03-17
NL191234C (nl) 1995-04-03
NL191234B (nl) 1994-11-01
NL7605699A (nl) 1976-11-30
CA1075228A (en) 1980-04-08
AU506080B2 (en) 1979-12-13
HK8580A (en) 1980-03-14
DE2661037C2 (enrdf_load_stackoverflow) 1989-04-06
AT357702B (de) 1980-07-25
NZ180946A (en) 1978-07-28

Similar Documents

Publication Publication Date Title
JPS51144719A (en) Preparation of crystalline frunisolide and ittcontaining composition
JPS51146449A (en) Preparation of novel cromanci compound and pharmaceutical composition
IL50103A (en) 3-oximes of d-17a-ethynyl-19-nortestosterone esters,their preparation and compositions containing them
JPS51136772A (en) Preparation of high ciss1*44polybutadiene
JPS51138626A (en) Novel compound and preparation thereof
JPS5251330A (en) Preparation of trichloromethyll trifluoromethyllbenzene
JPS51131836A (en) Preparation of acetoacetylarylamide
JPS51115427A (en) Preparation of ethylbenzole
JPS5253857A (en) Novel oxazolidinee22one compound and preparation thereof
JPS51143627A (en) Preparation of 2* 55dichlorotoluene
JPS51144720A (en) Stable medical composition and its preparation of ergotalkaloids
JPS5259118A (en) Preparation of trichloromethyll trifluoromethyllbenzene
IL49686A0 (en) Preparation of 3-phenoxybenzaldehydes
GB1531301A (en) N-aralkyl-2-amino-propanamides methods for their preparation and compositions containing them
JPS5217454A (en) Preparation and use of novel 22hydroxynaphthalinee 11aldehyde
JPS5259119A (en) Preparation of trichloromethyll trifluoromethyllbenzene
IL50634A0 (en) Preparation of 2-amino-1-alcohols
JPS5273832A (en) Preparation of halogennitrobenzole
JPS55149273A (en) Novel 33furyllbetaachalcogennalkylsulfide* its manufacture and composition using same
IL50150A0 (en) Preparation of 3-methoxymethyl-cephalosporins
NZ181026A (en) Preparation of n-oxazol-2-ylcarboxamides
JPS5223028A (en) Preparation of alpha* alpha* alpha** alpha** alphaapentachlorooooxylol
GB1546569A (en) 1-oxa-1-dethiapenicillins methods for their preparation and compositions containing them
JPS5219690A (en) Production and composition of morphantlysine derivatives
JPS51135228A (en) Preparation of leaffmold